ALEXIS Biochemicals: Calpain Inhibitor I

ALX-260-037

Revised 30-May-07

Calpain Inhibitor I
SYNONYMS	Ac-LL-Norleucinal Ac-Leu-Leu-Nle-CHO
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calpains/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-037-M010		10 mg	80.00 USD
ALX-260-037-M050		50 mg	310.00 USD

Product Specification

FORMULA:	C₂₀H₃₇N₃O₄
MW:	383.5
CAS NUMBER:	110044-82-1
SOURCE/HOST:	Synthetic.
PURITY:	≥96% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and moisture.

Product Description

Inhibits calpain I (K_i=190nM), calpain II (K_i=220nM), cathepsin B (K_i=150nM) and cathepsin L (K_i=0.5nM). Inhibits neutral cysteine proteases and the proteasome. Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex.

Product Specific Literature References

Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene: J.M. Griscavage, et al.; BBRC 215, 721 (1995) Abstract

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