ALEXIS Biochemicals: CDNF (human) (recombinant)

ALX-522-135

Revised 05-May-08

CDNF (human) (recombinant)
SYNONYMS	Conserved Dopamine Neurotrophic Factor (human) (recombinant) ARMEL (human) (recombinant) ARMET-like Protein 1 Precursor (human) (recombinant)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Neurotrophic Factors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-135-C010		10 µg	390.00 USD

Product Specification

MW:	~16kDa
SOURCE/HOST:	Produced in E. coli. Human CDNF (conserved dopamine neurotrophic factor) (aa 27-187).
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

General Information

CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Human CDNF encodes a 187 amino acid protein with predicted signal peptides. In mouse, it is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q49AH0: CDNF (human) FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo: P. Lindholm, et al.; Nature 448, 73 (2007) Abstract

ALX-210-960	Polyclonal Antibody to CDNF (mouse) (AT134)
ALX-522-133	CDNF (mouse) (recombinant)