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ALX-380-266
Revised 03-Apr-08
Amikacin . disulfate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-266-M250
250 mg
30.00 USD
ALX-380-266-G001
1 g
70.00 USD
Product Specification
FORMULA:
C
22
H
43
N
5
O
13
. 2H
2
SO
4
MW:
585.6 . 196.2
CAS NUMBER:
39831-55-5
MERCK INDEX:
14:
405
RTECS:
WK1961200
SOURCE/HOST:
Semisynthetic from kanamycin A (Prod. No.
ALX-380-275
).
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
ACTIVITY:
Potency is 647-786µg/ml (on dry basis).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Aminoglycoside antibiotic. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
BB-K 8, a new semisynthetic aminoglycoside antibiotic:
H. Kawaguchi, et al.; J. Antibiot.
25
, 695 (1972)
Abstract
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans:
B.E. Cabana & J.G. Taggart; Antimicrob. Agents Chemother.
3
, 478 (1973)
Abstract
Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin:
P.K. Yu & J.A. Washington; Antimicrob. Agents Chemother.
4
, 133 (1973)
Abstract
Pharmacology of amikacin in humans:
G.P. Bodey, et al.; Antimicrob. Agents Chemother.
5
, 508 (1974)
Abstract
Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics:
K. Fujisawa, et al.; J. Antibiot.
27
, 677 (1974)
Abstract
Ototoxicity and pharmacokinetically determined dosages of amikacin in granulocytopenic cancer patients:
F.J. Danhauer, et al.; Clin. Pharm.
1
, 539 (1982)
Abstract
Biological transformation of kanamycin A to amikacin (BBK-8):
L.M. Cappelletti & R. Spagnoli; J. Antibiot.
36
, 328 (1983)
Abstract
Related Products
ALX-380-049
Kanamycin . sulfate
ALX-380-045
Revised 03-Apr-08
Amikacin (free base)
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
Format:
Size:
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Quantity:
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ALX-380-045-G001
1 g
60.00 USD
Product Specification
FORMULA:
C
22
H
43
N
5
O
13
MW:
585.6
CAS NUMBER:
37517-28-5
MERCK INDEX:
14:
405
SOURCE/HOST:
Semisynthetic from kanamycin A (Prod. No.
ALX-380-275
).
PURITY:
≥98% (contains ≤5% water)
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
TOXIC.
Product Description
Aminoglycoside antibiotic derived from kanamycin A. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins:
R.N. Jones, et al.; Antimicrob. Agents Chemother.
22
, 985 (1982)
Abstract
BB-K 8, a new semisynthetic aminoglycoside antibiotic:
H. Kawaguchi, et al.; J Antibiot (Tokyo)
25
, 695 (1972)
Abstract
An overview of amikacin:
A. M. Ristuccia & B. A. Cunha; Ther. Drug Monit.
7
, 12 (1985), Review
Abstract
New uses for older antibiotics: nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline revisited:
B.A. Cunha; Med. Clin. North Am.
90
, 1089 (2006), Review
Abstract
ALX-380-280
Revised 08-Apr-08
Amphotericin B
SYNONYMS
Fungizone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-280-M250
250 mg
65.00 USD
Product Specification
FORMULA:
C
47
H
73
NO
17
MW:
924.1
CAS NUMBER:
1397-89-3
MERCK INDEX:
14:
585
RTECS:
BU2625000
SOURCE/HOST:
Isolated from
Streptomyces sp
.
APPEARANCE:
Yellow to orange powder.
PURITY DETAIL:
Contains 50% sodium deoxycholate for solubilization.
SOLUBILITY:
Soluble in water (20mg/ml), DMSO or dimethyl formamide (30mg/ml).
ACTIVITY:
Potency is 1017µg/mg.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Antibiotic. Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Effective against yeasts and molds.
Product Specific Literature References
Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells:
J. Medoff, et al.; Cancer Res.
35
, 2548 (1975)
Abstract
;
Full Text
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung:
C.A. Presant, et al.; Cancer Treat. Rep.
68
, 651 (1984)
Abstract
Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior:
Biophys. J.; C. Barth, et al.
64
, 92 (1993)
Abstract
Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro:
B.S. Charak, et al.; Br. J. Haematol.
88
, 693 (1994)
Abstract
Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study:
J. Tollemar, et al.; Transplantation
59
, 45 (1995)
Abstract
ALX-380-268
Revised 21-May-08
Ampicillin . sodium salt
SYNONYMS
D-(−)-α-Aminobenzylpenicillin . Na
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-268-G005
5 g
45.00 USD
Product Specification
FORMULA:
C
16
H
18
N
3
O
4
S . Na
MW:
348.4 . 23.0
CAS NUMBER:
69-52-3
MERCK INDEX:
14:
586
RTECS:
XH8400000
SOURCE/HOST:
Semisynthetic from penicillin.
PURITY:
≥95% (Assay)
APPEARANCE:
White to light yellow powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
Product Description
β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria. Is inactivated by β-lactamase.
Product Specific Literature References
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies:
J. Med. Chem.; S.K. Sengupta, et al.
18
, 1175 (1975)
Abstract
N7-Substituted 7-aminoactinomycin D analogues. Synthesis and biological properties:
M.S. Madhavarao, et al.; J. Med. Chem.
21
, 958 (1978)
Abstract
Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use:
D.M. Campoli-Richards & R.N. Brogden; Drugs
33
, 577 (1987)
Abstract
Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis:
S.J. Martin, et al.; J. Immunol.
145
, 1859 (1990)
Abstract
Short exposure to actinomycin D induces "reversible" translocation of protein B23 as well as "reversible" inhibition of cell growth and RNA synthesis in HeLa cells:
B.Y. Yung, et al.; Cancer Res.
50
, 5987 (1990)
Abstract
Schedule-dependent effects of two consecutive, divided, low doses of actinomycin D on translocation of protein B23, inhibition of cell growth and RNA synthesis in HeLa cells:
B.Y. Yung, et al.; Int. J. Cancer
52
, 317 (1992)
Abstract
Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor:
M. Nakajima, et al.; Neurosci. Lett.
176
, 161 (1994)
Abstract
ALX-270-381
Revised 28-Sep-07
Anacardic acid
SYNONYMS
2-Hydroxy-6-pentadecylbenzoic acid
6-Pentadecylsalicylic acid
AA
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Histone Acetyl- & Methyl-Transferases/Related Products
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ALX-270-381-M005
5 mg
40.00 USD
ALX-270-381-M025
25 mg
140.00 USD
Product Specification
FORMULA:
C
22
H
36
O
3
MW:
348.5
MERCK INDEX:
14:
621
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (
1
H-NMR)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
Protect from light. After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas.
Product Description
Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC
50
~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.
Product Specific Literature References
Anacardic Acid: molluscicide in cashew nut shell liquid:
J.T. Sullivan, et al.; Planta Med.
44
, 175 (1982)
Abstract
Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids:
R. Grazzini, et al.; BBRC
176
, 775 (1991)
Abstract
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus:
H. Muroi & I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Small molecule modulators of histone acetyltransferase p300
:
K. Balasubramanyam, et al.; J. Biol. Chem.
278
, 19134 (2003)
Abstract
;
Full Text
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation:
Y. Sun, et al.; FEBS Lett.
580
, 4353 (2006)
Abstract
General Literature References
Antibacterial activity of anacardic acid and totarol, alone and in combination with methicillin, against methicillin-resistant Staphylococcus aureus
:
H. Muroi and I. Kubo; J. Appl. Bacteriol.
80
, 387 (1996)
Abstract
Synthesis of sildenafil analogues from anacardic acid and their phosphodiesterase-5 inhibition
:
R. Paramashivappa, et al.; J. Agric. Food Chem.
50
, 7709 (2002)
Abstract
Further Categories Containing This Product:
Lipoxygenases/Related Products
•
Prostaglandin Synthases/Related Products
•
Antibiotics Other Products
ALX-380-126
Revised 17-Jul-08
Asperloxine A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-126-M001
1 mg
120.00 USD
Product Specification
FORMULA:
C
21
H
19
N
3
O
5
MW:
393.4
SOURCE/HOST:
Isolated from
Aspergillus ochraceus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO, methanol or acetone.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by
1
H-NMR.
Product Description
Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity:
H.B. Bode, et al.; Chembiochem.
3
, 619 (2002)
Abstract
Further Categories Containing This Product:
Benzodiazepines/Related Products
•
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
ALX-380-086
Revised 18-Jan-05
Aurantimycin A
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-086-M001
1 mg
25.00 USD
ALX-380-086-M005
5 mg
100.00 USD
Product Specification
FORMULA:
C
38
H
64
N
8
O
14
MW:
857.0
SOURCE/HOST:
Isolated from
Streptomyces aurantiacus
IMET 43917.
PURITY:
≥97%
SOLUBILITY:
Soluble in DMSO or a mixture of alcohol and chloroform; moderately soluble in alcohols or chloroform.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
Has strong antibiotic activity against Gram-positive bacteria and cytotoxicity. Shows inhibitory effects on cellular adhesion and anaphylatoxin receptor binding.
Product Specific Literature References
Microbial products. VIII. Azinothricin, a novel hexadepsipeptide antibiotic
:
H. Maehr, et al.; J. Antibiot.
39
, 17 (1986)
Abstract
L-156,602, a C5a antagonist with a novel cyclic hexadepsipeptide structure from
Streptomyces sp.
MA6348. Fermentation, isolation and structure determination
:
O.D. Hensens, et al.; J. Antibiot.
44
, 249 (1991)
Abstract
Aurantimycins, new depsipeptide antibiotics from
Streptomyces aurantiacus
IMET 43917. Production, isolation, structure elucidation, and biological activity
:
U. Grafe, et al.; J. Antibiot.
48
, 119 (1995)
Abstract
ALX-380-081
Revised 15-Dec-04
Batumin
SYNONYMS
(2E,10Z,12E)-20-(3-Amino-carboxy-2-methyl-1-oxobutyl)amino-7-methylene-17-oxo-19-oxy-3,5,15-trimethyl-eicosa-2,10,12-triene acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-081-M010
10 mg
90.00 USD
Product Specification
FORMULA:
C
30
H
50
N
2
O
7
MW:
550.7
SOURCE/HOST:
Isolated from
Pseudomonas batumici
.
PURITY:
~80%
APPEARANCE:
Brown oil.
SOLUBILITY:
Soluble in methanol, 100 % ethanol, acetone or pyridine. Slightly soluble in aqueous solutions of alkali. Hardly soluble in water and aqueous solutions of acids. Water soluble salt of batumin may be obtained by addition of NaOH to batumin in 50% ethanol and subsequent removal of ethanol in vacuum and lyophilization.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HAZARD:
TOXIC.
Product Description
Antibiotic with high and selective activity against
Staphylococcus
strains including methicillin-resistant
S. Aureus
(MRSA) strains in a concentration of 1-10ng/ml. Poorly active or no effects against Micrococci and other Gram-positive microorganisms and fungi. Different degree of activity against Gram-negative bacteria. Useful for identification of
Staphylococcus
species in pure and mixed cultures.
Product Specific Literature References
Obtaining a High-activity Strain Capable of Producing the Antistaphylococcal Antibiotic Batumin :
V.V. Smirnov, et al.; Appl. Biochem. Microbiol.
36
, 46 (2000)
Generation of mutants of a strain producing the new antibiotic batumin by means of transposon mutagenesis
:
V.V. Smirnov, et al. ; Appl. Biochem. Microbiol.
36
, 262 (2000)
ALX-380-270
Revised 14-Feb-08
Carbenicillin . disodium salt
SYNONYMS
α-Carboxybenzylpenicillin . 2Na
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
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ALX-380-270-M250
250 mg
35.00 USD
ALX-380-270-G001
1 g
105.00 USD
Product Specification
FORMULA:
C
17
H
16
N
2
O
6
S . 2Na
MW:
376.4 . 46.0
CAS NUMBER:
4800-94-6
MERCK INDEX:
14:
1792
RTECS:
ON9105000
SOURCE/HOST:
Semisynthetic from penicillin.
PURITY:
≥92% (Assay)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
HAZARD:
HARMFUL.
Product Description
Analog to ampicillin (Prod. No.
ALX-380-268
). Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-positive and Gram-negative bacteria and
Pseudomonas
.
Product Specific Literature References
In vitro susceptibility of Pseudomonas species to carbenicillin and trimethoprim-sulfamethoxazole:
S.F. Hill, et al.; J. Clin. Microbiol.
22
, 465 (1985)
Abstract
;
Full Text
Nucleotide sequence and characterization of a carbenicillin-hydrolyzing penicillinase gene from Proteus mirabilis:
Y. Sakurai, et al.; J. Bacteriol.
173
, 7038 (1991)
Abstract
;
Full Text
Stereoselective renal tubular secretion of carbenicillin:
T. Itoh, et al.; Antimicrob. Agents Chemother.
37
, 2327 (1993)
Abstract
;
Full Text
New carbenicillin-hydrolyzing beta-lactamase (CARB-7) from Vibrio cholerae non-O1, non-O139 strains encoded by the VCR region of the V. cholerae genome:
R. Melano, et al.; Antimicrob. Agents Chemother.
46
, 2162 (2002)
Abstract
;
Full Text
Related Products
ALX-380-268
Ampicillin . sodium salt
ALX-380-016
Revised 30-Oct-07
Cefaclor
SYNONYMS
7-(D-2-Amino-2-phenylacetamido)-3-chloro-3-cephem-4-carboxylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
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Format:
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Unit Price:
Quantity:
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ALX-380-016-M050
50 mg
20.00 USD
ALX-380-016-M250
250 mg
50.00 USD
ALX-380-016-G001
1 g
150.00 USD
ALX-380-016-G005
5 g
350.00 USD
Product Specification
