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ALX-380-262 Revised 09-Apr-08
Amidepsine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-262-M001   1 mg 230.00 USD Add To Cart
ALX-380-262-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C29H29NO11
MW: 567.6
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: Pale white to pale yellow powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
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Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-380-263 Revised 09-Apr-08
Amidepsine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-263-M001   1 mg 230.00 USD Add To Cart
ALX-380-263-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C26H24O10
MW: 496.5
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light pink powder.
SOLUBILITY: Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5µM) and Raji cells (IC50=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
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Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-350-149 Revised 23-Oct-07
Cylindrospermopsin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-149-C025   25 µg 140.00 USD Add To Cart
ALX-350-149-C100   100 µg 210.00 USD Add To Cart
Product Specification
FORMULA: C15H21N5O7S
MW: 415.4
CAS NUMBER: 143545-90-8
RTECS: UV9104310
SOURCE/HOST: Isolated from Cylindrospermopsis raciborskii.
PURITY: ≥95% (HPLC)
APPEARANCE: Glassy solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. HIGHLY IRRITANT.

Product Description
Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.
Product Specific Literature References
Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir: P.R. Hawkins, et al.; Appl. Environ. Microbiol. 50, 1292 (1985) Abstract; Full Text
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii: I. Ohtani, et al.; JACS 114, 7941 (1992) Full Text
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake: P.R. Hawkins, et al.; Toxicon. 35, 341 (1997) Abstract
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity: G.R. Shaw, et al.; Ther. Drug Monit. 22, 89 (2000) Abstract
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin: I.R. Falconer & A.R. Humpage; Environ. Toxicol. 16, 192 (2001) Abstract
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin: D.J. Griffiths and M.L. Saker; Environ. Toxicol. 18, 78 (2003), Review Abstract
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice: M. Reisner, et al.; Toxicol. Sci. 82, 620 (2004) Abstract
Further Categories Containing This Product:
Alkaloids • Uridine Derivatives Other Products • Protein Synthesis Other Products • Lipid Metabolism Other Products • Marine Natural Products
 
 
ALX-201-421 Revised 14-Oct-08 New product
FTO (human) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (human) (recombinant) (His)
FATSO (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
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ALX-201-421-C010   10 µg 230.00 USD Add To Cart
ALX-201-421-C050   50 µg 510.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of human FTO (aa 2-505) is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9C0B1: FTO (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid Res. 49, 607 (2008) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Metabolism Other Products
 
 
ALX-201-436 Revised 14-Oct-08 New product
FTO (mouse) (recombinant) (His)
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SYNONYMS Fat Mass and Obesity-associated Protein (mouse) (recombinant) (His)
FATSO (mouse) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Obesity & Diabetes Other Products
Ordering Information
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ALX-201-436-C010   10 µg 240.00 USD Add To Cart
ALX-201-436-C050   50 µg 540.00 USD Add To Cart
Product Specification
SOURCE/HOST: Expressed in E. coli. The mature peptide of mouse FTO (aa 2-502) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
The FTO (fat mass and obesity-associated) gene is well conserved and found in a single copy in vertebrate species. It is suggested that the FTO protein plays a role in fat cell lipolysis, which may be important in explaining why the FTO gene (and FTO gene variants) is implicated in body weight regulation.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8BGW1: FTO (mouse)
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity: T.M. Frayling, et al.; Science 316, 889 (2007) Abstract
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase: T. Gerken, et al.; Science 318, 1469 (2007) Abstract
The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis: K. Wahlen, et al.; J. Lipid. Res. 49, 607 (2007) Abstract
The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain: R. Fredriksson, et al.; Endocrinology 149, 2062 (2008) Abstract
Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans: N. Klöting, et al.; Diabetologia 51, 641 (2008) Abstract
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes: J.A. Jacobsson, et al.; BBRC 368, 476 (2008) Abstract
Regulation of Fto/Ftm gene expression in mice and humans: G. Stratigopoulos, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1185 (2008) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Lipid Metabolism Other Products
 
 
ALX-380-265 Revised 09-Apr-08
Hymeglusin
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SYNONYMS 1233A
F-244
(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxooxetan-2-yl]-3,5,7-trimethylundeca-2,4-dienoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-265-M001   1 mg 230.00 USD Add To Cart
ALX-380-265-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C18H28O5
MW: 324.4
CAS NUMBER: 9027-44-5
SOURCE/HOST: Isolated from fungal strain Scopulariopsis sp. F-244.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous solid.
SOLUBILITY: Soluble in methanol, 100% ethanol, ethyl acetate or acetonitrile; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
MELTINGPOINT:

 

Product Description
Specific and irreversible inhibitor of HMG-CoA synthase in vitro and in vivo. Inhibits mevalonate biosynthesis. Shows antimicrobial and antifungal activity.
Product Specific Literature References
Antibiotic 1233A: a fungal -lactone: D.C. Aldridge, et al.; J. Chem. Soc. 23, 3888 (1971) Abstract
Potent inhibitory effect of antibiotic 1233A on cholesterol biosynthesis which specifically blocks 3-hydroxy-3-methylglutaryl coenzyme A synthase: S. Omura, et al.; J. Antibiot. 40, 1356 (1987) Abstract
F-244 specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A synthase: H. Tomoda, et al.; Biochim. Biophys. Acta 922, 351 (1987) Abstract
F-244 (1233A), a specific inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A synthase: taxonomy of producing strain, fermentation, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 41, 247 (1988) Abstract
Method of search for microbial inhibitors of mevalonate biosynthesis using animal cells: H. Kumagai, et al.; J. Antibiot. 43, 397 (1990) Abstract
Biosynthesis of antibiotic 1233A (F-244) and preparation of [14C]1233A: H. Kumagai, et al.; J. Antibiot. 45, 563 (1992) Abstract
Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme A synthase: T. Sunazuka, et al.; J. Antibiot. 45, 1139 (1992) Abstract
Inhibition of hepatic cholesterol biosynthesis by a 3-hydroxy-3-methylglutaryl coenzyme A synthase inhibitor, 1233A, in mice: H. Nagashima, et al.; Life Sci. 52, 1595 (1993) Abstract
Specific binding of beta-lactone 1233A to 3-hydroxy-3-methylglutaryl-coenzyme A synthase: H. Tomoda, et al.; J. Antibiot. 46, 872 (1993) Abstract
Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase inhibitors: 2-oxetanones with a side chain mimicking the folded structure of 1233A: H. Hashizume, et al.; Chem. Pharm. Bull. 42, 512 (1994) Abstract
Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-oxetanones with a meta-substituent on the benzene ring in the side chain: H. Hashizume, et al.; Chem. Pharm. Bull. 42, 1272 (1994) Abstract
Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 2-oxetanones with a side chain mimicking the extended structure of 1233A: H. Hashizume, et al.; Chem. Pharm. Bull. 42, 2097 (1994) Abstract
Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase: H. Tomoda, et al.; Biochim. Biophys. Acta 1636, 22 (2004) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-350-279 Revised 02-Jun-08
Isoxanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-279-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004) Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005) Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006) Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006)
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Flavanones • Estrogen & Estrogen Receptors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - Other Signal Transduction Pathway Modulators • Lipid Metabolism Other Products
 
 
ALX-210-431 Revised 14-Mar-06
Polyclonal Antibody to SCD1 (mouse)
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SYNONYMS anti-Stearoyl-CoA Desaturase 1 (mouse) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Adipokines Other Products
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ALX-210-431-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Synthetic peptide corresponding to aa 21-33 (A21PPSGNEREKVKT33) of mouse SCD1 (stearoyl-CoA desaturase 1).
SPECIFICITY: Recognizes mouse SCD1. Detects a band of ~41kDa by Western Blot.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies • Lipid Metabolism Other Products
 
 
ALX-380-285 Revised 16-Sep-08
Triacsin C
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SYNONYMS 2,4,7-Undecatrienal nitrosohydrazone
WS1228A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Apoptosis Inducers & Inhibitors
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ALX-380-285-MC05   0.5 mg 190.00 USD Add To Cart
ALX-380-285-M001   1 mg 350.00 USD Add To Cart
Product Specification
FORMULA: C11H17N3O
MW: 207.3
CAS NUMBER: 76896-80-5