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CC Chemokines & Receptors / Related Products
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ALX-210-620 Revised 25-Jan-07
Polyclonal Antibody to CCR1 (human)
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SYNONYMS anti-C-C Chemokine Receptor 1 (human) PAb
anti-CD191 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-620-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 7-24 (T7EDYDTTTEFDY
GDATPC24) of the N-terminal extracellular domain of human CCR1 (C-C chemokine receptor 1).
SPECIFICITY: Recognizes human CCR1. Does not cross-react with mouse CCR1.
APPLICATION: Immunocytochemistry (1:400)
Western Blot  (1:1’000)
QUALITY CONTROL: Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-019.
Product Description
CCR1 is a receptor for macrophage inflammatory protein-1α (MIP-1α) and RANTES, expressed in peripheral blood lymphocytes and monocytes (but not neutrophils). The antibody is useful in determining the number of CCR1 positive cells and in detecting any changes in the level of CCR1 expression in cells present at the site of inflammation.
General Literature References
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor: K. Neote, et al.; Cell 72, 415 (1993) Abstract
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Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-621 Revised 31-Jul-07
Polyclonal Antibody to CCR4 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 4 (mouse) PAb
anti-CD194 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-621-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified F(ab`)2 fragment.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNS
YYFYESMP26C) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4).
SPECIFICITY: Recognizes mouse CCR4. Does not cross-react with human CCR4.
APPLICATION: Flow Cytometry (1-3µl per 2x105 cells per 50µl)
Immunocytochemistry (1:500)
Western Blot  (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-020.
General Information
Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-622 Revised 31-Jul-07
Polyclonal Antibody to CCR4 (human)
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SYNONYMS anti-C-C Chemokine Receptor 4 (human) PAb
anti-CD194 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-622-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 18-39 (S18NYYLYESIPK
PCTKEGIKAFGE39) of human CCR4 (C-C chemokine receptor 4).
SPECIFICITY: Recognizes human CCR4.
APPLICATION: Immunocytochemistry (acetone fixed cells (1:400))
Immunohistochemistry (paraffin sections (1:200))
Western Blot  (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-061.
Product Images
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General Information
Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-640 Revised 25-Sep-07
Polyclonal Antibody to CCR2 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 2 (mouse) PAb
anti-CD192 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-640-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 18-45 (S18HSLFTRSIQELDEGATTPYDYDDGEPC45) of the N-terminal extracellular domain of mouse CCR2 (C-C chemokine receptor 2).
SPECIFICITY: Recognizes mouse CCR2.
APPLICATION: Immunocytochemistry (1:400)
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-065.
Product Images
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Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-641 Revised 25-Sep-07
Polyclonal Antibody to CCR3 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 3 (mouse) PAb
anti-Eotaxin Receptor (mouse) PAb
anti-CD193 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-641-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 5-29 (T5DEIKTVVESFETTPYEYEWAPPC28) of the N-terminal extracellular domain of mouse CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY: Recognizes mouse CCR3.
APPLICATION: Immunocytochemistry (>1:400)
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-066.
Product Images
Please click on thumbnails to enlarge.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-741 Revised 25-Jan-07
Polyclonal Antibody to CCR1 (human)
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SYNONYMS anti-C-C Chemokine Receptor 1 (human) PAb
anti-CD191 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-741-R100   100 µl 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY DETAIL: Epitope-affinity purified F(ab`)2 fragments.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 7-24 (T7EDYDTTTEFDY
GDATPC24) of the N-terminal extracellular domain of human CCR1 (C-C chemokine receptor 1).
SPECIFICITY: Recognizes human CCR1. Does not cross-react with mouse CCR1.
APPLICATION: Immunocytochemistry (1:400)
Immunohistochemistry (paraffin sections)
Western Blot (1:1’000)
Optimal working conditions must be determined individually for each application.
QUALITY CONTROL: Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-019.
Product Description
CCR1 is a receptor for macrophage inflammatory protein-1α (MIP-1α) and RANTES, expressed in peripheral blood lymphocytes and monocytes (but not neutrophils). The antibody is useful in determining the number of CCR1 positive cells and in detecting any changes in the level of CCR1 expression in cells present at the site of inflammation.
Product Specific Literature References
Preparation of specific polyclonal antibodies to a C-C chemokine receptor, CCR1, and determination of CCR1 expression on various types of leukocytes: S.B. Su, et al.; J. Leukoc. Biol. 60, 658 (1996) Abstract
General Literature References
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor: K. Neote, et al.; Cell 72, 415 (1993) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-742 Revised 31-Jul-07
Polyclonal Antibody to CCR4 (mouse)
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SYNONYMS anti-C-C Chemokine Receptor 4 (mouse) PAb
anti-CD194 (mouse) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-742-R100   100 µl 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Epitope-affinity purified F(ab)2 fragment.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 8-26 (D8TTQDETVYNSYYFY
ESMP26) of the N-terminal extracellular domain of mouse CCR4 (C-C chemokine receptor 4).
SPECIFICITY: Recognizes mouse CCR4. Does not cross-react with human CCR4.
APPLICATION: Immunocytochemistry (1:500)
Immunohistochemistry (paraffin sections)
Western Blot (1:1’000)
QUALITY CONTROL: Immunocytochemistry on mouse spleen cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-020.
Product Specific Literature References
Dendritic cell immunization route determines CD8+ T cell trafficking to inflamed skin: role for tissue microenvironment and dendritic cells in establishment of T cell-homing subsets: J.C. Dudda, et al.; J. Immunol. 172, 857 (2004) Abstract
General Information
Mouse CCR4 is the homolog of human CCR4 receptor (85% identical), binding macrophage inflammatory protein-1α (MIP-1α) and RANTES. Mouse CCR4 transcripts are expressed in the thymus and in T-cell lines.
General Literature References
Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4: A. Hoogewerf, et al.; BBRC 218, 337 (1996) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies • CD Antibodies
 
 
ALX-210-762 Revised 25-Jan-07
Polyclonal Antibody to CCR8 (human) (NT)
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SYNONYMS anti-C-C Chemokine Receptor 8 (human) (NT) PAb
anti-CD198 (human) (NT) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-762-C200   200 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 2mg/ml
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 12-36 (V12TDYYYPDIFSSPCDAELIQTNGKL36) of the N-terminal extracellular domain of human CCR8 (C-C chemokine receptor 8).
SPECIFICITY: Recognizes human CCR8.
APPLICATION: Flow Cytometry (2-5µl per 106 cells/50-100µl)
Immunocytochemistry (acetone fixed cells (1:800))
Immunohistochemistry (paraffin sections (1:250))
Western Blot (1:2’000)
Functional Application (neutralizing; inhibits Lp(a) induced MCA in HUVECS)
QUALITY CONTROL: Immunocytochemistry on human K562 cells and immunohistochemistry on human spleen tissue slices.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-024.
Product Specific Literature References
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains: R. Horuk, et al.; J. Biol. Chem. 273, 386 (1998) Abstract; Full Text
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor: M. Samson, et al.; Eur. J. Immunol. 26, 3021 (1996) Abstract
CC Chemokine I-309 is the Principal Monocyte Chemottractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells: N.S. Haque; Circulation 102, 786 (2000) Abstract
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium: N.S. Haque; Blood 97, 39 (2001) Abstract
CCL16 activates an angiogenic program in vascular endothelial cells: M. Strasly, et al.; Blood 103, 40 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemistry on paraffin sections:
Fix paraffin sections in 10% formalin. De-wax sections and block endogenous peroxide by incubating sections with 3% H2O2 for 15 min. at room temperature (RT).  Wash sections with PBS and incubate with 2% normal rabbit serum at room temperature to block non-specific binding sites.  Wash sections with PBS and incubate with primary antibody (anti-chemokine receptor) at recommended dilution for 60 min. at RT.  Wash slides and incubate at RT with biotinylated rabbit anti-goat IgG H+L (Vector Labs) at 1:200 dilution for 30 min.  Wash slides and incubate with HRP-Streptavidin (Vector Labs) 1:400 dilution for 30 min.  Wash slides and incubate with DAB for 5-7 min. at RT.  Wash slides with PBS and counter stain with hematoxylin.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-764 Revised 24-Jan-07
Polyclonal Antibody to CCR8 (human)
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SYNONYMS anti-C-C Chemokine Receptor 8 (human) PAb
anti-CD198 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-764-C100   100 µg 340.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From goat.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 184-193 (Y184SFYNQQTLK193) of the 2nd extracellular domain of human CCR8 (C-C Chemokine Receptor 8).
SPECIFICITY: Recognizes human CCR8.
APPLICATION: Immunocytochemistry (acetone fixed cells (1:800))
Immunohistochemistry (paraffin sections (1:300))
Western Blot (1:2'000)
QUALITY CONTROL: Immunocytochemistry on human K562 cells.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE: For Blocking Peptide see Prod. No. ALX-153-025.
Product Specific Literature References
Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor: M. Samson, et al.; Eur. J. Immunol. 26, 3021 (1996) Abstract
The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains: R. Horuk, et al.; J. Biol. Chem. 273, 386 (1998) Abstract; Full Text
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium: N.S. Haque, et al.; Blood 97, 39 (2001) Abstract; Full Text
CC Chemokine I-309 is the Principal Monocyte Chemoattractant Induced by Apolipoprotein(a) in Human Vascular Endothelial Cells: N.S. Haque, et al.; Circulation 102, 786 (2000) Abstract; Full Text
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL: N.E. Annels, et al.; Blood 103, 2806 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemistry on paraffin sections:

Fix paraffin sections in 10% formalin.  De-wax sections and block endogenous peroxide by incubating sections with 3% H2O2 for 15 minutes at room temperature (RT).  Wash sections with PBS and incubate with 2% normal rabbit serum at room temperature to block the non-specific binding sites.  Wash  sections with PBS and incubate with primary antibody (anti-chemokine receptor) at recommended dilution for 60 minutes at RT.  Wash slides and incubate at RT with biotinylated rabbit anti-goat IgG H+L (Vector Labs) at 1:200 dilution for 30 minutes.  Wash slides and incubate with HRP-Streptavidin (Vector Labs) 1:400 dilution for 30 minutes.  Wash slides and incubate with DAB for 5-7 minutes at RT.  Wash slides with PBS and counter stain with hematoxylin.

Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-821 Revised 12-Apr-06
Polyclonal Antibody to CCR2 (human)
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SYNONYMS anti-C-C Chemokine Receptor 2 (human) PAb
anti-CD192 (human) PAb
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers: Format: