ALEXIS Biochemicals: CMH . hydrochloride

ALX-430-117

Revised 16-May-08

CMH . hydrochloride
SYNONYMS	1-Hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-117-M010		10 mg	65.00 USD
ALX-430-117-M050		50 mg	195.00 USD
ALX-430-117-M250		250 mg	450.00 USD

Product Specification

FORMULA:	C₁₀H₁₉NO₃ . HCl
MW:	201.3 . 36.5
PURITY:	≥99% (EPR)
APPEARANCE:	White to off-white crystalline powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Analog of CPH (Prod. No. ALX-430-078) with higher cell permeability and 3-fold better reactivity with superoxide. Has been used to study intracellular production of superoxide radicals in plasma, endothelial cells and isolated hearts.

Product Specific Literature References

Detection of superoxide with new cyclic hydroxylamine CMH in plasma, cells and isolated heart: B. Fink & S. Dikalov; Free Radical Biol. Med. 33, S366 (2002)
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion: J. Hwang, et al.; J. Biol. Chem. 278, 47291 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases: S.C. Dudley, Jr., et al.; Circulation 112, 1266 (2005) Abstract
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice: A. Dikalova, et al.; Circulation 112, 2668 (2005) Abstract
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension 49, 717 (2007) Abstract
Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay: S.I. Dikalov, et al.; Biochem. Pharmacol. 73, 972 (2007) Abstract; Full Text