ALEXIS Biochemicals: Cafestol

ALX-350-220

Revised 05-May-08

Cafestol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-220-M050		50 mg	160.00 USD

Product Specification

FORMULA:	C₂₀H₂₈O₃
MW:	316.4
CAS NUMBER:	469-83-0
MERCK INDEX:	14: 1634
SOURCE/HOST:	Isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Inducer of glutathione S-transferases. Has chemoprotective activity, reducing the genotoxicity of several carcinogens.

Product Specific Literature References

R.O. Bengis and R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
K.H. Slotta and K. Neisser; Ber. 71, 1991 (1938)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K.T. Lam, et al.; Cancer Res. 42, 1193 (1982)
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract

Further Categories Containing This Product:

Cytochrome P450 [CYP450] / Related Products • Glutathione S-Transferase • Active Substances from Fruit and Vegetables

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