ALEXIS Biochemicals: Calpeptin

ALX-260-014

Revised 19-Aug-08

Calpeptin
SYNONYMS	Z-Leu-norleucinal
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calpains/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-014-M005		5 mg	85.00 USD
ALX-260-014-M010		10 mg	160.00 USD

Product Specification

FORMULA:	C₂₀H₃₀N₂O₄
MW:	362.5
CAS NUMBER:	117591-20-5
PURITY:	≥94% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	5mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 2 months when stored at -20°C.
HANDLING:	Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light and moisture.

Product Description

Membrane permeable inhibitor of calpain I and II and cathepsin L. Promotes neurite elongation in differentiating PC12 cells. Prevents Ca²⁺-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin (Prod. No. ALX-450-006) or thrombin.

Product Specific Literature References

Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins: T. Sasaki, et al.; J. Enz. Inhib. 3, 195 (1990) Abstract
Cell-penetrating inhibitors of calpain: S. Mehdi; TIBS 16, 150 (1991) Abstract
Specificity of calcium-activated neutral proteinase (CANP) inhibitors for human mu CANP and mCANP: K. Saito and R.A. Nixon; Neurochem. Res. 18, 231 (1993) Abstract
Calpeptin, a calpain inhibitor, promotes neurite elongation in differentiating PC12 cells: M. Pinter, et al.; Neurosci. Lett. 170, 91 (1994) Abstract

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