Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> Cancer
14-3-3 Proteins/Related Products
Angiogenesis
Antibiotics for Cancer Research
Antimicrobial Peptides & Proteins/Related Products
Antitumor Reagents
Carcinogens & Tumor Promoters
Cathepsins/Related Products
CD44/Related Products
CEACAM [CD66]/Related Products
Chemopreventive Agents & Inhibitors of Carcinogenesis
Clusterin/Related Products
Dependence Receptors/Related Products
erbB-2/Related Products
Matrix Metalloproteinases [MMPs]/Related Products
Multidrug Resistance [MDR]
Natural Products for Cancer Research
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
p53/Related Products
Topoisomerases/Related Products
Tumor Markers
Tumor Suppressors/Related Products
Cancer Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
160-180
of 889
Page 9
of 45
Select Page:
<<
1
2
3
4
5
6
7
8
9
10
>>
ALX-210-856
Revised 13-Jul-06
Polyclonal Antibody to MRP4 (human)
SYNONYMS
anti-Multidrug Resistance-associated Protein 4 (human) PAb
anti-ABCC4 (human) PAb
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs]/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-856-R200
200 µl
420.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1.5-2.0mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In borate buffer containing 0.1% BSA.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1249-1268 (S
1249
GRLKEYDEPYVLLQNKESL
1268
) of human MRP4 (multidrug resistance-associated protein 4).
SPECIFICITY:
Recognizes human MRP4. Does not cross-react with MRP4 of other species.
APPLICATION:
Western Blot (1:1’000)
Optimal conditions must be determined individually.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
:
J.D. Schuetz, et al.; Nat. Med.
5
, 1048 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-876
Revised 26-Jun-08
Polyclonal Antibody to MMP-1
SYNONYMS
anti-Matrix Metalloproteinase 1 PAb
anti-Collagenase-1 PAb
anti-Interstitial Collagenase PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-876-C100
100 µg
303.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From guinea pig.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. In PBS. Contains no preservatives.
IMMUNOGEN:
Matrix metalloproteinase 1 (MMP-1) from rabbit synovial fibroblasts.
SPECIFICITY:
Recognizes human, rabbit and marmoset MMP-1. Moderately cross-reacts with human MMP-3.
APPLICATION:
ELISA
Flow Cytometry
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot (400-800ng/ml).
Optimal conditions should be determined individually.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption
:
Y. Okada, et al.; Lab. Invest.
72
, 311 (1995)
Abstract
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium
:
O. Lindy, et al.; Arthritis Rheum.
40
, 1391 (1997)
Abstract
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix:
B.K. Pilcher, et al.; J. Cell Biol.
137
, 1445 (1997)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-877
Revised 21-Dec-06
Polyclonal Antibody to MMP-3
SYNONYMS
anti-Matrix Metalloproteinase 3 PAb
anti-Procollagenase PAb
anti-Proteoglycanase PAb
anti-Stromelysin-1 PAb
anti-Transin-1 PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-877-C100
100 µg
363.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From guinea pig.
FORMULATION:
Liquid. Purified IgG fraction in PBS. Contains no preservatives.
IMMUNOGEN:
MMP-3 (matrix metalloproteinase 3) from rabbit synovial fibroblasts.
SPECIFICITY:
Recognizes human, rabbit and marmoset MMP-3. Does not cross-react with MMP-1, MMP-2, MMP-8 or MMP-9.
APPLICATION:
Immunoprecipitation (10-30µg/ml)
Western Blot (400-900ng/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-894
Revised 12-Sep-05
Polyclonal Antibody to Tenascin-W
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cytoskeleton & Extracellular Matrix Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-894-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY:
≥90%
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In TRIS/glycine, pH 8.0, containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant FNIII repeats 7-9 of mouse tenascin-W.
SPECIFICITY:
Recognizes human, mouse and rat tenascin-W.
APPLICATION:
ELISA (1:10’000)
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections, paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development:
A. Scherberich, et al.; J. Cell Sci.
117
, 571 (2004)
Abstract
;
Full Text
Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro:
A. Scherberich, et al.; Oncogene
24
, 1525 (2005)
Abstract
General Literature References
Tenascins:
R. Chiquet-Ehrismann; Int. J. Biochem. Cell Biol.
36
, 986 (2004)
Abstract
Connective tissues: signalling by tenascins:
R. Chiquet-Ehrismann and R.P. Tucker; Int. J. Biochem. Cell Biol.
36
, 1085 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
•
Tumor Markers
ALX-210-910
Revised 29-Feb-08
Polyclonal Antibody to CYLD (human) (AF888)
SYNONYMS
anti-Cylindromatosis Tumor Suppressor Protein (human) PAb (AF888)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-910-C050
50 µg
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.45mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1% BSA and 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 56-70 (G
56
HSRIPSAKGKKNQI
70
) of human CYLD (cylindromatosis tumor suppressor protein).
SPECIFICITY:
Recognizes human CYLD. Detects a band of ~120kDa by Western blot.
APPLICATION:
Immunocytochemistry (on transfected cells; 1:200)
Western Blot (on transfected cells; 1:3'000).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
The tumor suppressor CYLD Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7:
H. Yoshida, et al.; J. Biol. Chem.
280
, 41111 (2005)
Abstract
;
Full Text
General Information
Cylindromas are benign adnexal skin tumors caused by germ line mutations in the CYLD gene. In most cases the second wild type allele is lost in tumor tissue suggesting that CYLD functions as tumor-suppressor. CYLD is a protein of 956 amino acids harboring a functional deubiquitinating domain at the C-terminal end. CYLD was shown to interact with TRAF2, NEMO and TRIP (Trompouki et al.; Brummelkamp et al.; Kovalenko et al.; Regamey et al.). Furthermore, CYLD is a negative regulator of NF-κB activation mediated by TNF family members and IL-1β. Downregulation of NF-κB activity depends on the deubiquitinating activity of CYLD which removes lysine-63 linked ubiquitin chains from target proteins. These findings indicate that cylindromas arise through constitutive NF-κB activation leading to hyperproliferation and tumor growth.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
:
E. Trompouki, et al.; Nature
424
, 793 (2003)
Abstract
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
:
T.R. Brummelkamp, et al.; Nature
424
, 797 (2003)
Abstract
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
:
A. Kovalenko, et al.; Nature
424
, 801 (2003)
Abstract
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor
:
A. Regamey, et al.; J. Exp. Med.
198
, 1959 (2003)
Abstract
Further Categories Containing This Product:
Deubiquitination Other Products
•
Polyclonal Antibodies
•
Tumor Suppressors/Related Products
ALX-210-921
Revised 31-Oct-06
Polyclonal Antibody to Nerve Growth Factor Receptor (human) (AT101)
SYNONYMS
anti-NGFR (human) PAb (AT101)
anti-TNFRSF 16 (human) PAb (AT101)
anti-p75
NTR
(human) PAb (AT101)
anti-p75 Neurotrophin Receptor (human) PAb (AT101)
anti-CD271 (human) PAb (AT101)
anti-Low-affinity Nerve Growth Factor Receptor (human) PAb (AT101)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Nerve Growth Factors [NGF] & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-921-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide
IMMUNOGEN:
Recombinant human NGFR (nerve growth factor receptor; p75
NTR
) (Prod. No.
ALX-522-044
).
SPECIFICITY:
Recognizes human NGFR.
APPLICATION:
Western Blot (1:1’000)
Note:
Does not work for Immunoprecipitation.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
An autocrine function of nerve growth factor for cell cycle regulation of vascular endothelial cells:
A. Tanaka, et al.; BBRC
313
, 1009 (2004)
Abstract
p75NTR--live or let die:
A. Nykjaer, et al.; Curr. Opin. Neurobiol.
15
, 49 (2005)
Abstract
Further Categories Containing This Product:
Neurotensin/Related Products
•
Polyclonal Antibodies
•
CD Antibodies
ALX-210-922
Revised 26-Aug-05
Polyclonal Antibody to Cornulin (human) (SZ1229)
SYNONYMS
anti-Tumor Related Protein (human) PAb (SZ1229)
anti-C1orf10 Gene Product (human) PAb (SZ1229)
anti-Chromosome 1 Open Reading Frame 10 Gene Product (human) PAb (SZ1229)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Cell Differentiation
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-922-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. In PBS containing 1% BSA and 0.01% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 259-274 (E
259
ATNDQNRGTETHGQG
274
) of human cornulin.
SPECIFICITY:
Recognizes human cornulin. Detects a band of ~70kDa by Western blot.
APPLICATION:
Immunohistochemistry (frozen sections (1:100))
Western Blot (1:2’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
[1]
Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation:
R. Contzler, et al.; J. Invest. Dermatol.
124
, 990 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Tissue Markers
•
Polyclonal Antibodies
•
Tumor Markers
ALX-210-930
Revised 26-Feb-07
Polyclonal Antibody to Clusterin (human) (AT109)
SYNONYMS
anti-TRPM-2 (human) PAb (AT109)
anti-Apolipoprotein J (human) PAb (AT109)
anti-APO-J (human) PAb (AT109)
anti-CLI (human) PAb (AT109)
anti-CLU (human) PAb (AT109)
anti-SGP-2 (human) PAb (AT109)
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Clusterin/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-930-C050
50 µg
180.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human clusterin (aa 23-449).
SPECIFICITY:
Recognizes human clusterin.
APPLICATION:
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Clusterin (human) (recombinant) (Prod.No.
ALX-522-089
)
General Information
Clusterin (SGP-2/sulfated glycoprotein-2; CLI; Apolipoprotein J (Apo J); TRPM-2) is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodelling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Characterization and cloning of androgen-repressed mRNAs from rat ventral prostate
:
J.G. Leger, et al.; BBRC
147
, 196 (1987)
Abstract
Apolipoprotein J: structure and tissue distribution
:
H.V. De Silva, et al.; Biochemistry
29
, 5380 (1990)
Abstract
Clusterin: the intriguing guises of a widely expressed glycoprotein
:
D.E. Jenne & J. Tschopp; Trends Biochem. Sci.
17
, 154 (1992)
Abstract
Clusterin
:
S.E. Jones and C. Jomary; Int. J. Biochem. Cell Biol.
34
, 427 (2002), (Review)
Abstract
Clusterin/Apolipoprotein J in human aging and cancer
:
I. Trougakos and E. Gonos; Int. J. Biochem. Cell Biol.
34
, 1430 (2002)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-937
Revised 28-Apr-08
Polyclonal Antibody to RGMA (human) (AT115)
SYNONYMS
anti-Repulsive Guidance Molecule A (human) PAb (AT115)
anti-RGM Domain Family Member A (human) PAb (AT115)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Growth, Survival and Development of Neurons Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-937-C100
100 µg
360.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human RGMA (aa 48-422) (Prod. No.
ALX-522-103
).
SPECIFICITY:
Recognizes human RGMA.
APPLICATION:
Immunoprecipitation (1:100)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Related Products
ALX-522-134
RGMA, Soluble (mouse) (recombinant)
ALX-522-103
RGMA, Soluble (human) (recombinant)
Further Categories Containing This Product:
Dependence Receptors Other Products
•
Bone Morphogenetic Proteins [BMPs] & Receptors/Related Products
•
Polyclonal Antibodies
ALX-210-939
Revised 11-May-07
Polyclonal Antibody to ZUD (AT116)
SYNONYMS
anti-ZU5 and Death Domain-containing Inhibitor of NF-κB PAb (AT116)
anti-Unc-5 Homolog C
(C. elegans)
-like PAb (AT116)
anti-UNC5CL PAb (AT116)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Netrins & Receptors/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-939-C100
100 µg
380.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Recombinant human ZUD domain (aa 402-518).
SPECIFICITY:
Recognizes human and mouse ZUD.
APPLICATION:
Immunocytochemistry (1:100)
Immunoprecipitation (1:200)
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
