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ALX-270-480 Revised 10-Mar-08 New product
Caffeic acid ethyl ester
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SYNONYMS CAEE
Ethyl caffeate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-480-M050   50 mg 20.00 USD Add To Cart
ALX-270-480-M250   250 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C11H12O4
MW: 208.2
CAS NUMBER: 66648-50-8
SOURCE/HOST: Synthetic.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least one year after receipt when stored at -20°C.
HANDLING: Protect from light and moisture.

Product Description
Shows anti-carcinogenic, anti-inflammatory and immunomodulatory properties. Suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production (IC50=5.5µg/ml). Potent and specific inhibitor of NF-κB and its downstream inflammatory mediators inducible nitric oxide synthase (iNOS; NOS II), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2). Prevents DNA single-strand breaks caused by H2O2.
Product Specific Literature References
Inhibitory effects of caffeic acid ethyl ester on H2O2-induced cytotoxicity and DNA single-strand breaks in Chinese hamster V79 cells: T. Nakayama, et al.; Biosci. Biotechnol. Biochem. 60, 316 (1996) Abstract
Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin: Y.M. Chiang, et al.; Br. J. Pharmacol. 146, 352 (2005) Abstract
Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines: M. Cardenas, et al.; Bioorg. Med. Chem. 14, 2966 (2006) Abstract
Drastic effect of several caffeic acid derivatives on the induction of heme oxygenase-1 expression revealed by quantitative real-time RT-PCR: K. Suzuki, et al.; Biofactors 28, 151 (2006) Abstract
Related Products
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Natural Products - Nitric Oxide Pathway Modulators • Prostaglandins Other Products • NF-kB Pathway Inhibitors • Natural Products - NF-kB Pathway Inhibitors • Natural Products - Immunomodulators
 
 
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