ALEXIS Biochemicals: CD137L, Soluble (mouse) (recombinant)

ALX-522-115

Revised 27-Mar-08

CD137L, Soluble (mouse) (recombinant)
SYNONYMS	4-1BBL, Soluble (mouse) (recombinant) TNFSF 9, Soluble (mouse) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	CD137 & CD137L / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-115-C010		10 µg	140.00 USD
ALX-522-115-3010	SuperPack	3x10 µg	260.00 USD

Product Specification

MW:	~40kDa
SOURCE/HOST:	Produced in HEK 293 cells. The extracellular domain of mouse CD137L (aa 104-309) is fused at the N-terminus to a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophillized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds to mouse CD137 (4-1BB).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

General Information

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56^lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P41274: CD137L (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

MANUFACTURER

Manufactured by Apotech Corporation.

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins • CD Proteins

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