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ALX-105-001
Revised 06-Jun-06
NG-Nitro-L-arginine
SYNONYMS
L-NOARG
L-Nitroarginine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers:
Format:
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ALX-105-001-G005
5 g
22.00 USD
ALX-105-001-G025
25 g
63.00 USD
Product Specification
FORMULA:
C
6
H
13
N
5
O
4
MW:
219.2
CAS NUMBER:
2149-70-4
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 0.1N HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibitor of nitric oxide synthase (NOS).
Product Specific Literature References
L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle
:
A. Gibson, et al.; Br. J. Pharmacol.
99
, 602 (1990)
Abstract
N omega-nitro-L-arginine: a potent inhibitor of endothelium-derived relaxing factor formation:
K. Ishii, et al.; Eur. J. Pharmacol.
176
, 219 (1990)
Abstract
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro:
P.K. Moore, et al.; Br. J. Pharmacol.
99
, 408 (1990)
Abstract
Inhibitory effects of L-NG-nitro-arginine on the synthesis of EDRF and the cerebroarterial response to vasodilator nerve stimulation:
N. Toda, et al.; Life. Sci.
47
, 345 (1990)
Abstract
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle:
S.R. Brave, et al.; BBRC
179
, 1017 (1991)
Abstract
Nitric oxide synthase: irreversible inhibition by L-NG-nitroarginine in brain in vitro and in vivo:
M.A. Dwyer, et al.; BBRC
176
, 1136 (1991)
Abstract
On the substrate specificity of nitric oxide synthase:
M. Hecker, et al.; FEBS Lett.
294
, 221 (1991)
Abstract
Enhanced photorelaxation in aorta, pulmonary artery and corpus cavernosum produced by BAY K 8644 or N-nitro-L-arginine:
X. Chen and C.N. Gillis; BBRC
186
, 1522 (1992)
Abstract
Possible involvement of nitric oxide in chlordiazepoxide-induced anxiolysis in mice:
R.M. Quock and E. Nguyen; Life Sci.
51
, PL255 (1992)
Abstract
The role of nitric oxide in mediating non-adrenergic non-cholinergic relaxation in longitudinal muscle of human taenia coli:
F.S.-F. Tam & K. Hillier; Life Sci
51
, 1277 (1992)
Abstract
NO- and NO2-carrying molecules potentiate photorelaxation in rat trachea and aorta:
K.C. Chang, et al.; BBRC
191
, 509 (1993)
Abstract
Selective inhibition of constitutive nitric oxide synthase by L-NG- nitroarginine:
E.S. Furfine, et al.; Biochemistry
32
, 8512 (1993)
Abstract
Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor:
Y.A. Kolesnikov, et al.; PNAS
90
, 5162 (1993)
Abstract
Reversible inactivation of endothelial nitric oxide synthase by NG- nitro-L-arginine:
B. Mayer, et al.; FEBS Lett.
333
, 203 (1993)
Abstract
ALX-105-002
Revised 12-Nov-07
NG-Nitro-D-arginine
SYNONYMS
D-NOARG
D-Nitroarginine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers:
Format:
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Unit Price:
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ALX-105-002-M250
250 mg
22.00 USD
ALX-105-002-G001
1 g
53.00 USD
Product Specification
FORMULA:
C
6
H
13
N
5
O
4
MW:
219.2
CAS NUMBER:
66036-77-9
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 0.1M HCl. Moderately soluble in water; insoluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
ALX-105-003
Revised 02-Dec-05
L-NAME . hydrochloride
SYNONYMS
N
G
-Nitro-L-arginine-methyl ester . HCl
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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Product Numbers:
Format:
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ALX-105-003-G005
5 g
32.00 USD
ALX-105-003-G025
25 g
133.00 USD
Product Specification
FORMULA:
C
7
H
15
N
5
O
4
. HCl
MW:
233.2 . 36.5
CAS NUMBER:
51298-62-5
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of nitric oxide synthase (NOS). More soluble than N
G
-Nitro-L-arginine (Prod. No.
ALX-105-001
). Suppresses the release of nitric oxide (NO) from endothelial cells. Has a different effect on the superoxide generation by NOS than L-NMMA (Prod. No.
ALX-106-001
).
Product Specific Literature References
L-NG-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro:
P.K. Moore, et al.; Br. J. Pharmacol.
99
, 408 (1990)
Abstract
Generation of superoxide by purified brain nitric oxide synthase:
S. Pou, et al.; J. Biol. Chem.
267
, 24173 (1992)
Abstract
;
Full Text
ALX-105-004
Revised 02-Dec-05
D-NAME . hydrochloride
SYNONYMS
N
G
-Nitro-D-arginine-methyl ester . HCI
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-004-M250
250 mg
32.00 USD
Product Specification
FORMULA:
C
7
H
15
N
5
O
4
. HCl
MW:
233.2 . 36.5
CAS NUMBER:
50912-92-0
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methanol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inactive isomer of L-NAME (Prod. No.
ALX-105-003
).
ALX-105-009
Revised 06-Jun-06
N-Methyl-D-aspartic acid
SYNONYMS
NMDA
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010
10 mg
23.00 USD
ALX-105-009-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
4
MW:
147.1
CAS NUMBER:
6384-92-5
MERCK INDEX:
14:
6662
RTECS:
CI9457000
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters:
J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol.
21
, 165 (1981), (Review)
Abstract
NMDA receptors and ligands in the vertebrate CNS:
T.W. Stone & N.R. Burton; Progr. Neurobiol.
30
, 333 (1988), (Review)
Abstract
Further Categories Containing This Product:
NMDA Receptors / Related Products
•
Special Amino Acids
ALX-105-010
Revised 04-Dec-04
N-Methyl-L-aspartic acid
SYNONYMS
NMLA
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-010-M010
10 mg
20.00 USD
ALX-105-010-M050
50 mg
50.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
4
MW:
147.1
CAS NUMBER:
4226-18-0
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Further Categories Containing This Product:
Special Amino Acids
ALX-106-001
Revised 30-Nov-06
L-NMMA . monoacetate
SYNONYMS
N
G
-Monomethyl-L-arginine . monoacetate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
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ALX-106-001-M005
5 mg
20.00 USD
ALX-106-001-M025
25 mg
55.00 USD
ALX-106-001-M100
100 mg
180.00 USD
ALX-106-001-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
7
H
16
N
4
O
2
. CH
3
COOH
MW:
188.2 . 60.1
CAS NUMBER:
53308-83-1
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Standard inhibitor of nitric oxide synthase. Suppresses the release of nitric oxide from endothelial cells.
Product Specific Literature References
Identification of arginine as a precursor of endothelium-derived relaxing factor:
I. Sakuma, et al.; PNAS
85
, 8664 (1988)
Abstract
A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation:
D.D. Rees, et al.; Br. J. Pharmacol.
96
, 418 (1989)
Abstract
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase:
M. Palacios-Callender, et al.; PNAS
101
, 7630 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-002
Revised 03-Jun-03
D-NMMA . monoacetate
SYNONYMS
N
G
-Monomethyl-D-arginine . monoacetate
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
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ALX-106-002-M005
5 mg
27.00 USD
ALX-106-002-M025
25 mg
100.00 USD
ALX-106-002-M100
100 mg
280.00 USD
Product Specification
FORMULA:
C
7
H
16
N
4
O
2
. CH
3
COOH
MW:
188.2 . 60.1
CAS NUMBER:
137694-75-8
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-003
Revised 06-Jun-06
L-Citrulline
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
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ALX-106-003-G005
5 g
20.00 USD
Product Specification
FORMULA:
C
6
H
13
N
3
O
3
MW:
175.2
CAS NUMBER:
372-75-8
MERCK INDEX:
14:
2331
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Essential intermediate in the biosynthesis of nitric oxide from L-arginine.
Product Specific Literature References
A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells:
R.M.J. Palmer and S. Moncada; BBRC
158
, 348 (1989)
Abstract
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine:
M. Hecker, et al.; PNAS
87
, 8612 (1990)
Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine:
D.J. Stuehr, et al.; J. Biol. Chem.
266
, 6259 (1991)
Abstract
;
Full Text
ALX-106-004
Revised 11-Jun-08
NG-Hydroxy-L-arginine . monoacetate
SYNONYMS
L-HOArg . AcOH
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-004-M005
5 mg
70.00 USD
ALX-106-004-M025
25 mg
280.00 USD
Product Specification
FORMULA:
C
6
H
14
N
4
O
3
. CH
3
COOH
MW:
190.2 . 60.1
CAS NUMBER:
53598-01-9
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Intermediate in the biosynthesis of nitric oxide from L-arginine by nitric oxide synthases (NOS). Inhibitor of arginases.
Product Specific Literature References
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate:
M.A. Marletta, et al.; Biochemistry
27
, 8706 (1988)
Abstract
P.L. Feldman; THL
32
, 875 (1991), [Synthesis]
On the substrate specificity of nitric oxide synthase:
M. Hecker, et al.; FEBS Lett.
294
, 221 (1991)
Abstract
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine:
D.J. Stuehr, et al.; J. Biol. Chem.
266
, 6259 (1991)
Abstract
;
Full Text
Synthesis and bioactivity of N omega-hydroxyarginine: a possible intermediate in the biosynthesis of nitric oxide from arginine:
G.C. Wallace & J.M. Fukuto; J. Med. Chem.
34
, 1746 (1991), [Synthesis]
Abstract
Nitric oxide and another potent vasodilator are formed from NG-hydroxy- L-arginine by cultured endothelial cells:
A. Zembowicz, et al.; PNAS
88
, 11172 (1991)
Abstract
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery:
G.C. Wallace, et al.; BBRC
176
, 528 (1991)
Abstract
Mechanistic probes of N-hydroxylation of L-arginine by the inducible nitric oxide synthase from murine macrophages:
R.A. Pufahl, et al.; Biochemistry
31
, 6822 (1992), [Synthesis]
Abstract
Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase:
F. Daghigh, et al.; BBRC
202
, 174 (1994)
Abstract
N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase:
J.-L. Boucher, et al.; BBRC
203
, 1614 (1994)
Abstract
Exogenous NG-hydroxyl-L-arginine causes nitrite production in vascular smooth muscle cells in the absence of nitric oxide synthase activity:
C.A. Schott, et al.; FEBS Lett.
341
, 203 (1994)
Abstract
Inhibition of purified nitric oxide synthase from rat cerebellum and macrophage by L-arginine analogs:
Y. Komori, et al.; Arch. Biochem. Biophys.
315
, 213 (1994)
Abstract
Inhibition of arginase by NG-hydroxy-L-arginine in alveolar macrophages: implications for the utilization of L-arginine for nitric oxide synthesis:
M. Hecker, et al.; FEBS Lett.
359
, 251 (1995)
Abstract
Arginase activity in endothelial cells: inhibition by NG-hydroxy-L-arginine during high-output NO production:
G.M. Buga, et al.; Am. J. Physiol.
271
, H1988 (1996)
Abstract
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms:
G.M. Buga, et al.; Am. J. Physiol.
275
, R1256 (1998)
Abstract
;
Full Text
Further Categories Containing This Product:
Arginine & Arginases / Related Products
ALX-106-005
Revised 24-Feb-05
NG, NG-Dimethyl-L-arginine . di(p-hydroxyazobenzene-p'-sulfonate)
SYNONYMS
ADMA . 2HABS
H-Arg(di-Me)-OH . 2HABS (asymmetrical)
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-005-M005
5 mg
23.00 USD
ALX-106-005-M025
25 mg
55.00 USD
Product Specification
FORMULA:
C
8
H
18
N
4
O
2
. 2C
12
H
10
N
2
O
4
S
MW:
202.2 . 556.6
PURITY:
≥97%
APPEARANCE:
Orange powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits nitric oxide synthesis. This salt form is more stable than the dihydrochloride.
Product Specific Literature References
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells:
J.B. Hibbs Jr., et al.; J. Immunol.
138
, 550 (1987)
Abstract
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure:
P. Vallance, et al.; Lancet
339
, 572 (1992), and references cited therein.
Abstract
Further Categories Containing This Product:
PRMTs, Mono- & Dimethylarginine / Related Products
ALX-106-006
Revised 15-Oct-07
NG, NG-Dimethyl-L-arginine . dihydrochloride
SYNONYMS
H-Arg(di-Me)-OH . 2HCl (asymmetrical)
ADMA . 2HCl
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-106-006-M005
5 mg
33.00 USD
ALX-106-006-M025
25 mg
85.00 USD
