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Matrix Metalloproteinases [MMPs] / Related Products
You are here: Product Lines > Cancer > Matrix Metalloproteinases [MMPs] / Related Products
 
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ALX-210-753 Revised 16-Nov-07
Polyclonal Antibody to MMP-2
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SYNONYMS anti-Matrix Metalloproteinase 2 PAb
anti-Gelatinase (72kDa) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-753-R500   500 µl 197.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: MMP-2 (matrix metalloproteinase 2) from human synovial fibroblasts.
SPECIFICITY: Recognizes human and marmoset MMP-2. Moderately cross-reacts with MMP-1. Does not cross-react with MMP-3, MMP-8 or MMP-9.
CROSSREACTIVITY PROTEINS: MMP-1 from human and marmoset (moderately).
APPLICATION: Immunoprecipitation (1:50-1:150)
Western Blot (1:800-1:2’500)
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix: S. Okada, et al.; Lab. Invest. 72, 311 (1995) Abstract
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix: B.K. Pilcher, et al.; J. Cell Biol. 137, 1445 (1997) Abstract
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium: O. Lindy, et al.; Arthritis Rheum. 40, 1391 (1997) Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-877 Revised 21-Dec-06
Polyclonal Antibody to MMP-3
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SYNONYMS anti-Matrix Metalloproteinase 3 PAb
anti-Procollagenase PAb
anti-Proteoglycanase PAb
anti-Stromelysin-1 PAb
anti-Transin-1 PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-877-C100   100 µg 363.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From guinea pig.
FORMULATION: Liquid. Purified IgG fraction in PBS. Contains no preservatives.
IMMUNOGEN: MMP-3 (matrix metalloproteinase 3) from rabbit synovial fibroblasts.
SPECIFICITY: Recognizes human, rabbit and marmoset MMP-3. Does not cross-react with MMP-1, MMP-2, MMP-8 or MMP-9.
APPLICATION: Immunoprecipitation (10-30µg/ml)
Western Blot (400-900ng/ml).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-756 Revised 11-Jun-07
Polyclonal Antibody to MMP-9
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SYNONYMS anti-Matrix Metalloproteinase 9 PAb
anti-Gelatinase B PAb
anti-Gelatinase (92kDa) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-756-C100   100 µg 272.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS containing 0.01% thimerosal.
IMMUNOGEN: MMP-9 (matrix metalloproteinase 9) from human buffy coats.
SPECIFICITY: Recognizes human and marmoset MMP-9. Cross-reacts very slightly with MMP-2. Does not cross-react with collagenases.
APPLICATION: Immunohistochemistry (1:40-1:150)
Immunoprecipitation (1:20-1:60)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-833 Revised 07-Nov-07
Polyclonal Antibody to MMP-13 (human)
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SYNONYMS anti-Matrix Metalloproteinase 13 (human) PAb
anti-Collagenase-3 (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Antibodies
Ordering Information
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ALX-210-833-R100   100 µl 520.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In PBS, pH 7.5, containing 0.01% thimerosal.
IMMUNOGEN: Recombinant human MMP-13 (matrix metalloproteinase 13).
SPECIFICITY: Recognizes human MMP-13. Does not cross-react with human MMP-2, MMP-9, MMP-14, MMP-15, MMP-16 or MMP-17.
APPLICATION: ELISA (detection; 1:2’000-1:4’000)
Western Blot (ECL-detection; 1:2’500 - 1:8’000)
Note: For capture antibody use MAb to MMP-13 (Prod. No. ALX-804-365).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-834 Revised 04-Dec-04
Polyclonal Antibody to MMP-14 (human)
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SYNONYMS anti-Matrix Metalloproteinase 14 (human) PAb
anti-Membrane-type 1 Matrix Metalloproteinase (human) PAb
anti-MT1-MMP (human) PAb
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY MMP Antibodies
Ordering Information
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ALX-210-834-R100   100 µl 520.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Purified. Contains 0.01% thimerosal.
IMMUNOGEN: Synthetic peptide derived from hinge region between catalytic domain and hemopexin domain of MMP-14 (matrix metalloproteinase 14).
SPECIFICITY: Recognizes human MMP-14. Does not cross-react with human MMP-15.
APPLICATION: ELISA
Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-200-426 Revised 26-Jun-08
TIMP-1 (human)
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SYNONYMS Tissue Inhibitor of Metalloproteinase 1 (human)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Tissue Inhibitors of Matrix Metalloproteinases [TIMPs] / Related Products
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ALX-200-426-C005   5 µg 197.00 USD Add To Cart
Product Specification
MW: ~28kDa.
SOURCE/HOST: Isolated from stimulated human neutrophils. The secreted protein consists of 184 amino acids, six disulfide bonds and two glycosylation sites containing N-linked oligosaccharides.
CONCENTRATION: 80µg/ml
PURITY: ≥92% (SDS-PAGE, Western blot)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.0, 200mM NaCl, 5mM CaCl2, 1µM ZnCl2, 0.05% BRIJ 35 and 0.05% sodium azide.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
Specific inhibitor of matrix metalloproteinases (MMPs). It has no activity on mammalian membrane metalloproteinases, procollagen peptidase or on bacterial metalloproteinases such as thermolysin.
Product Specific Literature References
The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor: T.E. Cawston, et al.; Biochem. J. 211, 313 (1983) Abstract
Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes: G. Murphy, et al.; Biochem. J. 248, 265 (1987) Abstract
Tissue inhibitor of metalloproteinase (TIMP-2). A new member of the metalloproteinase inhibitor family: W.G. Stettler-Stevenson, et al.; J. Biol. Chem. 264, 17374 (1989) Abstract; Full Text
Generation and activity of the ternary gelatinase B/TIMP-1/LMW-stromelysin-1 complex: H. Kolkenbrock, et al.; Biol. Chem. 376, 495 (1995) Abstract
Progelatinase B forms from human neutrophils. complex formation of monomer/lipocalin with TIMP-1: H. Kolkenbrock, et al.; Biol. Chem. 377, 529 (1996) Abstract
Shedding of the Transferrin Receptor Is Mediated Constitutively by an Integral Membrane Metalloprotease Sensitive to Tumor Necrosis Factor alpha Protease Inhibitor-2: M. Kaup, et al.; J. Biol. Chem. 277, 38494 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Note: It is recommended to perform a preincubation of ~20 min. at 37°C to allow formation of the enzyme-inhibitor complex.

Swiss-Prot link P01033: TIMP-1 (human) (precursor)
AfCS Signalling Gateway link A002285: TIMP-1 (mouse)
Further Categories Containing This Product:
Natural Proteins
 
 
ALX-200-427 Revised 25-Apr-08
TIMP-2 (human)
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SYNONYMS Tissue Inhibitor of Metalloproteinase 2 (human)
PRODUCT LINE Cytoskeleton
PRODUCT CATEGORY Tissue Inhibitors of Matrix Metalloproteinases [TIMPs] / Related Products
Ordering Information
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ALX-200-427-C005   5 µg 212.00 USD Add To Cart
Product Specification
MW: ~21kDa (non-reduced); ~24kDa (reduced) (SDS-PAGE).
SOURCE/HOST: Isolated from human fibroblasts.
CONCENTRATION: 40μg/ml
PURITY: ≥90% (SDS-PAGE, Western blot)
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7, containing 200mM NaCl, 5mM CaCl2, 1µM ZnCl2, 0.05% BRIJ 35 and 0.05% sodium azide.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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Product Description
Glycoprotein that belongs to a family which takes part in the activation and regulation of the MMP-activity. Forms a non-covalent stoichiometric complex with latent and active MMP's. Inhibits the activities of MMP-1, MMP-2, MMP-12 and transin.
Product Specific Literature References
Purification and characterization of a two-chain form of tissue inhibitor of metalloproteinases (TIMP) type 2 and a low molecular weight TIMP-like protein: K. Miyazaki, et al.; J. Biol. Chem. 268, 14387 (1993) Abstract; Full Text
Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4: J. Greene, et al.; J. Biol. Chem. 271, 30375 (1996) Abstract; Full Text
Shedding of the Transferrin Receptor Is Mediated Constitutively by an Integral Membrane Metalloprotease Sensitive to Tumor Necrosis Factor alpha Protease Inhibitor-2: M. Kaup, et al.; J. Biol. Chem. 277, 38494 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION

Note: It is recommended to perform a preincubation of about 20min at 37°C which allows the formation of the enzyme-inhibitor complex.

Swiss-Prot link P16035: TIMP-2 (human) (precursor)
AfCS Signalling Gateway A002286: TIMP-2 (mouse)
Further Categories Containing This Product:
Natural Proteins
 
 
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