ALEXIS Biochemicals: Monoclonal Antibody to Folate Receptor α (Mov18/ZEL)

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ALX-440-041

Revised 25-Nov-04

Aminopterin
SYNONYMS	4-Aminofolic acid 4-Aminopteroylglutamic acid 4-Amino-PGA
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Folic Acid & Folate Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-440-041-M010		10 mg	20.00 USD
ALX-440-041-M050		50 mg	80.00 USD

Product Specification

FORMULA:	C₁₉H₂₀N₈O₅
MW:	440.4
CAS NUMBER:	54-62-6
MERCK INDEX:	14: 472
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in dilute aqeuous base or DMSO; slightly soluble in water or ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HANDLING:	Protect from light.

Product Description

Folic acid antagonist. Potent dihydrofolate reductase inhibitor.

ALX-460-006

Revised 08-Oct-07

Folic acid
SYNONYMS	Pteroylglutamic acid
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Folic Acid & Folate Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-006-G010		10 g	28.00 USD

Product Specification

FORMULA:	C₁₉H₁₉N₇O₆
MW:	441.4
CAS NUMBER:	59-30-3
MERCK INDEX:	14: 4221
PURITY:	≥97%
APPEARANCE:	Yellow to orange powder.
SOLUBILITY:	Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Alkaline solutions are reasonably stable. Other solutions may be light and heat sensitive.

Further Categories Containing This Product:

Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Vitamins

ALX-440-045

Revised 17-Jul-07

Methotrexate
SYNONYMS	(+)-Amethopterin 4-Amino-10-methylfolic acid Methylaminopterin MTX
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Antitumor Agents (Enzyme Inhibitors)

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-440-045-M050		50 mg	25.00 USD
ALX-440-045-M100		100 mg	45.00 USD
ALX-440-045-M500		500 mg	135.00 USD
ALX-440-045-G001		1 g	240.00 USD

Product Specification

FORMULA:	C₂₀H₂₂N₈O₅
MW:	454.5
CAS NUMBER:	59-05-2
MERCK INDEX:	14: 5985
PURITY:	≥98%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.

Product Specific Literature References

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998) Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998) Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998) Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999) Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000) Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000) Abstract

Further Categories Containing This Product:

Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • MDR Other Products • Folic Acid & Folate Receptors / Related Products • DNA Replication Inhibitors

ALX-804-439

Revised 24-Apr-08

Monoclonal Antibody to Folate Receptor α (Mov18/ZEL)
SYNONYMS	anti-FRα MAb (Mov18/ZEL) anti-Folate-binding Protein MAb (Mov18/ZEL) anti-gp38 MAb (Mov18/ZEL)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Folic Acid & Folate Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-439-R100		100 µl	315.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Monkey
CLONE:	Mov18/ZEL
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
PURITY DETAIL:	Purified from concentrated hybridoma cell culture supernatant.
FORMULATION:	Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:	Membrane preparation from a human ovarian carcinoma specimen.
SPECIFICITY:	Recognizes membrane-bound and soluble human and monkey folate receptor (FR) α. Does not cross-react with mouse or rat folate receptor. Does not cross-react with the β-isoform.
APPLICATION:	Flow Cytometry Immunocytochemistry Immunohistochemistry (frozen sections; not recommended for paraffin sections) Immunoprecipitation Western Blot (avoid reducing reagents; use 0.1% SDS in transferring buffer). Note: Suggested starting dilution for the above applications is 1-10µg/ml. Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least one year when stored undiluted at +4°C.
HANDLING:	Avoid freeze/thaw cycles.

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Product Specific Literature References

Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity: S. Miotti, et al.; Int. J. Cancer 39, 297 (1987) Abstract
Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein: L.R. Coney, et al.; Cancer Res. 51, 6125 (1991) Abstract
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues: S.D. Weitman, et al.; Cancer Res. 52, 3396 (1992) Abstract
Effect of hydrostatic pressure and cholesterol depletion on the expression of a tumor-associated antigen: N. Gesmundo, et al.; Eur. J. Biochem. 217, 337 (1993) Abstract
Isolation and biochemical characterization of the soluble and membrane forms of folate binding protein expressed in the ovarian carcinoma cell line IGROV1: A. Tomassetti, et al.; FEBS Lett. 317, 143 (1993) Abstract
Folate binding protein distribution in normal tissues and biological fluids from ovarian carcinoma patients as detected by the monoclonal antibodies MOv18 and MOv19: L.T. Mantovani, et al.; Eur. J. Cancer 30A, 363 (1994) Abstract
Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells: G. Corona, et al.; Int. J. Cancer 75, 125 (1998) Abstract
Molecular requirements for attachment of the glycosylphosphatidylinositol anchor to the human alpha folate receptor: A. Tomassetti, et al.; J. Cell Biochem. 72, 111 (1999) Abstract

General Information

The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas.

Further Categories Containing This Product:

Monoclonal Antibodies • Tumor Markers

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