ALEXIS Biochemicals: COX-1 (sheep)

ALX-202-030

Revised 26-May-08

COX-1 (sheep)
SYNONYMS	Cyclooxygenase 1 (sheep) Prostaglandin H Synthase 1 (sheep)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	COX

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-202-030-UT50		5 KU	259.00 USD

Product Specification

MW:	~70kDa.
EC:	1.14.99.1
SOURCE/HOST:	Isolated from sheep seminal vesicles.
CONCENTRATION:
PURITY:	≥95%
FORMULATION:	Liquid. In 80mM TRIS/HCl, pH 8.0, containing 0.1% Tween 20 and 300µM DDC.
ACTIVITY:	~20'000U/ml.
SPECIFIC ACTIVITY:	≥45,000U/mg protein. One unit is defined as the amount of enzyme that consumes 1nmol oxygen per min. at 37°C in 0.1M TRIS/HCl, pH 8.0, containing 100µM arachidonate, 5mM EDTA, 2mM phenol and 1µM hematin.
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Enzyme is extremely unstable in the absence of preservative and should be used within 1 hour.

Product Specific Literature References

Prostaglandin H synthase: L.J. Marnett & K.R. Maddipati; 'Peroxidases in Biology, vol 1' (J. Everse, et al. eds.), CRC Press, Inc., Boca Raton 293 (1991)
Prostaglandin endoperoxide synthase: structure and catalysis: W.L. Smith & L.J. Marnett; Biochim. Biophys. Acta 1083, 1 (1991) Abstract
Prostaglandin endoperoxide synthase: regulation of enzyme expression: D.L. DeWitt; Biochim. Biophys. Acta 1083, 121 (1991) Abstract
Mitogen-Inducible Prostaglandin G/H Synthase: A New Target for Nonsteroidal Antiinflammatory Drugs: W. Xie, et al.; Drug Development Research 25, 249 (1992)

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P05979: COX-1 (sheep) (precursor)
AfCS Signalling Gateway link A000738: COX-1 (mouse)

Further Categories Containing This Product:

Enzymes • Natural Proteins

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