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ALX-350-106
Revised 29-Nov-07
Ampullosporin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
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ALX-350-106-M001
1 mg
50.00 USD
Product Specification
SEQUENCE:
Ac-Trp-Ala-Aib-Aib-Leu-Aib-Gln-Aib-Aib-Aib-Gln-Leu-Aib-Gln-Leucinol
FORMULA:
C
77
H
127
N
19
O
19
MW:
1623.0
SOURCE/HOST:
Antibiotic isolated from
Sepedonium ampullosporum
.
PURITY:
≥98% (HPLC)
SOLUBILITY:
Soluble in alcohols, chloroform or dichloromethane. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Peptaibol-type polypeptide. Induces pigment formation by the fungus
Phoma destructiva
, causes hypothermia in mice, displays neuroleptic activity in rats and forms instable pores in artificial bilayer membranes.
Product Specific Literature References
Ampullosporin, a new peptaibol-type antibiotic from
Sepedonium ampullosporum
HKI-0053 with neuroleptic activity in mice:
M. Ritzau, et al.; J. Antibiot.
50
, 722 (1997)
Abstract
Differences in ion permeability of an artificial bilayer membrane caused by ampullosporin and bergofungin, new 15-membered peptaibol-type antibiotics:
P. Grigoriev, et al.; Bioelectrochemistry
44
, 155 (1997)
Differences in ion-channel formation by ampullosporins B, C, D and semisynthetic desacetyltryptophanyl ampullosporin A:
P. Grigoriev, et al.; Bioelectrochemistry
57
, 119 (2002)
Abstract
Synthesis and biological evaluation of analogues of the peptaibol ampullosporin A:
H.H. Nguyen, et al.; J. Med. Chem.
45
, 2781 (2002)
Abstract
Crystal structure and conformational analysis of ampullosporin A:
M. Kronen, et al.; J. Pept. Sci.
9
, 729 (2003)
Abstract
Membrane association and activity of 15/16-membered peptide antibiotics: zervamicin IIB, ampullosporin A and antiamoebin I:
T.N. Kropacheva, et al.; Biochim. Biophys. Acta
1715
, 6 (2005)
Abstract
Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model:
H. Krugel, et al.; J. Neurochem.
97, Suppl. 1
, 74 (2006)
Abstract
Further Categories Containing This Product:
Alzheimer Research Other Products
•
Ion Channels & Transporters Other Products
•
Peptides
ALX-350-112
Revised 29-Nov-07
Anabasine . hydrochloride
SYNONYMS
3-(2-Piperidinyl)pyridine
2-(3-Pyridyl)piperidine
Neonicotine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
Ordering Information
Product Numbers:
Format:
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ALX-350-112-M025
25 mg
20.00 USD
ALX-350-112-M100
100 mg
60.00 USD
Product Specification
FORMULA:
C
10
H
14
N
2
. HCl
MW:
162.2 . 36.5
CAS NUMBER:
15251-47-5
MERCK INDEX:
14:
619
SOURCE/HOST:
Isolated from
Anabasis aphylla.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in alcohol or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Tobacco alkaloid. Potent nicotinic acetylcholine receptor agonist. Insecticide.
Product Specific Literature References
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro:
R.L. Barbieri, et al.; J. Clin. Invest.
77
, 1727 (1986)
Abstract
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy:
P. Jacob, 3rd, et al.; Cancer Epidemiol. Biomarkers Prev.
11
, 1668 (2002)
Abstract
Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia:
J. Mastropaolo, et al.; Behav. Brain Res.
153
, 419 (2004)
Abstract
Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry:
X. Xu, et al.; Clin. Chem.
50
, 2323 (2004)
Abstract
Anabasine toxicity from a topical folk remedy:
N.G. Murphy, et al.; Clin. Pediatr. (Phila)
45
, 669 (2006)
Abstract
Further Categories Containing This Product:
Alkaloids
•
Pesticides / Related Products
•
Acetylcholine Receptors (Nicotinic) / Related Products
ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
Epigenetics
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases / Related Products
Ordering Information
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ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.
Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC
50
~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid:
J.T. Sullivan, et al.; Planta Med.
44
, 175 (1982)
Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids:
R. Grazzini, et al.; BBRC
176
, 775 (1991)
Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus:
H. Muroi & I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
;
Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation:
Y. Sun, et al.; FEBS Lett.
580
, 4353 (2006)
Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
:
H. Muroi and I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition
:
R. Paramashivappa, et al.; J. Agric. Food Chem.
50
, 7709 (2002)
Abstract
Further Categories Containing This Product:
Prostaglandin Synthases / Related Products
•
Lipoxygenases / Related Products
•
Antibiotics Other Products
ALX-350-331
Revised 19-Oct-07
Angoroside C
SYNONYMS
Isoangoroside C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Anti-inflammatory Agents
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ALX-350-331-M001
1 mg
30.00 USD
ALX-350-331-M005
5 mg
120.00 USD
Product Specification
FORMULA:
C
36
H
48
O
19
MW:
784.8
CAS NUMBER:
115909-22-3
SOURCE/HOST:
Isolated from the root of
Scrophularia ningpoensis Hemsl
(Figwort).
PURITY:
≥98% (HPLC)
APPEARANCE:
White to pale yellow powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Potential anti-inflammatory compound. Inhibitor of prostaglandin E
2
release in mouse peritoneal macrophages
in vitro
. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and dGMP. Reveals some trypanocidal potential.
Product Specific Literature References
Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl:
Y.M. Li, et al.; Acta Pharmacol. Sin.
21
, 1125 (2000)
Abstract
Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity:
A.M. Diaz, et al.; Life Sci.
74
, 2515 (2004)
Abstract
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots:
D. Tasdemir, et al.; Phytochemistry
66
, 355 (2005)
Abstract
Further Categories Containing This Product:
Natural Products - Antioxidants
ALX-380-202
Revised 28-May-08
Anguinomycin A
SYNONYMS
5-Demethylleptomycin A
KR 2827A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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ALX-380-202-MC01
0.1 mg
460.00 USD
Product Specification
FORMULA:
C
31
H
44
O
6
MW:
512.7
CAS NUMBER:
111278-01-4
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5546.
PURITY:
≥95% (HPLC)
APPEARANCE:
Clear film.
SOLUBILITY:
Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antitumor antibiotic. Displays nanomolar cytotoxicity to murine P388 leukemia cells. Analog of leptomycin B (Prod. No.
ALX-380-100
), an inhibitor of nuclear protein export.
Product Specific Literature References
New antitumor antibiotics, anguinomycins A and B:
Y. Hayakawa, et al.; J. Antibiot. (Tokyo)
40
, 1349 (1987)
Abstract
Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells:
Y. Hayakawa, et al.; J. Antibiot. (Tokyo)
48
, 954 (1995)
Abstract
ALX-380-051
Revised 20-Jun-08
Anisomycin
SYNONYMS
2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
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ALX-380-051-M010
10 mg
35.00 USD
ALX-380-051-M050
50 mg
140.00 USD
ALX-380-051-M100
100 mg
250.00 USD
Product Specification
FORMULA:
C
14
H
19
NO
4
MW:
265.3
CAS NUMBER:
22862-76-6
MERCK INDEX:
14:
670
RTECS:
BZ9800000
SOURCE/HOST:
Isolated from
Streptomyces griseolus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in DMSO (25mg/ml), 100% ethanol, methanol or ethyl acetate (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
Antibiotic. Activator of p38 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFos and cJun, by acting as a potent signalling agonist. Induces apoptosis in the human monoblastoid cell line. Used in the eradication of bean mildew. Inhibits other pathogenic fungi in plants.
Product Specific Literature References
Anisomycin, a new anti-protozoan antibiotic:
B. A. Sobin & F. W. Tanner; J. Am. Chem. Soc.
76
, 4053 (1954)
DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis:
S.K. Kochi & R.J. Collier; Exp. Cell. Res.
208
, 296 (1993)
Abstract
The stress-activated protein kinase subfamily of c-Jun kinases:
J.M. Kyriakis, et al.; Nature
369
, 156 (1994)
Abstract
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun:
I. Sanchez, et al.; Nature
372
, 794 (1994)
Abstract
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction:
E. Kardalinou, et al.; Mol. Cell. Biol.
14
, 1066 (1994)
Abstract
Protein synthesis inhibitor phase shifts vasopressin rhythms in long- term suprachiasmatic cultures:
K. Shinohara & T. Oka; NeuroReport
5
, 2201 (1994)
Abstract
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction:
C.A. Hazzalin, et al.; Mol Cell Biol
18
, 1844 (1998)
Abstract
Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala:
P. Okulski, et al.; Neuroscience
114
, 1 (2002)
Abstract
Downregulation of Ski and SnoN co-repressors by anisomycin:
A. Vazquez-Macias, et al.; FEBS Lett.
579
, 3701 (2005)
Abstract
Anisomycin and the reconsolidation hypothesis:
J.W. Rudy, et al.; Learn. Mem.
13
, 1 (2006), Review
Abstract
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis:
I.A. Mawji, et al.; Cancer Res.
67
, 8307 (2007)
Abstract
Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade:
A. N. Kukushkin, et al.; J. Cell. Biochem.
103
, 1005 (2008)
Abstract
Further Categories Containing This Product:
MAPK Pathway Activators
•
JNK [SAPK1] / Related Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
ALX-380-203
Revised 27-Jun-08
Ansatrienin A
SYNONYMS
Mycotrienin I
T 23I
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
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ALX-380-203-M001
1 mg
170.00 USD
Product Specification
FORMULA:
C
36
H
48
N
2
O
8
MW:
636.8
CAS NUMBER:
82189-03-5
RTECS:
AY4553220
SOURCE/HOST:
Isolated from
Streptomyces collinus.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Antitumor antibiotic, closely related to the cytotrienins. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces:
C. Coronelli, et al.; J. Antibiot. (Tokyo)
20
, 329 (1967)
Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II:
M. Sugita, et al.; J. Antibiot. (Tokyo)
35
, 1460 (1982)
Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II:
M. Sugita, et al.; J. Antibiot. (Tokyo)
35
, 1467 (1982)
Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols:
M. Kuwano, et al.; Gann.
74
, 759 (1983)
Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption:
D. Feuerbach, et al.; J. Biol. Chem.
270
, 25949 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
ALX-380-204
Revised 17-Jun-08
Ansatrienin B
SYNONYMS
Mycotrienin II
T 23II
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
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ALX-380-204-M001
1 mg
380.00 USD
Product Specification
FORMULA:
C
36
H
50
N
2
O
8
MW:
638.8
CAS NUMBER:
82189-04-6
RTECS:
AY4553430
SOURCE/HOST:
Isolated from
Streptomyces
sp. MST-AS5998.
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antitumor antibiotic, closely related to the cytotrienins. Displays potent anticancer activities. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.
Product Specific Literature References
Mycotrienin, a new polyene antibiotic isolated from Streptomyces:
C. Coronelli, et al.; J. Antibiot. (Tokyo)
20
, 329 (1967)
Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II:
M. Sugita, et al.; J. Antibiot. (Tokyo)
35
, 1460 (1982)
Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II:
M. Sugita, et al.; J. Antibiot. (Tokyo)
35
, 1467 (1982)
Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols:
M. Kuwano, et al.; Gann.
74
, 759 (1983)
Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption:
D. Feuerbach, et al.; J. Biol. Chem.
270
, 25949 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
Bone Metabolism Other Products
ALX-380-075
Revised 03-Apr-08
Antimycin A
SYNONYMS
Antipiricullin
Virosin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
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Format:
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Unit Price:
Quantity:
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ALX-380-075-M005
5 mg
20.00 USD
ALX-380-075-M010
10 mg
33.00 USD
Product Specification
CAS NUMBER:
1397-94-0
MERCK INDEX:
14:
714 (A1) & 715 (A3)
RTECS:
CD0350000
SOURCE/HOST:
Isolated from
Streptomyces sp
. Mixture of antimycin A's.
APPEARANCE:
White to faint yellow powder.
SOLUBILITY:
Soluble in 100% ethanol (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
