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Multidrug Resistance [MDR]
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ALX-380-078 Revised 07-Apr-08
Josamycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics for Cancer Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-078-M100   100 mg 30.00 USD Add To Cart
Product Specification
FORMULA: C42H69NO15
MW: 828.0
CAS NUMBER: 16846-24-5
MERCK INDEX: 14: 5267
RTECS: OH4725810
SOURCE/HOST: Isolated from Streptomyces narbonenensis, var. josamyceticus nov. var.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol, 100% ethanol, acetone, ethyl acetate, dioxane, or acidic water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C

Product Description
Macrolide antibiotic that may overcome anticancer drug resistance by inhibiting the binding of vinblastine (Prod. No. ALX-350-257) or cyclosporin A (Prod. No. ALX-380-002) to P-glycoprotein (Pgp).
Product Specific Literature References
A new antibiotic, josamyicn. I. Isolation and physico-chemical characteristics: T. Osono, et al.; J. Antibiot. (Tokyo) 20, 174 (1967) Abstract
Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo: L. Wang, et al.; Clin. Exp. Pharmacol. Physiol. 27, 587 (2000) Abstract
Kinetics of macrolide action: the josamycin and erythromycin cases: M. Lovmar, et al.; J. Biol. Chem. 279, 53506 (2004) Abstract
Further Categories Containing This Product:
MDR Inhibitors
 
 
ALX-270-307 Revised 08-Nov-06
JS-2190
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SYNONYMS Boc-Glu(OBzl)-N,N’-dicyclohexylurea
PRODUCT LINE Cancer
PRODUCT CATEGORY MDR Inhibitors
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ALX-270-307-M005   5 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C30H45N3O6
MW: 543.7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in chloroform (>10%); also soluble in 100% ethanol or ethanol:water 8:1 (mild heating up to 40°C).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

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Product Description
Inhibitor of P-glycoprotein (Pgp) and MRP1. Results obtained with the calcein assay protocol [1] indicate that JS-2190 is efficiently taken up by living cells.
General Literature References
[1] Calcein accumulation as a fluorometric functional assay of the multidrug transporter: Z. Hollo, et al.; Biochim. Biophys. Acta 1191, 384 (1994) Abstract
 
 
ALX-350-223 Revised 07-Apr-08
Kahweol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-223-M010   10 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C20H26O3
MW: 314.2
CAS NUMBER: 6894-43-5
SOURCE/HOST: Natural product isolated from the unsaponifiable fraction of petroleum ether extract of coffee beans.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in ethyl acetate, acetone or DMSO; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Induces glutathione S-transferase. Has anti-cancer, chemoprotective, anti-inflammatory and anti-atherosclerotic properties.
Product Specific Literature References
R.O. Bengis & R.J. Anderson; J. Biol. Chem. 47, 99 (1932)
Isolation and identification of kahweol palmitate and cafestol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse: L.K. Lam, et al.; Cancer Res. 42, 1193 (1982) Abstract
Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice: L.K. Lam, et al.; J. Med. Chem. 30, 1399 (1987) Abstract
Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol: B. Schilter, et al.; Carcinogenesis 17, 2377 (1996) Abstract
Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat: W.W. Huber, et al.; Mutat. Res. 376, 115 (1997) Abstract
The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism: C. Cavin, et al.; Carcinogenesis 19, 1369 (1998) Abstract
Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity: C. Cavin, et al.; Food Chem. Toxicol. 40, 1155 (2002) Abstract
The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells: H.G. Kim, et al.; Toxicol. Appl. Pharmacol. 217, 332 (2006) Abstract
Further Categories Containing This Product:
Glutathione S-Transferase • Natural Products - Anti-inflammatory Agents • Antitumor Agents (Enzyme Activators & Inducers) • TNF-alpha & TNF Receptors Other Products • CD11a, CD18 [LFA-1] & CD54 [ICAM-1], CD102 [ICAM-2], CD50 [ICAM-3] / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-440-045 Revised 17-Jul-07
Methotrexate
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SYNONYMS (+)-Amethopterin
4-Amino-10-methylfolic acid
Methylaminopterin
MTX
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Enzyme Inhibitors)
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ALX-440-045-M050   50 mg 25.00 USD Add To Cart
ALX-440-045-M100   100 mg 45.00 USD Add To Cart
ALX-440-045-M500   500 mg 135.00 USD Add To Cart
ALX-440-045-G001   1 g 240.00 USD Add To Cart
Product Specification
FORMULA: C20H22N8O5
MW: 454.5
CAS NUMBER: 59-05-2
MERCK INDEX: 14: 5985
PURITY: ≥98%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in alkaline solution; insoluble in water, 100% ethanol or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description
Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.
Product Specific Literature References
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest. 102, 322 (1998) Abstract
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res. 290, 240 (1998) Abstract
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc. 30, 2348 (1998) Abstract
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J. 342, 143 (1999) Abstract
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol. 27, 2551 (2000) Abstract
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology 47, 247 (2000) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Folic Acid & Folate Receptors / Related Products • DNA Replication Inhibitors • MDR Other Products
 
 
ALX-201-286 Revised 19-May-08 New product
Minor Vault p193 Protein (human) (recombinant) (His)
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SYNONYMS VPARP (human) (recombinant) (His)
PARP-4 (human) (recombinant) (His)
PRODUCT LINE Cancer
PRODUCT CATEGORY Minor Vault Protein p193 / Related Products
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ALX-201-286-C010   10 µg 270.00 USD Add To Cart
Product Specification
EC: 2.4.2.30
SOURCE/HOST: Produced in E. coli. Human minor vault p193 protein is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥98%
FORMULATION: Liquid. In PBS containing 50% glycerol.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
In silico characterization of the family of PARP-like poly(ADP-ribosyl)transferases (pARTs): H. Otto, et al.; BMC Genomics 6, 139 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9UKK3: PARP4 (human)
General Literature References
The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase: V.A. Kickhoefer, et al.; J. Cell Biol. 146, 917 (1999) Abstract; Full Text
Further Categories Containing This Product:
PARP Other Products • Recombinant Proteins / Fusion Proteins
 
 
ALX-380-097 Revised 23-Apr-08
Mithramycin A
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SYNONYMS Mithracin
Aureolic acid
Aurelic acid
Plicamycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-380-097-M001   1 mg 30.00 USD Add To Cart
ALX-380-097-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C52H76O24
MW: 1085.2
CAS NUMBER: 18378-89-7
MERCK INDEX: 14: 7536
RTECS: PZ2800000
SOURCE/HOST: Isolated from Streptomyces argillaceus.
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description

Antineoplastic and immunosuppressive antibiotic. Inhibits transcription and protein synthesis. Substrate of P-glycoprotein (Pgp) in multidrug resistant (MDR) cancer cells. Binds to DNA in native chromatin. DNA-binding fluorescent dye.
Product Specific Literature References
Aureolic acid group of anti-tumour antibiotics: Y.U. Berlin, et al.; Nature 218, 193 (1968) Abstract
Chromomycin A3, mithramycin, and olivomycin: antitumor antibiotics of related structure: M. Slavik & S.K. Carter; Adv. Pharmacol. Chemother. 12, 1 (1975) Abstract
Mithramycin blocks protein binding and function of the SV40 early promoter: R. Ray, et al.; J. Clin. Invest. 83, 2003 (1989) Abstract; Full Text
Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3: M.A. Mir, et al.; Bioorg. Med. Chem. 11, 2791 (2003) Abstract
Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression: S.Y. Ahn, et al.; Am. J. Pathol. 164, 1663 (2004) Abstract; Full Text
Mithramycin A activates Fas death pathway in leukemic cell lines: I. Leroy, et al.; Apoptosis 11, 113 (2006) Abstract
Further Categories Containing This Product:
DNA Fragmentation & Chromatin Condensation • MDR Inhibitors • Antibiotics - Immunomodulators
 
 
ALX-340-021 Revised 04-Jun-08
MK-571 . sodium salt
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Leukotrienes Other Products
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ALX-340-021-M005   5 mg 45.00 USD Add To Cart
ALX-340-021-M025   25 mg 190.00 USD Add To Cart
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Product Specification
FORMULA: C26H26ClN2O3S2 . Na
MW: 514.1 . 23.0
CAS NUMBER: 115104-28-4
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to light yellow solid.
SOLUBILITY: Soluble in water (20mg/ml), aqueous buffers, 100% ethanol (10mg/ml) or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Aqueous stock solutions may be stable for more than 24 hours but we recommend making a fresh preparation before use.
HANDLING: Hygroscopic.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Leukotriene LTD4 receptor antagonist that potently inhibits MRP1.
Product Specific Literature References
The leukotriene LTD4 receptor antagonist MK571 specifically modulates MRP associated multidrug resistance: V. Gekeler, et al.; BBRC 208, 345 (1995) Abstract
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide: L. Vernhet, et al.; Biochem. Pharmacol. 61, 1387 (2001) Abstract
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic: J. Liu, et al.; Mol. Pharmacol. 60, 302 (2001) Abstract
P-Glycoprotein and transporter MRP1 reduce HIV protease inhibitor uptake in CD4 cells: potential for accelerated viral drug resistance?: K. Jones, et al.; Aids 15, 1353 (2001) Abstract
Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells: U. Stein, et al.; Int. J. Cancer 97, 751 (2002) Abstract
Further Categories Containing This Product:
MDR Inhibitors
 
 
ALX-801-036 Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (BXP-53)
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SYNONYMS anti-BCRP MAb (BXP-53)
anti-MXR MAb (BXP-53)
anti-ABCG2 MAb (BXP-53)
anti-CD338 MAb (BXP-53)
PRODUCT LINE Cancer
PRODUCT CATEGORY Breast Cancer Resistance Protein [BCRP / MXR] / Related Products
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ALX-801-036-C125   125 µg 350.00 USD Add To Cart
ALX-801-036-C250   250 µg 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: BXP-53
ISOTYPE: Rat IgG2a
CONCENTRATION: ~250µg/ml
FORMULATION: Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN: Recombinant mouse BCRP (breast cancer resistance protein; MXR) (aa 221-394).
SPECIFICITY: Recognizes an internal epitope of human and mouse BCRP.
APPLICATION: Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections, paraffin sections): Use 1:20 on acetone fixed frozen sections followed by incubation with biotin-labelled rabbit anti-rat IgG and HRP-labelled streptavidin.
For paraffin sections see [1].
Western Blot: Use 1:20-1:50 dilution and  HRP-labelled anti-rat IgG.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
[1] The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria: J.W. Jonker, et al.; PNAS 99, 15649 (2002) Abstract; Full Text
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies • CD Antibodies
 
 
ALX-801-029 Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (human) (BXP-21)
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SYNONYMS anti-BCRP (human) MAb (BXP-21)
anti-MXR (human) MAb (BXP-21)
anti-ABCG2 (human) MAb (BXP-21)
anti-CD338 (human) MAb (BXP-21)
PRODUCT LINE Cancer
PRODUCT CATEGORY Breast Cancer Resistance Protein [BCRP / MXR] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-029-C125   125 µg 350.00 USD Add To Cart
ALX-801-029-C250   250 µg 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: BXP-21
ISOTYPE: Mouse IgG2a
CONCENTRATION: ~250µg/ml
FORMULATION: Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN: Recombinant human BCRP (breast cancer resistance protein; MXR) (aa 271-396).
SPECIFICITY: Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1 or MRP2.
APPLICATION: Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry:
Frozen sections: Use 1:20 dilution on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex.
Paraffin sections: Use on formaldehyde-fixed paraffin-embedded human tissues and tumors after pretreatment with 10mM citric acid, pH 6.0, for 20 min.
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001) Abstract; Full Text
Characterization of Drug Transport, ATP Hydrolysis, and Nucleotide Trapping by the Human ABCG2 Multidrug Transporter : C. Özvegy, et al.; J. Biol. Chem. 277, 47980 (2002) Abstract; Full Text
General Literature References
A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS 95, 15665 (1998) Abstract; Full Text
Further Categories Containing This Product:
Tumor Markers • Monoclonal Antibodies
 
 
ALX-801-027 Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (human) (BXP-34)