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ALX-610-026 Revised 03-Oct-08
Calcein AM
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SYNONYMS 3',6'-Di(O-acetyl-2',7'-bis[N,N-bis(carboxymethyl)-aminomethyl]fluorescein tetraacetoxymethyl ester
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-610-026-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C46H46N2O23
MW: 994.9
CAS NUMBER: 148504-34-1
PURITY: ≥95% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Packaged under inert gas.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Cell permeable derivative of calcein (Prod. No. ALX-610-025). When it permeates into the cytoplasm, it is hydrolyzed by esterases into the parent calcein which remains inside the cell. Has been used in a functional assay to measure P-glycoprotein (Pgp) and multidrug resistance protein (MRP) activities.
Product Specific Literature References
Kinetic analysis of calcein and calcein-acetoxymethylester efflux mediated by the multidrug resistance protein and P-glycoprotein: M. Essodaigui, et al.; Biochemistry 37, 2243 (1998) Abstract
Pgp and MRP activities using calcein-AM are prognostic factors in adult acute myeloid leukemia patients: O. Legrand, et al.; Blood 91, 4480 (1998) Abstract; Full Text
Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia: O. Legrand, et al.; Blood 94, 1046 (1999) Abstract; Full Text
Both Pgp and MRP1 activities using calcein-AM contribute to drug resistance in AML: O. Legrand, et al.; Adv. Exp. Med. Biol. 457, 161 (1999) Abstract
Further Categories Containing This Product:
P-glycoprotein [Pgp] / Related Products • MDR-associated Proteins [MRPs] / Related Products • Calcium Indicators / Probes
 
 
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