ALEXIS Biochemicals: Bumetanide

ALX-550-238

Revised 03-Feb-05

Bumetanide
SYNONYMS	Ro 10-6338 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-238-M500		500 mg	40.00 USD
ALX-550-238-G001		1 g	60.00 USD

Product Specification

FORMULA:	C₁₇H₂₀N₂O₅S
MW:	364.4
CAS NUMBER:	28395-03-1
MERCK INDEX:	14: 1484
PURITY:	≥99%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in ethanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	TOXIC.

Product Description

Specific inhibitor of Na⁺/K⁺/2Cl^- cotransport and is used clinically as a diuretic. Shows high affinity and specific binding to membranes of many cell types.

Product Specific Literature References

Characteristics and functions of Na-K-Cl cotransport in epithelial tissues: S.M. O'Grady, et al.; Am. J. Physiol. 253, C177 (1987) Abstract
Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells: J.D. Klein & W.C. O'Neill; J. Biol. Chem. 265, 22238 (1990) Abstract; Full Text
The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid: E.B. Pewitt, et al.; J. Biol. Chem. 265, 20747 (1990) Abstract; Full Text
Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly: R. Oberbauer, et al.; Clin. Pharmacol. Ther. 57, 42 (1995) Abstract

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