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Natural Products / Antibiotics
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ALX-350-301 Revised 14-May-07
Oxaspirodion
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-301-MC05   0.5 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C13H14O5
MW: 250.3
SOURCE/HOST: Isolated from Chaetomium subspirale.
APPEARANCE: Orange to brown oil.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Mixture of 4 non-separable isomers. Inhibits TNF-α expression (IC50=2.5µg/ml). Exhibits no antibacterial and antifungal activities up to 100µg/disk in the standard disk assay. Weak cytotoxic properties against tumor cells. Inhibition of the TNF-α promoter activity is caused by an inhibition of the phosphorylation of the ERK1/2 kinases. In addition, oxaspirodion inhibits the activation of the transcription factor NF-κB, which is involved in the inducible expression of many proinflammatory genes.
Product Specific Literature References
Oxaspirodion, a new inhibitor of inducible TNF-alpha expression from the Ascomycete chaetomium subspirale. Production, isolation and structure elucidation: J. Rether, et al.; J. Antibiot. 57, 493 (2004) Abstract
Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale: J. Rether, et al.; Biol. Chem. 385, 829 (2004) Abstract
Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • NF-kB Pathway Inhibitors
 
 
ALX-445-020 Revised 10-Jun-03
20-Oxo-20-deoxyphorbol 12,13-dibutyrate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Phorbols / Phorbol Esters
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ALX-445-020-M001   1 mg 75.00 USD Add To Cart
ALX-445-020-M005   5 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C28H38O8
MW: 502.6
CAS NUMBER: 100930-03-8
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT. POTENTIAL TUMOR PROMOTER.

Product Description
Used to prepare [3H]-PDBu.
Product Specific Literature References
Active principles of croton oil. X. Preparation of tritium labeled croton oil factor A1 and other tritium labeled phorbol derivatives: G. Kreibich & E. Hecker; Z. Krebsforsch. 74, 448 (1970) Abstract
 
 
ALX-380-210 Revised 08-Apr-08
7-Oxostaurosporine
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SYNONYMS Antibiotic BMY 41950
Antibiotic RK 1409
LCM76-L
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Protein Kinase Inhibitors
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ALX-380-210-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C28H24N4O4
MW: 480.5
CAS NUMBER: 141196-69-2
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5345.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, methanol or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Antibiotic. Potent inhibitor of protein kinase C (PKC). Inhibits the cell cycle at the G2 stage.
Product Specific Literature References
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity: H. Osada, et al.; J. Antibiot. 45, 189 (1992) Abstract
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure: H. Koshino, et al.; J. Antibiot. 45, 195 (1992) Abstract
Further Categories Containing This Product:
PKC Inhibitors • Cell Cycle Blockers & Inhibitors / Related Products • Staurosporine / Related Products • Antibiotics for Cell Cycle Research • Alkaloids
 
 
ALX-351-001 Revised 08-Apr-08
Paclitaxel
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SYNONYMS Taxol®
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-351-001-M001   1 mg 20.00 USD Add To Cart
ALX-351-001-M005   5 mg 50.00 USD Add To Cart
ALX-351-001-M025   25 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C47H51NO14
MW: 853.9
CAS NUMBER: 33069-62-4
MERCK INDEX: 14: 6982
RTECS: DA8340700
SOURCE/HOST: Isolated from Taxus brevifolia.
PURITY: ≥98%
APPEARANCE: Off-white crystalline powder.
SOLUBILITY: Soluble in acetonitrile, DMSO or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
HAZARD: MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.
IDENTITY: Determined by IR.

Product Description

Antitumor agent. Binds to tubulin. Promotes assembly and inhibits disassembly of microtubules. Blocks the cell cycle at the mitotic phase and induces apoptosis. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CDKs) and the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) are involved in paclitaxel-induced apoptosis.
Product Specific Literature References
CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells: Y.D. Yoo, et al.; Clin Cancer Res 4, 3063 (1998) Abstract
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) Abstract
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang, et al.; Cancer 88, 2619 (2000) Abstract
Disruption of Cell Adhesion and Caspase-Mediated Proteolysis of beta- and gamma-Catenins and APC Protein in Paclitaxel-Induced Apoptosis:: Y.H. Ling, et al.; Mol. Pharmaco. 59, 593 (2001) Abstract; Full Text
Taxol: biosynthesis, molecular genetics, and biotechnological applications: S. Jennewein and R. Croteau; Appl. Microbiol. Biotechnol. 57, 13 (2001) Abstract
Chemistry and chemical biology of taxane anticancer agents: M.L. Miller and I. Ojima; Chem. Rec. 1, 195 (2001) Abstract
Paclitaxel and its formulations: A.K. Singla, et al.; Int. J. Pharm. 235, 179 (2002) Abstract
Paclitaxel in cancer therapy: T.M. Mekhail and M. Markman; Expert. Opin. Pharmacother. 3, 755 (2002) Abstract
Taxol reactions: K.S. Price and M.C. Castells; Allergy Asthma Proc. 23, 205 (2002) Abstract
The chemistry of taxol and related taxoids: D.G. Kingston, et al.; Fortschr. Chem. Org. Naturst. 84, 53 (2002) Abstract
Overcoming multidrug resistance in taxane chemotherapy: R. Geney, et al.; Clin. Chem. Lab. Med. 40, 918 (2002) Abstract
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action: M. Abal, et al.; Curr. Cancer Drug Targets 300, 193 (2003) Abstract
Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer: D. Simpson & G.L. Plosker; Drugs 64, 1839 (2004), Review Abstract
Paclitaxel for AIDS-associated Kaposi’s sarcoma: T. Dhillon, et al.; Expert Rev. Anticancer Ther. 5, 215 (2005), Review Abstract
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo: P. Wagner, et al.; Cell Cycle 4, 1149 (2005), Review Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators • Alkaloids • TLR Agonists Other Products
 
 
ALX-350-109 Revised 29-Nov-07
Panepoxydone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-109-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C11H14O4
MW: 210.2
SOURCE/HOST: Isolated from Lentinus crinitus.
PURITY: >95% (HPLC)
FORMULATION: Yellow oil
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light. Keep cool and dry.
HAZARD: TOXIC.

Product Description
Antibiotic. Inhibitor of NF-κB activation by preventing the phosphorylation of IκB protein and thereby interrupts the signalling pathway. Strongly inhibits the expression of several NF-κB dependent pro-inflammatory genes.
Product Specific Literature References
Inhibition of NF-kappa B activation by panepoxydone: G. Erkel, et al.; BBRC 226, 214 (1996) Abstract
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways: H. Kleinert, et al.; Br. J. Pharmacol. 125, 193 (1998) Abstract
Naturally occurring and synthetic inhibitors of NF-kappaB functions: K. Umezawa, et al.; Anticancer Drug Des. 15, 239 (2000) Abstract
Inhibitors of NF-kappaB signaling: design and synthesis of a biotinylated isopanepoxydone affinity reagent: J.B. Shotwell, et al.; Bioorg. Med. Chem. Lett. 12, 3463 (2002) Abstract
Molecular design and biological activities of NF-kappaB inhibitors: K. Umezawa & C. Chaicharoenpong; Mol. Cells 14, 163 (2002) Abstract
Influence of the fungal NF-kappaB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells: G. Erkel, et al.; Int. Immunopharmacol. 7, 612 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Natural Products with Antibiotic Activity • NF-kB Pathway Inhibitors
 
 
ALX-270-110 Revised 20-Jun-08
Papaverine . hydrochloride
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SYNONYMS 1-[(3',4'-Dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline . HCl
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-110-G005   5 g 22.00 USD Add To Cart
Product Specification
FORMULA: C20H21NO4 . HCl
MW: 339.4 . 36.5
CAS NUMBER: 61-25-6
MERCK INDEX: 14: 7019
RTECS: NW8575000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description

Originally isolated from opium. Alkaloid with smooth muscle relaxing activity. Inhibits phosphodiesterases.
Product Specific Literature References
Papaverine-induced inhibition of phosphodiesterase activity in various mammalian tissues: G. Poch & W.R. Kukovetz; Life Sci. I 10, 133 (1971) Abstract
Effects of papaverine on smooth muscle and their mechanisms: M. Ferrari; Pharmacol. res. Commun. 6, 97 (1974) Abstract
The effect of papaverine on ion channels in rat basilar smooth muscle cells: D. Han, et al.; Neurol. Res. 29, 544 (2007) Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products • Alkaloids
 
 
ALX-350-348 Revised 22-Feb-08
Papuamine
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SYNONYMS (-)-Papuamine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antifungal Agents
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ALX-350-348-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C25H40N2
MW: 368.6
CAS NUMBER: 112455-84-2
SOURCE/HOST: Isolated from sponge Haliclona sp.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow amorphous solid.
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol; poorly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description

C2-symmetrical pentacyclic alkaloid with antifungal and antimycobacterial activity.
Product Specific Literature References
Papuamine, an antifungal pentacyclic alkaloid from a marine sponge Haliclona sp.: B.J. Baker, et al.; JACS 110, 965 (1988)
Total Synthesis of (+)-Papuamine: An Antifungal Pentacyclic Alkaloid from a Marine Sponge, Haliclona sp.: A.G.M. Barrett, et al.; J. Org. Chem. 61, 685 (1996) Abstract
Total Syntheses of (-)-Papuamine and (-)-Haliclonadiamine: T.S McDermott, et al.; J. Org. Chem. 61, 700 (1996) Abstract
Towards a Biomimetic Synthesis of the Marine Alkaloids Papuamine and Haliclonadiamine: Model Studies: R.M. Adlington, et al. ; Tetrahedron 56, 623 (2000)
A Mycobacterium marinum zone of inhibition assay as a method for screening potential antimycobacterial compounds from marine extracts: L.P. Barker, et al.; Planta Med. 73, 559 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Other Anti-infective Agents • Marine Natural Products
 
 
ALX-380-215 Revised 08-Apr-08
Paraherquamide A
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SYNONYMS VM 29919
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-215-M001   1 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C28H35N3O5
MW: 493.6
CAS NUMBER: 77392-58-6
RTECS: RV0545000
SOURCE/HOST: Isolated from Penicillium simplicissimum MST-FP116A.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic. Selective and competitive cholinergic antagonist that distinguishes subtypes of cholinergic receptors. Anti-helmintic.
Product Specific Literature References
Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity: J.G. Ondeyka, et al.; J. Antibiot. (Tokyo) 43, 1375 (1990) Abstract
Acute toxicity of paraherquamide and its potential as an anthelmintic: W.L. Shoop, et al.; Am. J. Vet. Res. 53, 2032 (1992) Abstract
Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals: E.W. Zinser, et al.; J. Vet. Pharmacol. Ther. 25, 241 (2002) Abstract
Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle: A.P. Robertson, et al.; J. Pharmacol. Exp. Ther. 302, 853 (2002) Abstract; Full Text
Further Categories Containing This Product:
Helminth Infections / Related Products • Acetylcholine Receptors Other Products
 
 
ALX-350-258 Revised 08-Apr-08
Parthenolide
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SYNONYMS (1aR-[1aR*,4E,7aS*,-10aS*,-10bR*])-2,3-6,7,7a,8,10a,10b-Octahydro-1a,5-dimethyl-8-methyleneoxireno[9,10]cyclo deca[1,2-b]furan-9(1aH)-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-258-M005   5 mg 15.00 USD Add To Cart
ALX-350-258-M025   25 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C15H20O3
MW: 248.3
CAS NUMBER: 20554-84-1
MERCK INDEX: 14: 7048
RTECS: LY4220000
SOURCE/HOST: Isolated from feverfew leaves.
PURITY: ≥99% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO (100mg/ml), dichloromethane (50mg/ml) or 100% ethanol (20mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Sesquiterpene lactone. Anti-inflammatory compound. Specifically inhibits activation of NF-κB by preventing the degradation of IκBα and IκBβ. Inhibits activation of MAP kinase (MAPK/ERK) and generation of leukotriene B4 and thromboxane B2. Potent anticancer agent. Induces apoptosis in various cancer cell lines. Specifically inhibits histone deacetylase 1 (HDAC1) without affecting other class I/II HDACs. Inhibits tubulin carboxypeptidase (TCP) activity.
Product Specific Literature References
A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro: W.A. Groenewegen & S. Heptinstall; J. Pharm. Pharmacol. 42, 553 (1990) Abstract
Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta: R.W. Barsby, et al.; J. Pharm. Pharmacol. 44, 737 (1992) Abstract
Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components: H. Sumner, et al.; Biochem. Pharmacol. 43, 2313 (1992) Abstract
Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases: D. Hwang, et al.; BBRC 226, 810 (1996) Abstract
Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta: S.P. Hehner, et al.; J. Biol. Chem. 273, 1288 (1998) Abstract
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells: H.R. Wong & I.Y. Menendez; BBRC 262, 375 (1999) Abstract
The antiinflammatory sesquiterpene lactone parthenolide inhibits NF- kappa B by targeting the I kappa B kinase complex: S.P. Hehner, et al.; J. Immunol. 163, 5617 (1999) Abstract
Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappaB is enhanced by IkappaBalpha super-repressor and parthenolide: N.M. Patel, et al.; Oncogene 19, 4159 (2000) Abstract
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase: H. Nakshatri, et al.; Oncogene 23, 7330 (2004) Abstract
Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis: S. Zhang, et al.; Cancer Lett. 211, 175 (2004) Abstract
Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity: W. Wang, et al.; Apoptosis 11, 2225 (2006) Abstract
Parthenolide inhibits tubulin carboxypeptidase activity: X. Fonrose, et al.; Cancer Res. 67, 3371 (2007) Abstract
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated: Y.N. Gopal, et al.; Chem. Biol. 14, 813 (2007) Abstract
Further Categories Containing This Product:
MAPK Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • NF-kB Pathway Inhibitors • Natural Products - Apoptosis Inducers & Inhibitors • COX Inhibitors • Other Natural Products for Inflammation Research
 
 
ALX-270-111 Revised 31-Jul-08
Patulin