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ALX-430-063
Revised 10-Oct-07
Anthralin
SYNONYMS
Dithranol
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Leukotrienes Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-430-063-G001
1 g
25.00 USD
Product Specification
FORMULA:
C
14
H
10
O
3
MW:
226.2
CAS NUMBER:
1143-38-0
MERCK INDEX:
14:
684
RTECS:
CB8927000
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow powder.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
MAY BE MUTAGENIC. IRRITANT.
Product Description
Leukotriene biosynthesis inhibitor. Inhibits LTB
4
ω-oxidation.
Product Specific Literature References
Anthralin (1,8-dihydroxyanthrone) is a potent inhibitor of leukotriene production and LTB4-omega oxidation by human neutrophils:
J.M. Schröder; J. Invest. Dermatol.
87
, 624 (1986)
Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
•
Cancer Other Products
ALX-153-064
Revised 31-Aug-07
Caveolin-1 Scaffolding Domain Peptide
SYNONYMS
Cavtratin
AP-Cav
Pen-C1-SD
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Caveolae / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-153-064-M001
1 mg
140.00 USD
ALX-153-064-M005
5 mg
560.00 USD
Product Specification
SEQUENCE:
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Asp-Gly-Ile-Trp-Lys-Ala-Ser-Phe-Thr-Thr-Phe-Thr-Val-Thr-Lys-Tyr-Trp-Phe-Tyr-Arg-OH
FORMULA:
C
228
H
335
N
61
O
49
S
MW:
4746.6
APPEARANCE:
≥97% (HPLC)
SOLUBILITY:
Soluble in DMSO or acentonitrile:water (50:50).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Hygroscopic. Protect from light.
HAZARD:
MAY BE CARCINOGENIC. HARMFUL.
Product Description
Cell permeable peptide that blocks eNOS (NOS III) activity and cellular nitric oxide (NO) release
in vitro
and reduces inflammation and tumorigenesis
in vivo
. Caveolin-1 interacts with several lipid-modified signalling ligands, such as EGFR, eNOS, G-protein α-subunits, PKCα, H-Ras, and Src, via the C1-SD82-101 sequence.
Product Specific Literature References
Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane:
T. Okamoto, et al.; J. Biol. Chem.
273
, 4519 (1998)
Abstract
;
Full Text
In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation:
M. Bucci, et al.; Nat. Med.
6
, 1362 (2000)
Abstract
;
Full Text
Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice:
J.P. Gratton, et al.; Cancer Cell
4
, 31 (2003)
Abstract
;
Full Text
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion:
T.M. Williams, et al.; J. Biol. Chem.
279
, 51630 (2004)
Abstract
;
Full Text
Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides:
P.N. Bernatchez, et al.; PNAS
102
, 761 (2005)
Abstract
;
Full Text
Further Categories Containing This Product:
NOS Regulation
•
Peptides
•
Cancer Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
APO-54N-032
Revised 18-Jun-08
ILEI (human) Detection Set [For ELISA Application]
SYNONYMS
Interleukin-like EMT Inducer (human) Detection Set [For ELISA Application]
FAM3C (human) Detection Set [For ELISA Application]
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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APO-54N-032-KI01
1 Set
630.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SENSITIVITY:
200 pg/ml (range 0 to 20 ng/ml).
QUANTITY:
For 5x96 wells.
KIT/SET CONTAINS:
1 vial Standard (lyophilized) (STD).
1 vial Coating Antibody (COAT).
1 vial Detection Antibody (DET).
APPLICATION:
For the quantitative determination of human ILEI from biological fluids (serum, plasma and cell culture supernatant).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92520:
FAM3C (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
•
Cancer Other Products
•
ELISA Sets
ALX-522-137
Revised 18-Jun-08
ILEI (human) (recombinant)
SYNONYMS
Interleukin-like EMT Inducer (human) (recombinant)
FAM3C (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-137-C010
10 µg
360.00 USD
Product Specification
MW:
~25kDa
SOURCE/HOST:
Produced in CHO cells. Human ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG
®
-tag
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q92520:
FAM3C (human)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Cancer Other Products
•
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
ALX-522-119
Revised 18-Jun-08
ILEI (mouse) (recombinant)
SYNONYMS
Interleukin-like EMT Inducer (mouse) (recombinant)
FAM3C (mouse) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-522-119-C010
10 µg
360.00 USD
Product Specification
MW:
~25kDa
SOURCE/HOST:
Produced in HEK 293 cells. Mouse ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG
®
-tag
CONCENTRATION:
0.1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q91VU0:
FAM3C (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Cancer Other Products
•
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
ALX-201-246
Revised 24-Apr-08
Matriptase (human) (recombinant)
SYNONYMS
MT-SP1 (human) (recombinant)
Membrane-type Serine Protease 1 (human) (recombinant)
ST14 (human) (recombinant)
Suppression of Tumorigenicity Protein 14 (human) (recombinant)
TADG-15 (human) (recombinant)
Tumor-associated Differentially Expressed Gene 15 Protein (human) (recombinant)
SNC19 (human) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-201-246-U125
125 U
360.00 USD
Product Specification
MW:
~25kDa
SOURCE/HOST:
Recombinant human matriptase (aa 596-855) fused at the N-terminus to a His-tag.
CONCENTRATION:
100nM
PURITY:
≥98% (SDS-PAGE)
FORMULATION:
Liquid. In 100mM TRIS, pH 9.0, containing 200mM sodium chloride, 1mM β-mercaptoethanol and 10% glycerol.
ACTIVITY:
Trypsin-like serine protease.
SPECIFIC ACTIVITY:
~2.5U/µl. One unit is defined as the amount of enzyme that releases 1nmol of AMC per min. at 37°C in the presence of 50µM of Boc-Gln-Ala-Arg-AMC.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 6 months when stored at -20°C. Do not store diluted solutions.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Reverse biochemistry: use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue:
T. Takeuchi, et al.; PNAS
96
, 11054 (1999)
Abstract
;
Full Text
Inhibition of human matriptase by eglin c variants:
A. Désilets, et al.; FEBS Lett.
580
, 2227 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Recommended Assay Buffer:
100mM TRIS, pH 9.5, containing 5mg/ml BSA.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Cytoskeleton & Extracellular Matrix Other Products
•
Cancer Other Products
ALX-804-624
Revised 20-Jun-05
Monoclonal Antibody to Doxorubicin (MAD11)
SYNONYMS
anti-DXR MAb (MAD11)
anti-14-Hydroxydaunomycin MAb (MAD11)
anti-Adriamycin MAb (MAD11)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-624-C100
100 µg
320.00 USD
Product Specification
CLONE:
MAD11
ISOTYPE:
Mouse IgG2
CONCENTRATION:
FORMULATION:
Liquid. Purified antibody containing 150mM sodium chloride and 0.02% sodium azide, pH 7.4.
IMMUNOGEN:
Doxorubicin-BSA.
SPECIFICITY:
Recognizes anthracycline compounds including doxorubicin analogs and derivatives.
APPLICATION:
ELISA
Immunohistochemistry
Functional Application:
In vivo
antidotic effect.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
HANDLING:
Do not freeze.
Product Specific Literature References
Monoclonal antibodies against doxorubicin:
A. Balsari, et al.; Int. J. Cancer
42
, 798 (1988)
Abstract
A new monoclonal antibody recognizing anthracyclinic molecule:
A. Balsari, et al.; Anticancer Res.
10
, 129 (1990)
Abstract
Anti-drug monoclonal antibodies antagonize toxic effect more than anti-tumor activity of doxorubicin:
A. Balsari, et al.; Int. J. Cancer
47
, 889 (1991)
Abstract
An anti-doxorubicin monoclonal antibody modulates kinetic and dynamic characteristics of the drug:
A. Sardini, et al.; Int. J. Cancer
50
, 617 (1992)
Abstract
Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies:
A.L. Balsari, et al.; FASEB J.
8
, 226 (1994)
Abstract
Effect of a bifunctional monoclonal antibody directed against a tumor marker and doxorubicin on the growth of epidermoid vulvar carcinoma grafted in athymic mice:
D. Morelli, et al.; Cell Biophys.
24-25
, 119 (1994)
Abstract
Relevance of antibody valency in EGF receptor modulation:
D. Morelli, et al.; Scand. J. Immunol.
39
, 453 (1994)
Abstract
Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice:
D. Morelli, et al.; Cancer Res.
56
, 2082 (1996)
Abstract
Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats:
R. Cece, et al.; Lab. Invest.
75
, 601 (1996)
Abstract
Intratibial injection of an anti-doxorubicin monoclonal antibody prevents drug-induced myelotoxicity in mice:
D. Morelli, et al.; Br. J. Cancer
75
, 656 (1997)
Abstract
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice:
A. Balsari, et al.; Br. J. Cancer
85
, 1964 (2001)
Abstract
Role of proliferation in HER2 status predicted response to doxorubicin:
M. Campiglio, et al.; Int. J. Cancer
105
, 568 (2003)
Abstract
Further Categories Containing This Product:
Topoisomerases Other Products
•
Antibiotics - Topoisomerase Inhibitors
•
Cancer Other Products
•
Monoclonal Antibodies
ALX-804-652
Revised 22-Feb-07
Monoclonal Antibody to HERG1 (human) (A12)
SYNONYMS
anti-Erg1 (human) MAb (A12)
anti-Ether-a-go-go Related Protein 1 (human) MAb (A12)
anti-KCNH2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Kv11.1 (human) MAb (A12)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
K+ Channel Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-652-R300
300 µl
390.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
A12
ISOTYPE:
Mouse IgG2b
FORMULATION:
Liquid. Ascites.
IMMUNOGEN:
Synthetic peptide corresponding to aa 575-588 (E
575
QPHMDSRIGWLHN
588
) of the extracellular loop S5-P of HERG1 (human ether-a-go-go related protein 1).
SPECIFICITY:
Recognizes the extracellular loop S5-P of HERG1.
APPLICATION:
Flow Cytometry (1:2-1:50)
Immunocytochemistry (1:50-1:200)
Immunohistochemistry (paraffin sections) (1:50-1:200)
Immunoprecipitation (3-5µl)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
The ether-a-go-go related gene family of K
+
channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products
•
Monoclonal Antibodies
ALX-804-857
Revised 18-Jun-08
Monoclonal Antibody to ILEI (Delphy-1)
SYNONYMS
anti-Interleukin-like EMT Inducer MAb (Delphy-1)
anti-FAM3C MAb (Delphy-1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Chemokines & Cytokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-804-857-C100
100 µg
360.00 USD
ALX-804-857B-C100
Biotin
100 µg
395.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE:
Delphy-1
ISOTYPE:
Mouse IgG2a
SOURCE/HOST:
Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:
1mg/ml
PURITY:
≥95% (SDS-PAGE)
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human ILEI (aa 42-227).
SPECIFICITY:
Recognizes human and mouse ILEI.
APPLICATION:
ELISA
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored as recommended.
HANDLING:
For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.
General Information
In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Cloning, expression, and initial characterization of a novel cytokine-like gene family:
Y. Zhu, et al.; Genomics
80
, 144 (2002)
Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells:
T. Waerner, et al.; Cancer Cell
10
, 227 (2006)
Abstract
Further Categories Containing This Product:
Cancer Other Products
•
Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products
•
Monoclonal Antibodies
ALX-803-300
Revised 31-Oct-06
Monoclonal Antibody to p130Cas (1H9)
SYNONYMS
anti-CRK-associated Substrate MAb (1H9)
anti-CRKAS MAb (1H9)
anti-Breast Cancer anti-estrogen Resistance 1 Protein MAb (1H9)
anti-BCAR1 MAb (1H9)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adaptor Proteins & Interaction Domains Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-803-300-C100
100 µg
240.00 USD
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