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Angiopoietins & Tie Receptors / Related Products
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ALX-201-314 Revised 18-Mar-08
COMP (rat):Angiopoietin-1 (human) (recombinant)
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SYNONYMS COMP (rat):Ang-1 (human) (recombinant)
PRODUCT LINE Cancer
PRODUCT CATEGORY Angiopoietins & Tie Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-314-C010   10 µg 360.00 USD Add To Cart
ALX-201-314-C050   50 µg 980.00 USD Add To Cart
ALX-201-314-C500   500 µg 3'200.00 USD Add To Cart
ALX-201-314-M001   1 mg 5'800.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells. The fibrinogen-like domain (aa 284-498) of human Ang-1 (angiopoietin-1) is fused at the N-terminus to the coiled-coil domain of rat COMP (cartilage oligomeric matrix protein) and to a FLAG®-tag.
CONCENTRATION: 0.3mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS containing 0.01% CHAPS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; BioWhittaker)
SPECIFICITY: Binds to human Tie-2.
BIOLOGICAL ACTIVITY: Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
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Product Description
Soluble, stable and more potent Ang-1 variant.
Product Specific Literature References
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity: C.H. Cho, et al.; PNAS 101, 5547 (2004) Abstract; Full Text
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis: C.H. Cho, et al.; PNAS 101, 5553 (2004) Abstract; Full Text
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2: P. Saharinen, et al.; J. Cell Biol. 169, 239 (2005) Abstract
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation: T. Morisada, et al.; Blood 105, 4649 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15389: Angiopoietin-1 (human)
Swiss-Prot link P35444: COMP (rat)

FLAG is a registered trademark of Sigma-Aldrich Co.

Please also see our Product Flyer "COMP:Angiopoietin-1, More Stable, Active and Potent".
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-313 Revised 18-Mar-08
Angiopoietin-1 (human) (recombinant)
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SYNONYMS Ang-1 (human) (recombinant)
PRODUCT LINE Cancer
PRODUCT CATEGORY Angiopoietins & Tie Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-313-C010   10 µg 295.00 USD Add To Cart
ALX-201-313-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells. Human Ang-1 (angiopoietin-1) (aa 20-498) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: ~0.2mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS containing 0.02% CHAPS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker)
BIOLOGICAL ACTIVITY: Induces the phosphorylation of Tie-2 in primary cultured human vascular endothelial cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Working aliquots are stable for up to 6 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15389: Angiopoietin-1 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-315 Revised 18-Mar-08
Angiopoietin-2 (human) (recombinant)
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SYNONYMS Ang-2 (human) (recombinant)
PRODUCT LINE Cancer
PRODUCT CATEGORY Angiopoietins & Tie Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-315-C010   10 µg 295.00 USD Add To Cart
ALX-201-315-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in CHO cells. Human Ang-2 (angiopoietin-2) (aa 19-496) is fused at the N-terminus to a FLAG®-tag.
CONCENTRATION: 0.2mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm filtered solution in PBS containing 0.02% CHAPS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL test; Bio Whittaker)
BIOLOGICAL ACTIVITY: Induces the phosphorylation of Tie-2 in primary cultured human vascular endothelial cells.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 6 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link O15123: Angiopoietin-2 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-270-434 Revised 18-Apr-06
Tie-2 Inhibitor 13
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SYNONYMS (1Z)-5-Fluoro-2-methyl-1-(3-thienylmethylene)-1H-indene-3-acetic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Angiopoietins & Tie Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-434-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C17H13FO2S
MW: 300.6
CAS NUMBER: 857250-95-4
PURITY: ≥95%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Potent and cell permeable Tie-2 inhibitor (IC50=600nm).
Product Specific Literature References
Inhibition of angiogenesis-relevant receptor tyrosine kinases by sulindac analogues: E. Gourzoulidou, et al.; Chembiochem. 6, 527 (2005) Abstract
Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity: J. Hoffmann, et al.; FASEB J. 19, 2035 (2005) Abstract
 
 
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