ALEXIS Biochemicals: CDNF (mouse) (recombinant)

ALX-522-133

Revised 31-Mar-08

CDNF (mouse) (recombinant)
SYNONYMS	Conserved Dopamine Neurotrophic Factor (mouse) (recombinant) ARMEL (mouse) (recombinant) ARMET-like Protein 1 Precursor (mouse) (recombinant)
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Dopaminergics & Dopamine Receptors/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-133-C010		10 µg	390.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Mouse
MW:	~16kDa
SOURCE/HOST:	Produced in E. coli. Untagged mouse CDNF (aa 27-187).
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

CDNF (conserved dopamine neurotrophic factor) is a new neurotrophic factor (like GDNF) for dopaminergic neurons. Mouse CDNF encodes a 187 amino acid protein with predicted signal peptides. It is expressed in adult brain, heart, skeletal muscle and testis. CDNF has beneficial effects on mature dopaminergic neurons in a murine model of Parkinson’s disease.

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q8CC36: CDNF (mouse)

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo.: P. Lindholm, et al.; Nature 448, 73 (2007) Abstract

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