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ALX-210-313
Revised 14-Nov-06
Polyclonal Antibody to Bone Sialoprotein (human)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Matrix Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-313-R020
20 µl
135.00 USD
ALX-210-313-R100
100 µl
660.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 20µl/100µl distilled water.
IMMUNOGEN:
Synthetic peptide corresponding to aa 262-279 (Y
262
ESENGEPRGDNYRAYED
279
) of human bone sialoprotein.
SPECIFICITY:
Recognizes human bone sialoprotein. Does not cross-react with human osteonectin or osteopontin.
APPLICATION:
ELISA (1:1'000)
Immunocytochemistry (1:100)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-537
Revised 10-Apr-08
Polyclonal Antibody to CD51
SYNONYMS
anti-αV Integrin PAb
Polyclonal Antibody to Vitronectin Receptor (α Subunit)
anti-Vitronectin Receptor (α Subunit) PAb
PRODUCT LINE
Immunology
PRODUCT CATEGORY
CD Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-537-R100
100 µl
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Dog
Pig
Monkey
SOURCE/HOST:
From rabbit.
PURITY:
Liquid. Neat serum containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
SPECIFICITY:
Recognizes cytoplasmic domain of CD51 of all species.
APPLICATION:
ELISA
Immunocytochemistry (1:1’000)
Immunohistochemistry (1:1’000)
Immunoprecipitation (5µl per 5x10
6
cells)
Western Blot (1:5’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development:
E. Hirsch, et al.; Dev. Dyn.
201
, 108 (1994)
Abstract
General Information
CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3 is also highly expressed in osteoclasts being important for bone resorption.
Further Categories Containing This Product:
Angiogenesis Other Products
•
Integrins / Related Products
•
Polyclonal Antibodies
•
Bone Metabolism Other Products
ALX-210-397
Revised 01-Apr-08
Polyclonal Antibody to Midkine (human)
SYNONYMS
anti-RIHB (human) PAb
anti-Neurite Outgrowth-promoting Factor 2 (human) PAb
anti-Amphiregulin-associated Protein (human) PAb
anti-ARAP (human) PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Heparin Binding Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-397-C050
50 µg
399.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY DETAIL:
Affinity purified.
FORMULATION:
Lyophilized from sterile filtered solution in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION:
Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN:
Recombinant human midkine.
SPECIFICITY:
Recognizes human midkine.
APPLICATION:
ELISA
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Midkine is a retinoic acid inducible heparin binding protein. Midkine promotes neuronal survival and neurite outgrowth and plays a role in carcinogenesis and tissue remodeling. Midkine expression is induced during remodeling after bone fractures.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-398
Revised 01-Jun-06
Polyclonal Antibody to Osteoblast Specific Factor 1 (human)
SYNONYMS
anti-OSF-1 (human) PAb
anti-Pleiotrophin (human) PAb
anti-HB-GAM (human) PAb
anti-HARP (human) PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Heparin Binding Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-398-C050
50 µg
430.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
FORMULATION:
Lyophilized from sterile filtered solution of affinity purified antibody in 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride.
RECONSTITUTION:
Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN:
Recombinant human OSF-1 (osteoblast specific factor 1).
SPECIFICITY:
Recognizes human OSF-1.
APPLICATION:
Immunohistochemistry
ELISA
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
OSF-1 is an extracellular matrix-associated protein, present in matrices, which act as targets for the deposition of new bone. OSF-1 has the ability to promote adhesion, migration, expansion and differentation of human osteoprogenitor cells.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-399
Revised 30-Sep-08
Polyclonal Antibody to Osteoblast Specific Factor 2
SYNONYMS
anti-OSF-2 PAb
anti-Periostin PAb
anti-Fasciclin-I-like PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Heparin Binding Factors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-399-C050
50 µg
430.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
PURITY DETAIL:
Affinity purified.
FORMULATION:
Lyophilized from 0.05M phosphate buffer, pH 7.2, containing 0.1M sodium chloride. Contains no preservatives.
RECONSTITUTION:
Reconstitute with 50µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN:
Recombinant human OSF-2 (osteoblast specific factor 2).
SPECIFICITY:
Recognizes human, mouse, rat and chicken OSF-2.
APPLICATION:
ELISA
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100-1:5'000))
Western Blot (0.1-1µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Product Specific Literature References
Identification and location of bone-forming cells within cartilage canals on their course into the secondary ossification centre:
M.J. Blumer, et al.; J. Anat.
208
, 695 (2006)
Abstract
A chemical proteomics approach for the identification of accessible antigens expressed in human kidney cancer:
V. Castronovo, et al.; Mol. Cell. Proteomics
5
, 2083 (2006)
Abstract
;
Full Text
Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data:
A. Grigoriadis, et al.; Breast Cancer Res.
8
, R56 (2006)
Abstract
;
Full Text
Immunohistochemical localization of alpha-Smooth muscle actin during rat molar tooth development:
A. Hosoya, et al.; J. Histochem. Cytochem.
54
, 1371 (2006)
Abstract
Quantification of membrane and membrane-bound proteins in normal and malignant breast cancer cells isolated from the same patient with primary breast carcinoma:
X. Liang, et al.; J. Proteome Res.
5
, 2632 (2006)
Abstract
ANP signaling inhibits TGF-beta-induced Smad2 and Smad3 nuclear translocation and extracellular matrix expression in rat pulmonary arterial smooth muscle cells:
P. Li, et al.; J. Appl. Physiol.
102
, 390 (2007)
Abstract
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity:
M. Erkan, et al.; Gastroenterology
132
, 1447 (2007)
Abstract
General Information
OSF-2 functions as a cell-adhesion molecule for pro-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Patients with bone metastases from breast (but not lung) cancer show elevated levels of OSF-2. OSF-2 expression is significantly increased by bone morphogenetic protein 2 (BMP-2).
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-308
Revised 17-Jul-07
Polyclonal Antibody to Osteocalcin (human) (NT)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-308-R020
20 µl
115.00 USD
ALX-210-308-R100
100 µl
486.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 20µl/100µl distilled water.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-22 (Y
1
LYQWLGAPVPYP
DPLEPRREV
22
) of human mature osteocalcin.
SPECIFICITY:
Recognizes human osteocalcin. Does not cross-react with human osteopontin, human osteonectin, human bone sialoprotein or bovine or sheep osteocalcin.
APPLICATION:
ELISA (1:5'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-333
Revised 24-Jul-08
Polyclonal Antibody to Osteocalcin (NT) (mouse)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-333-C100
100 µg
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml after reconstitution.
PURITY DETAIL:
Protein A-affinity and epitope-affinity purified.
FORMULATION:
Lyophilized from 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
RECONSTITUTION:
Reconstitute with 50µl distilled water. Dilute with 10mM PBS, pH 7.4, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-20 (Y
1
LGASVPSPDP
LEPTREQCE
20
) of intracellular N-terminal mouse osteocalcin.
SPECIFICITY:
Recognizes intracellular N-terminal mouse osteocalcin. Does not cross-react with rat osteocalcin.
APPLICATION:
Immunohistochemistry (paraffin sections (1-2µg/ml))
Note:
Not suitable for Western blot.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Reconstituted solution can be stored at +4°C for 6 months and at -20°C for 1 year.
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-343
Revised 25-Aug-05
Polyclonal Antibody to Osteoinductive Factor (human)
SYNONYMS
anti-OIF (human) PAb
anti-Osteoglycine (human) PAb
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Bone Metabolism Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-343-R020
20 µl
161.00 USD
ALX-210-343-R100
100 µl
693.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with double distilled water.
IMMUNOGEN:
Synthetic peptide corresponding to aa 108-122 (R
108
FNKIKKLTAKDFAD
122
) of human OIF (osteoinductive factor).
SPECIFICITY:
Recognizes human OIF. Does not cross-react with human bone sialoprotein or osteopontin.
APPLICATION:
ELISA (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-309
Revised 26-Mar-08
Polyclonal Antibody to Osteopontin (human)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Matrix Proteins Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-309-R020
20 µl
150.00 USD
ALX-210-309-R100
100 µl
660.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml after reconstitution.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with 20µl or 100µl distilled water.
IMMUNOGEN:
Synthetic peptide corresponding to aa 59-74 (P
59
SKSNESHDHMDDMDD
74
) of mature human osteopontin.
SPECIFICITY:
Recognizes human osteopontin. Does not cross-react with human osteonectin or bone sialoprotein.
APPLICATION:
ELISA (1:1’000)
Immunohistochemistry (paraffin sections (1:1’500))
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-945
Revised 20-Jun-08
Polyclonal Antibody to Osteoprotegerin (human) (AT121)
SYNONYMS
anti-OPG (human) MAb (AT121)
anti-TNFRSF 11B (human) MAb (AT121)
anti-Osteoclastogenesis Inhibitory Factor (human) MAb (AT121)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
OPG
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-945-C100
100 µg
310.00 USD
ALX-210-945B-C100
Biotin
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human osteoprotegerin (OPG) cysteine-rich region (aa 22-202) (Prod. No.
ALX-522-007
).
SPECIFICITY:
Recognizes human OPG.
APPLICATION:
ELISA
Immunoprecipitation (1:200)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases:
M. Baud’huin, et al.; Cell. Mol. Life Sci.
64
, 2334 (2007)
Abstract
Related Products
ALX-522-007
Osteoprotegerin (human):Fc (human) (recombinant)
ALX-804-813
Monoclonal Antibody to Osteoprotegerin (human) (Bony-1)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-310
Revised 25-Jan-05
Polyclonal Antibody to Osteostatin (human)
PRODUCT LINE
Bone Metabolism
PRODUCT CATEGORY
Bone Metabolism Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-310-R020
20 µl
150.00 USD
ALX-210-310-R100
100 µl
660.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with distilled water (20µl for
ALX-210-310
-R020, 100µl for -R100).
IMMUNOGEN:
Synthetic peptide corresponding to aa 107-111 (T
107
RSAW
111
) of human PTHrP (parathyroid hormone-related protein).
SPECIFICITY:
Recognizes human osteostatin.
APPLICATION:
ELISA (1:5'000)
