• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Cancer
You are here: Product Lines > Cancer
 
Toolbar - View Selection
 
 Items 150-200 of 898 Page 4 of 18 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-385-009 Revised 03-Apr-08
Chrysin
Add to Clipboard
SYNONYMS 5,7-Dihydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-009-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H10O4
MW: 254.2
CAS NUMBER: 480-40-0
MERCK INDEX: 14: 2256
RTECS: LK8329050
PURITY: ≥96%
APPEARANCE: Yellow to tan solid.
SOLUBILITY: Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells: K.J. Woo, et al.; Biochem. Biophys. Res. Commun. 325, 1215 (2004) Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase: M.S. Weng, et al.; Biochem. Pharmacol. 69, 1815 (2005) Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism:: Y.J. Moon, et al.; Toxicol. In Vitro 20, 187 (2006), (Review) Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis: B. Fu, et al.; Mol. Cancer Ther. 6, 220 (2007) Abstract
Further Categories Containing This Product:
Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Antitumor Reagents • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-380-112 Revised 03-Apr-08
Chrysomycin A
Add to Clipboard
SYNONYMS Chrysomycin V
Virenomycin V
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-112-C250   250 µg 140.00 USD Add To Cart
ALX-380-112-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C28H28O9
MW: 508.5
CAS NUMBER: 82196-88-1
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to greenish solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: Protect from light also when in solution.

Product Description
Antibiotic. Inhibits topoisomerase II in human. Mediates a unique cross-linking reaction between DNA and histidine H3. Antineoplastic and photosensitizing compound. Exhibits antitumor activity against human cell lines.
Product Specific Literature References
Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69, 280 (1955) Abstract
The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. (Tokyo) 35, 1194 (1982) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
Related Products
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-380-114 Revised 03-Apr-08
Chrysomycin B
Add to Clipboard
SYNONYMS Chrysomycin M
Virenomycin M
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-114-C250   250 µg 140.00 USD Add To Cart
ALX-380-114-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C27H28O9
MW: 496.5
CAS NUMBER: 83852-56-6
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; slightly soluble in 100% ethanol or methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: Protect from light.

Product Description
Antibiotic. Inhibits topoisomerase II in human. Mediates a unique cross-linking reaction between DNA and histidine H3. Antineoplastic and photosensitizing compound. Exhibits antitumor activity against human cell lines. Less potent than Chrysomycin A (Prod. No. ALX-380-112).
Product Specific Literature References
Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69, 280 (1955) Abstract
The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. (Tokyo) 35, 1194 (1982) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
Related Products
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-260-005 Revised 03-Mar-05
Chymostatin
Add to Clipboard
SYNONYMS (S)-1-Carboxy-2-phenylethyl)-carbamoyl-α-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
PRODUCT LINE Cancer
PRODUCT CATEGORY Cathepsin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-005-M001   1 mg 22.00 USD Add To Cart
ALX-260-005-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C21H38N4O8
MW: 605.0 (average)
CAS NUMBER: 9076-44-2
SOURCE/HOST: Microbial.
SOLUBILITY: Soluble in DMSO (20 mg/ml) or glacial acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of serine proteinases having a chymotrypsin-like specificity like α-, β-, δ- and γ-chymotrypsin, chymases, cathepsin G, and most cysteine proteinases including papain and cathepsin A, B, H, and L. Mixture of type A (R=L-Leu), type B (R=L-Val), type C (R=L-Ile).
Product Specific Literature References
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes: H. Umezawa, et al.; J. Antibiot. 23, 425 (1970) Abstract
Further Categories Containing This Product:
Proteases Other Products
 
 
ALX-350-283 Revised 11-Jun-07
Cinobufagin
Add to Clipboard
SYNONYMS 5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - ATPase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-283-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C26H34O6
MW: 442.6
CAS NUMBER: 470-37-1
PURITY: ≥99%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Specific Na+/K+-ATPase inhibitor. About as active as ouabain (Prod. No. ALX-350-066).
Product Specific Literature References
Metabolism and pharmacokinetics of cinobufagin: S. Toma, et al.; Xenobiotica 17, 1195 (1987) Abstract
Specific 12 beta-hydroxylation of cinobufagin by filamentous fungi: M. Ye, et al.; Appl. Environ. Microbiol. 70, 3521 (2004) Abstract
Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells: O.A. Akimova, et al.; J. Biol. Chem. 280, 832 (2005) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Na+ / K+-ATPase / Related Products • Natural Products - Immunomodulators • Antitumor Agents (Anti-proliferative)
 
 
ALX-380-287 Revised 15-Apr-08 New product
Ciprofloxacin
Add to Clipboard
SYNONYMS 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1- piperazinyl)-3-quinolinecarboxylic acid
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-287-G005   5 g 20.00 USD Add To Cart
ALX-380-287-G025   25 g 60.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3
MW: 331.3
CAS NUMBER: 85721-33-1
MERCK INDEX: 14: 2314
RTECS: VB1993800
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in dilute hydrochloric acid; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.
Product Specific Literature References
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986) Abstract
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M DeVito; Clin. Pharm. 6, 105 (1987) Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987) Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-380-288 Revised 08-Aug-08 New product
Ciprofloxacin . hydrochloride
Add to Clipboard
SYNONYMS 1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-288-G005   5 g 20.00 USD Add To Cart
ALX-380-288-G025   25 g 55.00 USD Add To Cart
Product Specification
FORMULA: C17H18FN3O3 . HCl . H2O
MW: 331.3 . 36.5 . 18.0
CAS NUMBER: 86393-32-0
MERCK INDEX: 14: 2314
PURITY: ≥88.5% (Assay)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (35mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria. Effective against Mycobacterium tuberculosis. Potentially anxiogenic.
Product Specific Literature References
Is ciprofloxacin active against clinically important anaerobes?: B. Watt & F.V. Brown; J. Antimicrob. Chemother. 17, 605 (1986) Abstract
Ciprofloxacin and norfloxacin, two fluoroquinolone antimicrobials: D.E. Nix & J.M. DeVito; Clin. Pharm. 6, 105 (1987) Abstract
Mechanisms of action of and resistance to ciprofloxacin: D.C. Hooper, et al.; Am. J. Med. 82, 12 (1987) Abstract
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
Anxiogenic potential of ciprofloxacin and norfloxacin in rats: S. Sen, et al.; Singapore Med. J. 48, 1028 (2007) Abstract; Full Text
Related Products
Further Categories Containing This Product:
Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors
 
 
ALX-400-040 Revised 13-Aug-07
Cisplatin
Add to Clipboard
SYNONYMS cis-Platinum(ll)diamine dichloride
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Reagents Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-040-M050   50 mg 42.00 USD Add To Cart
ALX-400-040-M250   250 mg 90.00 USD Add To Cart
Product Specification
FORMULA: Cl2H6N2Pt
MW: 300.0
CAS NUMBER: 15663-27-1
MERCK INDEX: 14: 2317
RTECS: TP2450000
PURITY: ≥99% (Assay)
APPEARANCE: Off-white to orange powder.
ENDOTOXIN CONTENT: ≤1.0EU/mg
SOLUBILITY: Soluble in dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Specific Literature References
Cisplatin induces a persistent activation of JNK that is related to cell death: I. Sanchez-Perez, et al.; Oncogene 16, 533 (1998) Abstract
Telomere loss in cells treated with cisplatin: T. Ishibashi & S.J. Lippard; PNAS 95, 4219 (1998) Abstract
Mitochondrial changes during the apoptotic process of HeLa cells exposed to cisplatin: J. Melendez-Zajgla, et al.; Biochem. Mol. Biol. Int. 47, 765 (1999) Abstract
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage: J.G. Gong, et al.; Nature 399, 806 (1999) Abstract
Cisplatin-induced apoptosis in human proximal tubular epithelial cells is associated with the activation of the Fas/Fas ligand system: M.S. Razzaque, et al.; Histochem. Cell Biol. 111, 359 (1999) Abstract
Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma: K. Seki, et al.; Cancer Chemother. Pharmacol. 45, 199 (2000) Abstract
Effectiveness of hsp90 inhibitors as anti-cancer drugs: L. Xiao, et al.; Mini Rev. Med. Chem. 6, 1137 (2006), (Review) Abstract
Further Categories Containing This Product:
HSP90 / HtpG / Related Products
 
 
ALX-270-314 Revised 04-Dec-07
CL-387,785
Add to Clipboard
SYNONYMS EKI-785
N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-314-M001   1 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C18H13BrN4O
MW: 381.2
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from light. Packaged under inert gas.

Product Description
Irreversibly inhibits EGF-stimulated autophosphorylation of tyrosine residues in the epidermal growth factor receptor (EGFR) in vivo (IC50=250-490pM) and blocks EGF-mediated growth.
Product Specific Literature References
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-2-butynamide (CL-387,785): C.M. Discafani, et al.; Biochem. Pharmacol. 57, 917 (1999) Abstract
 
 
ALX-380-289 Revised 05-Aug-08 New product
Clinafloxacin
Add to Clipboard
SYNONYMS 7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-289-M250   250 mg