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Recombinant Proteins / Fusion Proteins
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ALX-522-055 Revised 24-Mar-05
DcR3 (human):Fc (human) (recombinant)
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SYNONYMS Decoy Receptor 3 (human):Fc (human) (recombinant)
TNFRSF 6B (human):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY HVEM & LIGHT / LT-betaR / DcR3 / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-055-C050   50 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW: ~58kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml after reconstitution.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water.
SPECIFICITY: Binds human LIGHT. Does not bind human FasL.
APPLICATION: Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer: R.M. Pitti, et al.; Nature 396, 699 (1998) Abstract
A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis: K.Y. Yu, et al.; J. Biol. Chem. 274, 13733 (1999) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O95407: DcR3 (human) (precursor)
AfCS Signalling Gateway link A000758: DcR3 (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Soluble decoy receptor 3 is expressed by malignant gliomas and suppresses CD95 ligand-induced apoptosis and chemotaxis: W. Roth, et al.; Cancer Res. 61, 2759 (2001) Abstract
Modulation of dendritic cell differentiation and maturation by decoy receptor 3: T.L. Hsu, et al.; J. Immunol. 168, 4846 (2002) Abstract
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Recombinant Proteins / Fusion Proteins
 
 
ALX-201-427 Revised 19-Nov-08 New product
Dlk1 (human):Fc (human) (recombinant)
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SYNONYMS Delta-like Protein (DLK) (human):Fc (human) (recombinant)
Pref-1 (human):Fc (human) (recombinant)
Preadipocyte Factor 1 (human):Fc (human) (recombinant)
Fetal Antigen 1 (FA1) (human):Fc (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-427-C010   10 µg 250.00 USD Add To Cart
ALX-201-427-C050   50 µg 660.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the extracellular domain of human Dlk1 (aa 1-303) is fused at the C-terminus to the Fc portion of human IgG.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P80370: DLK (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Delta-like [DLL] & Jagged / Related Products • Recombinant Proteins / Fusion Proteins • Cell Differentiation
 
 
ALX-201-416 Revised 09-Jul-08
Dlk1 (mouse):Fc (human) (recombinant)
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SYNONYMS Delta-like Protein (DLK) (mouse):Fc (human) (recombinant)
Pref-1 (mouse):Fc (human) (recombinant)
Preadipocyte Factor 1 (mouse):Fc (human) (recombinant)
Fetal Antigen 1 (FA1) (mouse):Fc (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-416-C010   10 µg 250.00 USD Add To Cart
ALX-201-416-C050   50 µg 570.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide and the extracellular domain of mouse Dlk1 (aa 1-305) is fused at the C-terminus to the Fc portion of human IgG.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q09163: DLK (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Delta-like [DLL] & Jagged / Related Products • Recombinant Proteins / Fusion Proteins • Cell Differentiation
 
 
ALX-201-382 Revised 24-Jul-08
DLL1 (human) (recombinant)
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SYNONYMS Delta-like Protein 1 (human) (recombinant)
Delta1 (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Delta-like [DLL] & Jagged / Related Products
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ALX-201-382-C010   10 µg 295.00 USD Add To Cart
ALX-201-382-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of recombinant human DLL1 (Delta-like protein 1; Delta1) (aa 1-545) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:

PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
Notch signalling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands are divided into two subclasses, the delta and the serrate family [1]. Delta-like 1, 3, and 4 (DLL1, -3, -4), JAG1 and JAG2 with DSL (Delta, Serrate, Lag2) domain are typical Notch ligands, while DNER, F3/Contactin and NB-3 without DSL domain are atypical Notch ligands. Notch-ligand binding to NOTCH1, -2, -3, or -4 receptor induces the receptor proteolysis by metalloprotease and γ-secretase to release Notch intracellular domain (NICD).
DLL1 [1] is the human homolog of the Drosophila Notch ligand Delta [2]. Sequence analysis predicted that the 723-aa DLL1 transmembrane protein, which is 88% identical to the mouse DLL1 protein [3], has a DSL domain followed by 8 tandem EGF-like repeats and a short cytoplasmic C-terminal region. A soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal aa inhibited the differentiation of myeloid progenitors but promoted their expansion [4]. DLL1 blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor [5]. DLL1 undergoes proteolytic processing in its extracellular domain by ADAM10 and represents a substrate for several other members of the ADAM family [6, 7]. The soluble 38kDa Delta1 intracellular domain (DICD) that is generated by the presenilin-dependent γ-secretase cleavage is transported into the nucleus and likely plays a role in transcriptional events [8-10]. Recently it has been shown that DLL1 is essential for postnatal arteriogenesis [11].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O00548: DLL1 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] Human ligands of the Notch receptor: G.E. Gray, et al.; Am. J. Pathol. 154, 785 (1999) Abstract; Full Text
[2] The molecular genetics of early neurogenesis in Drosophila melanogaster: E. Knust and J.A. Campos-Ortega; Bioessays 11, 95 (1989) Abstract
[3] Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta: B. Bettenhausen, et al.; Development 121, 2407 (1995) Abstract; Full Text
[4] A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells: W. Han, et al.; Blood 95, 1616 (2000) Abstract; Full Text
[5] Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation: A.C. Jaleco, et al.; J. Exp. Med. 194, 991 (2001) Abstract; Full Text
[6] The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase: E. Six, et al.; PNAS 100, 7638 (2003) Abstract; Full Text
[7] Proteolytic processing of delta-like 1 by ADAM proteases: E. Dyczynska, et al.; J. Biol. Chem. 282, 436 (2007) Abstract; Full Text
[8] Notch-induced proteolysis and nuclear localization of the Delta ligand: C.E. Bland, et al.; J. Biol. Chem. 278, 13607 (2003) Abstract; Full Text
[9] The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage: T. Ikeuchi and S.S. Sisodia; J. Biol. Chem. 278, 7751 (2003) Abstract; Full Text
[10] The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments: M.J. LaVoie and D.J. Selkoe; J. Biol. Chem. 278, 34427 (2003) Abstract; Full Text
[11] The Notch Ligand Delta-Like 1 is Essential for Postnatal Arteriogenesis: A. Limbourg, et al.; Circ. Res. 100, 363 (2007) Abstract
[12] NOTCH signaling as a novel cancer therapeutic target: L. Miele, et al.; Curr. Cancer Drug Targets 6, 313 (2006) Abstract
[13] Notch signaling in gastrointestinal tract: M. Katoh; Int. J. Oncol. 30, 247 (2007), Review Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-425 Revised 24-Sep-08 New product
DLL1 (human):Fc (human) (recombinant)
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SYNONYMS Delta-like Protein 1 (human):Fc (human) (recombinant)
Delta1 (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Delta-like [DLL] & Jagged / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-425-C010   10 µg 230.00 USD Add To Cart
ALX-201-425-C050   50 µg 690.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of recombinant human DLL1 (Delta-like protein 1; Delta1) (aa 1-545) is fused at the C-terminus to the Fc portion of human IgG.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Notch signalling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands are divided into two subclasses, the delta and the serrate family [1]. Delta-like 1, 3, and 4 (DLL1, -3, -4), JAG1 and JAG2 with DSL (Delta, Serrate, Lag2) domain are typical Notch ligands, while DNER, F3/Contactin and NB-3 without DSL domain are atypical Notch ligands. Notch-ligand binding to NOTCH1, -2, -3, or -4 receptor induces the receptor proteolysis by metalloprotease and γ-secretase to release Notch intracellular domain (NICD).
DLL1 [1] is the human homolog of the Drosophila Notch ligand Delta [2]. Sequence analysis predicted that the 723-aa DLL1 transmembrane protein, which is 88% identical to the mouse DLL1 protein [3], has a DSL domain followed by 8 tandem EGF-like repeats and a short cytoplasmic C-terminal region. A soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal aa inhibited the differentiation of myeloid progenitors but promoted their expansion [4]. DLL1 blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK cell precursor [5]. DLL1 undergoes proteolytic processing in its extracellular domain by ADAM10 and represents a substrate for several other members of the ADAM family [6, 7]. The soluble 38kDa Delta1 intracellular domain (DICD) that is generated by the presenilin-dependent γ-secretase cleavage is transported into the nucleus and likely plays a role in transcriptional events [8-10]. Recently it has been shown that DLL1 is essential for postnatal arteriogenesis [11].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O00548: DLL1 (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] Human ligands of the Notch receptor: G.E. Gray, et al.; Am. J. Pathol. 154, 785 (1999) Abstract; Full Text
[2] The molecular genetics of early neurogenesis in Drosophila melanogaster: E. Knust and J.A. Campos-Ortega; Bioessays 11, 95 (1989) Abstract
[3] Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta: B. Bettenhausen, et al.; Development 121, 2407 (1995) Abstract; Full Text
[4] A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells: W. Han, et al.; Blood 95, 1616 (2000) Abstract; Full Text
[5] Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation: A.C. Jaleco, et al.; J. Exp. Med. 194, 991 (2001) Abstract; Full Text
[6] The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase: E. Six, et al.; PNAS 100, 7638 (2003) Abstract; Full Text
[7] Proteolytic processing of delta-like 1 by ADAM proteases: E. Dyczynska, et al.; J. Biol. Chem. 282, 436 (2007) Abstract; Full Text
[8] Notch-induced proteolysis and nuclear localization of the Delta ligand: C.E. Bland, et al.; J. Biol. Chem. 278, 13607 (2003) Abstract; Full Text
[9] The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage: T. Ikeuchi and S.S. Sisodia; J. Biol. Chem. 278, 7751 (2003) Abstract; Full Text
[10] The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments: M.J. LaVoie and D.J. Selkoe; J. Biol. Chem. 278, 34427 (2003) Abstract; Full Text
[11] The Notch Ligand Delta-Like 1 is Essential for Postnatal Arteriogenesis: A. Limbourg, et al.; Circ. Res. 100, 363 (2007) Abstract
[12] NOTCH signaling as a novel cancer therapeutic target: L. Miele, et al.; Curr. Cancer Drug Targets 6, 313 (2006) Abstract
[13] Notch signaling in gastrointestinal tract: M. Katoh; Int. J. Oncol. 30, 247 (2007), Review Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-422 Revised 09-Jun-08 New product
DLL3 (human):Fc (human) (recombinant)
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SYNONYMS Delta-like Protein 3 (human):Fc (human) (recombinant)
Delta3 (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Delta-like [DLL] & Jagged / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-422-C010   10 µg 300.00 USD Add To Cart
ALX-201-422-C050   50 µg 830.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of recombinant human DLL3 (aa 1-466) is fused at the C-terminus to the Fc portion of human IgG1.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9NYJ7: DLL3(human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-386 Revised 26-May-08
DLL4 (human):Fc (human) (recombinant)
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SYNONYMS Delta-like Protein 4 (human):Fc (human) (recombinant)
Delta4 (human):Fc (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Delta-like [DLL] & Jagged / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-386-C010   10 µg 310.00 USD Add To Cart
ALX-201-386-C050   50 µg 860.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and extracellular domain of recombinant human DLL4 (Delta-like protein 4; Delta4) (aa 1-529) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:

PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
Notch signalling pathways play key roles in cell-fate determination and differentiation in many tissues during embryonic and postnatal development. Notch ligands are divided into two subclasses, the delta and the serrate family [1]. DLL4 (Dll4) is a novel delta family member and exhibits all the hallmarks of the delta family of Notch ligands [2]. Human DLL4 shares 86% aa sequence identity with mouse Dll4. The extracellular region of the 685 aa protein contains 8 EGF-like repeats as well as a DSL (Delta, Serrate, Lag2) domain necessary for receptor binding. The protein also contains a transmembrane domain and a cytoplasmic tail lacking any catalytic motifs. DLL4 is largely restricted to the vascular endothelium and has been shown to function as a ligand for Notch1 and Notch4 [3]. Signalling through Notch1 regulates formation of tip cells during angiogenesis [4].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9NR61: DLL4 (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] Human ligands of the Notch receptor: G.E. Gray, et al.; Am. J. Pathol. 154, 785 (1999) Abstract
[2] Dll4, a novel Notch ligand expressed in arterial endothelium: J.R. Shutter, et al.; Genes Dev. 14, 1313 (2000) Abstract
[3] Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting: I.B. Lobov, et al.; PNAS 104, 3219 (2007) Abstract
[4] Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis: M. Hellstrom, et al.; Nature 445, 776 (2007) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-278 Revised 30-Sep-08
DNA Ligase I (human) (recombinant) (His)