ALEXIS Biochemicals: Caffeic acid n-octyl ester

ALX-350-278

Revised 08-Apr-08

Caffeic acid n-octyl ester
SYNONYMS	n-Octylcaffeate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - NF-kB Pathway Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-278-M005		5 mg	25.00 USD
ALX-350-278-M025		25 mg	100.00 USD

Product Specification

FORMULA:	C₁₇H₂₄O₄
MW:	292.2
PURITY:	≥99%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

More potent analog than CAPE (Prod. No. ALX-270-244). Suppressor of inducible nitric oxide synthase (iNOS; NOS II). Induces apoptosis.

Product Specific Literature References

Mechanism of toxicity of esters of caffeic and dihydrocaffeic acids: B. Etzenhouser, et al.; Bioorg. Med. Chem. 9, 199 (2001) Abstract
A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma-induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells: G. Hsiao, et al.; Biochem. Pharmacol. 65, 1383 (2003) Abstract
Caffeic acid derivatives: in vitro and in vivo anti-inflammatory properties: F.M. da Cunha, et al.; Free Radic. Res. 38, 1241 (2004) Abstract
Octylcaffeate induced apoptosis in human leukemia U937 cells: M. Ujibe, et al.; Biol. Pharm. Bull. 28, 2338 (2005) Abstract

General Information

Octylcaffeate significantly ameliorates circulatory failure of endotoxemia by suppression of iNOS (NOS II) expression through inactivation of mitogen-activated protein kinases.

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • NF-kB Pathway Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Immunomodulators • Natural Products - Anti-inflammatory Agents

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