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Tumor Suppressors / Related Products
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Items 9 of 9
ALX-804-254 Revised 14-Aug-07
Monoclonal Antibody to PTEN (6H2.1)
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SYNONYMS anti-Phosphatase and Tensin Homolog Deleted on Chromosome 10 MAb (6H2.1)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PTEN / Related Products
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ALX-804-254-C100   100 µg 480.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: 6H2.1
ISOTYPE: Mouse IgG
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Protein A-affinity purified. Sterile filtered.
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Recombinant human PTEN.
SPECIFICITY: Recognizes human, mouse and rat PTEN (epitope aa 304-403). Detects a band of ~60kDa by Western blot.
APPLICATION: ELISA
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation (5µg)
Western Blot (1-5µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
POSITIVE CONTROL: For Positive Control in Western blot see Prod. No. ALX-201-079.
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Product Specific Literature References
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast: A. Perren, et al.; Am. J. Pathol. 155, 1253 (1999) Abstract; Full Text
PTEN suppresses breast cancer cell growth by phosphatase activity- dependent G1 arrest followed by cell death: L.P. Weng, et al.; Cancer Res. 59, 5808 (1999) Abstract; Full Text
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers: G.L. Mutter, et al.; J. Natl. Cancer Inst. 92, 924 (2000) Abstract
Changes in endometrial PTEN expression throughout the human menstrual cycle: G.L. Mutter, et al.; J. Clin. Endocrinol. Metab. 85, 2334 (2000) Abstract; Full Text
Molecular identification of latent precancers in histologically normal endometrium: G.L. Mutter, et al.; Cancer Res. 61, 4311 (2001) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-804-451 Revised 14-Aug-07
Monoclonal Antibody to PTEN (11G8.1)
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SYNONYMS anti-Phosphatase and Tensin Homolog Deleted on Chromosome 10 MAb (11G8.1)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PTEN / Related Products
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ALX-804-451-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 11G8.1
ISOTYPE: Mouse IgG
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Protein A purified antibody, sterile filtered in PBS.
IMMUNOGEN: Recombinant human PTEN.
SPECIFICITY: Recognizes human and mouse PTEN (epitope aa 152-200). Detects a band of ~60 kDa by Western blot.
APPLICATION: Immunoprecipitation (5µg/sample)
Western Blot (1-5µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
POSITIVE CONTROL: For Positive Control in Western blot see Prod. No. ALX-201-079.
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Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-803-318 Revised 24-Apr-08
Monoclonal Antibody to RUNX3 (human) (R3-6E9)
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SYNONYMS anti-Runt-related Transcription Factor 3 (human) MAb (R3-6E9)
anti-CBF-α3 (human) MAb (R3-6E9)
anti-Core-binding Factor α3 Subunit (human) MAb (R3-6E9)
anti-AML-2 (human) MAb (R3-6E9)
anti-Acute Myeloid Leukemia 2 Protein (human) MAb (R3-6E9)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Transcription Factors Other Products
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ALX-803-318-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: R3-6E9
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300).
SPECIFICITY: Recognizes human RUNX3. Weakly cross-reacts with mouse RUNX3.
APPLICATION: Immunohistochemistry (paraffin sections (2µg/ml)) (see [1])
Immunoprecipitation
Western Blot (0.2µg/ml (see [1]))
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
[1] RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization: K. Ito, et al.; Cancer Res. 65, 7743 (2005) Abstract; Full Text
[2] RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer: Q.C. Lau, et al.; Cancer Res. 66, 6512 (2006) Abstract; Full Text
[3] Targets of genome copy number reduction in primary breast cancers identified by integrative genomics: W. Chen, et al.; Genes Chromosomes Cancer 46, 288 (2007) Abstract
General Information
RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells.
General Literature References
Tumor suppressor activity of RUNX3: S.C. Bae & J.K. Choi; Oncogene 23, 4336 (2004) Abstract
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis: T. Yano, et al.; Mol. Cell. Biol. 26, 4474 (2006) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-803-319 Revised 24-Apr-08
Monoclonal Antibody to RUNX3 (human) (R3-5G4)
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SYNONYMS anti-Runt-related Transcription Factor 3 (human) MAb (R3-5G4)
anti-CBF-α3 (human) MAb (R3-5G4)
anti-Core-binding Factor α3 Subunit (human) MAb (R3-5G4)
anti-AML-2 (human) MAb (R3-5G4)
anti-Acute Myeloid Leukemia 2 Protein (human) MAb (R3-5G4)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Transcription Factors Other Products
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ALX-803-319-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: R3-5G4
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300).
SPECIFICITY: Recognizes human RUNX3. Weakly cross-reacts with mouse RUNX3.
APPLICATION: Immunoprecipitation
Western Blot (0.2µg/ml (see [1]))
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
[1] RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization: K. Ito, et al.; Cancer Res. 65, 7743 (2005) Abstract; Full Text
General Information
RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells.
General Literature References
Tumor suppressor activity of RUNX3: S.C. Bae & J.K. Choi; Oncogene 23, 4336 (2004) Abstract
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer: Q.C. Lau, et al.; Cancer Res. 66, 6512 (2006) Abstract; Full Text
The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis: T. Yano, et al.; Mol. Cell. Biol. 26, 4474 (2006) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-803-320 Revised 24-Apr-08
Monoclonal Antibody to RUNX3 (R3-1E10)
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SYNONYMS anti-Runt-related Transcription Factor 3 MAb (R3-1E10)
anti-CBF-α3 MAb (R3-1E10)
anti-Core-binding Factor α3 Subunit MAb (R3-1E10)
anti-AML-2 MAb (R3-1E10)
anti-Acute Myeloid Leukemia 2 Protein MAb (R3-1E10)
PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Transcription Factors Other Products
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ALX-803-320-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: R3-1E10
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human RUNX3 (runt-related transcription factor 3) (aa 191-300).
SPECIFICITY: Recognizes human and mouse RUNX3.
APPLICATION: Immunohistochemistry (paraffin sections (2µg/ml) (see [1]))
Western Blot (0.2µg/ml (see [1]))
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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Product Specific Literature References
[1] The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis: T. Yano, et al.; Mol. Cell. Biol. 26, 4474 (2006) Abstract; Full Text
General Information
RUNX (Runt-related transcription factor) family members play important roles in normal developmental processes and carcinogenesis. Of the three known RUNX family members, the ubiquitously expressed RUNX3 is involved in neurogenesis, T cell differentiation, tumorigenesis and is a component of the TGF-β induced tumor suppressor pathway. In gastric cancer cells, RUNX3 induces cell cycle arrest and apoptosis through upregulation of Bim, a proapoptotic BH3-only protein. In addition, RUNX3 is frequently inactivated in gastric cancer cells.
General Literature References
Tumor suppressor activity of RUNX3: S.C. Bae & J.K. Choi; Oncogene 23, 4336 (2004) Abstract
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer: Q.C. Lau, et al.; Cancer Res. 66, 6512 (2006) Abstract; Full Text
Further Categories Containing This Product:
Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-804-645 Revised 05-Mar-07
Monoclonal Antibody to TRIP-Br1 (TB1-27/2)
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SYNONYMS anti-SERTA Domain-containing Protein 1 MAb (TB1-27/2)
anti-SEI-1 MAb (TB1-27/2)
anti-CDK4-binding Protein p34SEI1 MAb (TB1-27/2)
anti-Transcriptional Regulator Interacting with the PHD-bromodomain 1 MAb (TB1-27/2)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDKs & Cyclins Other Products
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ALX-804-645-C050   50 µg 240.00 USD Add To Cart
ALX-804-645-C100   100 µg 360.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Pig
Monkey
CLONE: TB1-27/2
ISOTYPE: Mouse IgG2a.
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 27-42 (D27PGHAAVAQAPPAVAS42) of human TRIP-Br1 [SEI-1].
SPECIFICITY: Recognizes human, mouse, pig and monkey TRIP-Br1.
APPLICATION: Immunohistochemistry (1:200)
Immunoprecipitation
Western Blot (1:1’000-1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
Exploiting the TRIP-Br family of cell cycle regulatory proteins as chemotherapeutic drug targets in human cancer: Z.J. Zang, et al.; (ahead of print), (2007)
General Information
TRIP-Br1 [SEI-1] functions as physiological integrator of transcriptional regulatory signals at E2F-responsive promoters to ensure proper execution of E2F-dependent cell cycle progression. TRIP-Br1 was recently defined as an oncogene.
General Literature References
RBT1, a novel transcriptional co-activator, binds the second subunit of replication protein A: J.M. Cho, et al.; Nucl. Acids Res. 28, 3478 (2000) Abstract; Full Text
TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1: S.I. Hsu, et al.; EMBO J. 20, 2273 (2001) Abstract; Full Text
The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus: S. Calgaro, et al.; Genetics 160, 547 (2002) Abstract; Full Text
Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP: T. Hirose, et al.; Int. J. Mol. Med. 11, 705 (2003) Abstract
TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability: K.G. Sim, et al.; Cell Cycle 3, 1296 (2004) Abstract
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner: J. Li, et al.; Biochemistry 43, 4394 (2004) Abstract
Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitis: K. Ogawa, et al.; Int. Arch. Allergy Immunol. 134 Suppl 1, 2 (2004) Abstract
Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A): J. Li, et al.; Biochemistry 44, 13246 (2005) Abstract
SEI family of nuclear factors regulates p53-dependent transcriptional activation: R. Watanabe-Fukunaga, et al.; Genes Cells 10, 851 (2005) Abstract; Full Text
CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation: R. Hayashi, et al.; J. Biol. Chem. 281, 35633 (2006) Abstract; Full Text
Further Categories Containing This Product:
Transcription Regulators Other Products • Monoclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-210-910 Revised 29-Feb-08
Polyclonal Antibody to CYLD (human) (AF888)
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SYNONYMS anti-Cylindromatosis Tumor Suppressor Protein (human) PAb (AF888)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Other Products
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ALX-210-910-C050   50 µg 195.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.45mg/ml
PURITY DETAIL: Epitope-affinity purified.
FORMULATION: Liquid. In PBS containing 1% BSA and 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 56-70 (G56HSRIPSAKGKKNQI70) of human CYLD (cylindromatosis tumor suppressor protein).
SPECIFICITY: Recognizes human CYLD. Detects a band of ~120kDa by Western blot.
APPLICATION: Immunocytochemistry (on transfected cells; 1:200)
Western Blot (on transfected cells; 1:3'000).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
The tumor suppressor CYLD Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7: H. Yoshida, et al.; J. Biol. Chem. 280, 41111 (2005) Abstract; Full Text
General Information
Cylindromas are benign adnexal skin tumors caused by germ line mutations in the CYLD gene. In most cases the second wild type allele is lost in tumor tissue suggesting that CYLD functions as tumor-suppressor. CYLD is a protein of 956 amino acids harboring a functional deubiquitinating domain at the C-terminal end. CYLD was shown to interact with TRAF2, NEMO and TRIP (Trompouki et al.; Brummelkamp et al.; Kovalenko et al.; Regamey et al.). Furthermore, CYLD is a negative regulator of NF-κB activation mediated by TNF family members and IL-1β. Downregulation of NF-κB activity depends on the deubiquitinating activity of CYLD which removes lysine-63 linked ubiquitin chains from target proteins. These findings indicate that cylindromas arise through constitutive NF-κB activation leading to hyperproliferation and tumor growth.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members: E. Trompouki, et al.; Nature 424, 793 (2003) Abstract
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB: T.R. Brummelkamp, et al.; Nature 424, 797 (2003) Abstract
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination: A. Kovalenko, et al.; Nature 424, 801 (2003) Abstract
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor: A. Regamey, et al.; J. Exp. Med. 198, 1959 (2003) Abstract
Further Categories Containing This Product:
Deubiquitination Other Products • Polyclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-215-062 Revised 16-Jul-08 New product
Polyclonal Antibody to Rho-related BTB Domain-containing Protein 2
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SYNONYMS anti-RhoBTB2/DBC2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Rho / Related Products
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ALX-215-062-C050   50 µg 140.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Affinity purified using the immunogenic peptide.
FORMULATION: Liquid. In PBS containing 0.1% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to the conserved human Rho-related BTB domain-containing protein 2 amino acids 673-687 (KEEDHYQRARKEREK) with an N-terminal C-residue.
SPECIFICITY: Recognizes human, mouse, rat, chicken and zebrafish Rho-related BTB domain-containing protein 2.
APPLICATION: Immunocytochemistry (1:40)
Western Blot (1:200)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Images
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Product Specific Literature References
RhoBTB2 (DBC2) is a mitotic E2F1 target gene with a novel role in apoptosis: S.N. Freeman, et al.; J. Biol. Chem. 283, 2353 (2008) Abstract; Full Text
Further Categories Containing This Product:
Polyclonal Antibodies • Tumor Suppressors / Related Products
 
 
ALX-201-203 Revised 23-Jul-07
Von Hippel-Lindau Disease Tumor Suppressor (β-domain) (human) (recombinant) (His)
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SYNONYMS VHL Disease Tumor Suppressor (β-domain) (human) (recombinant) (His)
PRODUCT LINE Cancer
PRODUCT CATEGORY Tumor Suppressors / Related Products
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ALX-201-203-C100   100 µg 220.00 USD Add To Cart
Product Specification
MW: ~19.2kDa.
SOURCE/HOST: Produced in E. coli.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS, pH 7.4, containing 2mM EDTA.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Gamma synuclein, a novel heat-shock protein-associated chaperone, stimulates ligand-dependent estrogen receptor alpha signaling and mammary tumorigenesis: Y. Jiang, et al.; Cancer Res. 64, 4539 (2004) Abstract