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DNA Fragmentation, Damage & Repair
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ALX-210-304 Revised 27-Dec-06
Polyclonal Antibody to XRCC1 (human)
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SYNONYMS anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY XRCC Proteins / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-304-R050   50 µl 235.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains 0.1% sodium azide.
IMMUNOGEN: Recombinant human XRCC1 (X-ray repair cross-complementing group 1).
SPECIFICITY: Recognizes human XRCC1.
APPLICATION: ELISA
Immunocytochemistry
Immunoprecipitation
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1: V. Schreiber, et al.; J. Biol. Chem. 277, 23028 (2002) Abstract; Full Text
General Information
XRCC1 (X-ray repair cross-complementing 1) exerts multiple functions in repairing base damage and frank single strand breaks. These functions include stabilizing DNA ligase 3, bridging the steps in base excision repair (BER) through protein interactions (via its BRCT motif), directly detecting breaks produced by chemical or enzymatic action, coordinating the binding and polymerase activity of DNA polymerase β, promoting an S phase-specific mode of single strand break repair. XRCC1 is specifically associated with poly(ADP-ribose) polymerase (PARP) and negatively regulates its activity following DNA damage.
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Further Categories Containing This Product:
PARP Other Products • Polyclonal Antibodies
 
 
ALX-210-539 Revised 27-Oct-06
Polyclonal Antibody to XRCC1 (human)
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SYNONYMS anti-X-ray Repair Cross-complementing Group 1 (human) PAb
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY XRCC Proteins / Related Products
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ALX-210-539-R100   100 µl 250.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Antiserum containing 0.1% sodium azide.
IMMUNOGEN: Recombinant human XRCC1 (X-ray repair cross-complementing group 1) fused to a His-tag.
SPECIFICITY: Recognizes human XRCC1.
APPLICATION: Immunocytochemistry (1:1’000)
Immunoprecipitation (1:200)
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least one year when stored at +4°C.
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Product Specific Literature References
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage: M. Masson, et al.; Mol. Cell. Biol. 18, 3563 (1998) Abstract; Full Text
XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage: N. Levy, et al.; Nucl. Acids Res. 34, 32 (2006) Full Text
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Further Categories Containing This Product:
PARP Other Products • Polyclonal Antibodies
 
 
ALX-210-481 Revised 13-Feb-08
Polyclonal Antibody to Ribosomal Protein S3 (human)
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SYNONYMS anti-RPS3 (human) PAb
anti-40S Ribosomal Protein S3 (human) PAb
anti-IMR-90 Ribosomal Protein S3 (human) PAb
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins / Related Products
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ALX-210-481-C100   100 µg 410.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant human ribosomal protein S3.
SPECIFICITY: Recognizes human ribosomal protein S3.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Immunoprecipitation (1:500-1:5’000)
Western Blot (1:500-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1-2 weeks when stored at +4°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 17, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • DNA Endonucleases / Related Products • NF-kB Pathway Other Products • MAPK Pathway Other Products • Polyclonal Antibodies
 
 
ALX-201-296 Revised 15-Oct-08 New product
Replication Protein A (human) (recombinant)
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SYNONYMS RP-A (human) (recombinant)
Replication Factor A (human) (recombinant)
RF-A (human) (recombinant)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY DNA Repair Other Products
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ALX-201-296-C005   5 µg 260.00 USD Add To Cart
Product Specification
MW: ~118kDa (heterotrimer with subunits of 70, 32/34 and 14kDa)
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 0.16mg/ml
PURITY: ≥98% (SDS-PAGE).
FORMULATION: Liquid. In 20mM TRIS, pH 8.0, containing 10% (v/v) glycerol, 2mM EDTA and 1mM DTT.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for more then 2 year when stored at  -80°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Recombinant replication protein A: expression, complex formation, and functional characterization: L.A. Henricksen, et al.; J. Biol. Chem. 269, 11121 (1994) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot links
P27694: RFA1 (human)
P15927: RFA2 (human)
P35244: RFA3 (human)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • DNA Replication Other Products
 
 
ALX-201-410 Revised 13-Feb-08
Ribosomal Protein S3 (human) (recombinant)
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PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins / Related Products
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ALX-201-410-C010   10 µg 330.00 USD Add To Cart
ALX-201-410-C050   50 µg 740.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. The mature peptide of human ribosomal protein S3 (aa 1-243) is fused at the N-terminus to a tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 25mM TRIS-HCl, pH 8.5, containing 1mM DTT.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 174, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P23396: Ribosomal Protein S3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
MAPK Pathway Other Products • Co-Chaperones & HSP-interacting Proteins / Related Products • DNA Endonucleases / Related Products • NF-kB Pathway Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-408 Revised 27-Mar-08
Ribosomal Protein S3 (human) (recombinant) (His)
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SYNONYMS RPS3 (human) (recombinant) (His)
40S Ribosomal Protein S3
IMR-90 Ribosomal Protein S3
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Ribosomal Proteins / Related Products
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ALX-201-408-C010   10 µg 330.00 USD Add To Cart
ALX-201-408-C050   50 µg 740.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature peptide of human ribosomal protein S3 (aa 1-243) is fused at the C-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 25mM TRIS-HCl, pH 8.5, containing 1mM DTT.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Interaction of Hsp90 with ribosomal proteins protects from ubiquitination and proteasome-dependent degradation: T.S. Kim, et al.; Mol. Biol. Cell 17, 824 (2006) Abstract; Full Text
Reduction of invasion in human fibrosarcoma cells by ribosomal protein S3 in conjunction with Nm23-H1 and ERK: S.H. Kim & J. Kim; Biochim. Biophys. Acta 1763, 823 (2006) Abstract
Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation: F. Wan, et al.; Cell 131, 927 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P23396: Ribosomal Protein S3 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • DNA Endonucleases / Related Products • MAPK Pathway Other Products • Recombinant Proteins / Fusion Proteins • NF-kB Pathway Other Products
 
 
ALX-400-039 Revised 01-Apr-08
Semustine
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SYNONYMS Me-CCNU
N-[2-Chloroethyl]-N'-[4-methyl-cyclohexyl]-N-nitrosourea
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (DNA Interaction & Gene Regulation)
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ALX-400-039-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H18CIN3O2
MW: 247.7
CAS NUMBER: 13909-09-6
RTECS: YS5000000
PURITY:

≥98% (TLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in methanol (50mg/ml), 100% ethanol, lipids or nonpolar organic solvents; slightly soluble in water.
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Methylated derivative of carmustine with antineoplastic activity. Alkylating agent that forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission and DNA-DNA cross-linking which may result in cytotoxicity.
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Further Categories Containing This Product:
DNA Damage & Repair Other Products
 
 
ALX-270-365 Revised 01-Jul-08
TIQ-A
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SYNONYMS Thieno[2,3-c]isoquinolin-5-one
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PARP Inhibitors
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ALX-270-365-M001   1 mg 45.00 USD Add To Cart
ALX-270-365-M005   5 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C11H7NOS
MW: 201.2
PURITY: ≥98%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC50=450nM). Neuroprotectant.
Product Specific Literature References
Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia: A. Chiarugi, et al.; J. Pharmacol. Exp. Ther. 305, 943 (2003) Abstract; Full Text
Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors: R. Pellicciari, et al.; Farmaco 58, 851 (2003) Abstract
Further Categories Containing This Product:
DNA Repair Other Products
 
 
ALX-380-068 Revised 09-Apr-08
Trichostatin A
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SYNONYMS TSA
[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-068-M001   1 mg 115.00 USD Add To Cart
ALX-380-068-M005   5 mg 385.00 USD Add To Cart
Product Specification
FORMULA: C17H22N2O3
MW: 302.4
CAS NUMBER: 58880-19-6
MERCK INDEX: 14: 9649
SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
PURITY: ≥98% (HPLC)
APPEARANCE: Whitish film adhered to inside of vial.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, acetonitrile, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent, reversible inhibitor of histone deacetylase (HDAC). Mediates the activation of O6-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types. Induces cell growth arrest at both G1 and G2/M phases. May induce apoptosis in some cases. Induces acetylation of histone-3/4 and expression of p300.
Product Specific Literature References
A new antifungal antibiotic, trichostatin: N. Tsuji, et al.; J. Antibiot. 29, 1 (1976) Abstract
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A: M. Yoshida, et al.; J. Biol. Chem. 265, 17174 (1990) Abstract; Full Text
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines: Y. Hoshikawa, et al.; Exp. Cell Res. 214, 189 (1994) Abstract
Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells: M. Futamura, et al.; Oncogene 10, 1119 (1995) Abstract
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function: M. Yoshida, et al.; Bioessays 17, 423 (1995) Abstract
Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase: I. Takahashi, et al.; J. Antibiot. 49, 453 (1996) Abstract
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p: J. Taunton, et al.; Science 272, 408 (1996) Abstract
Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation: C. Van Lint, et al.; EMBO J. 15, 1112 (1996) Abstract
Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c- dependent pathway:: V. Medina, et al.; Cancer Res. 57, 3697 (1997) Abstract
A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells: S. Minucci, et al.; PNAS 94, 11295 (1997) Abstract; Full Text
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites: Y. Sowa, et al.; BBRC 241, 142 (1997) Abstract
Retinoblastoma protein recruits histone deacetylase to repress transcription: A. Brehm, et al.; Nature 391, 597 (1998) Abstract
Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells: S.G. Gray & T.J. Ekstrom; BBRC 245, 423 (1998) Abstract
Regulation of the human O6-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein- binding protein and p300: K.K. Bhakat & S. Mitra; J. Biol. Chem. 275, 34197 (2000) Abstract; Full Text
Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells: P.A. Marks, et al.; J. Natl. Cancer Inst. 92, 1210 (2000) Abstract
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo: D.M. Vigushin, et al.; Clin. Cancer Res. 7, 971 (2001) Abstract
Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow: S. Snykers, et al.; BMC Dev. Biol. 7, 24 (2007) Abstract
Trichostatin A induces myocardial differentiation of monkey ES cells: M. Hosseinkhani, et al.; BBRC 356, 386 (2007) Abstract