• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Natural Products for Cancer Research
You are here: Product Lines > Cancer > Natural Products for Cancer Research
 
Toolbar - View Selection
 
 Items 100-184 of 184 Page 2 of 2 Select Page: << 1 2   
ALX-350-081 Revised 30-Jun-08
Microcystin-LF
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-081-C025   25 µg 135.00 USD Add To Cart
ALX-350-081-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C52H71N7O12
MW: 986.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable in solution for at least 4 weeks when stored at -20 °C.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: HIGHLY IRRITANT. VERY TOXIC. MAY BE CARCINOGENIC.
IDENTITY: Identity determined by MS.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Phe substituted in place of Arg. Hydrophobic and believed to be more cell permeable than other microcystins. More toxic than the more hydrophilic analogs such as microcystin-LR and microcystin-LY.
Product Specific Literature References
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
First report of microcystins from a Brazilian isolate of the cyanobacterium Microcystis aeruginosa: S.M.F.O. Azevedo, et al.; J. Appl. Phycology 6, 261 (1994)
Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal toxicosis: L.A. Lawton, et al.; Nat. Toxins 3, 50 (1995) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naive human phage display library: J. McElhiney, et al.; FEMS Microbiol. Lett. 193, 83 (2000) Abstract
Pseudodiarrhoea in zebra mussels Dreissena polymorpha (Pallas) exposed to microcystins: G. Juhel, et al.; J. Exp. Biol. 209, 810 (2006) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Marine Natural Products
 
 
ALX-350-012 Revised 23-Oct-08
Microcystin-LR
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-012-C050   50 µg 24.00 USD Add To Cart
ALX-350-012-C100   100 µg 46.00 USD Add To Cart
ALX-350-012-C500   500 µg 175.00 USD Add To Cart
ALX-350-012-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C49H74N10O12
MW: 995.2
CAS NUMBER: 101043-37-2
RTECS: GT2810000
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in 100% ethanol, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.

Product Description
Heptapeptide ester hepatotoxin. Tumor promoter. Equally potent and selective inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). PP2B is less sensitive and PP2C is not inhibited up to 4µM. Useful for affinity-purification of PP2A. The product is not cell permeable except in liver cells, which appear to have a functional uptake system. Has no effect on protein kinases. Less toxic than the more hydrophobic analogs microcystin-LY, -LW and -LF. Frequently contaminates fresh-water lakes and ponds. Causes livestock poisonings. Ozonation did lead to complete loss of toxicity and toxins from contaminated samples.
Product Specific Literature References
Structural studies on cyanoginosins-LR, -YR, -YA, and -YM, peptide toxins from Microcystis aeruginosa: D.P. Botes, et al.; JCS Perkin Trans. I, 2747 (1985)
Nodularin, microcystin, and the configuration of Adda: K.L. Rinehart, et al.; JACS 110, 8557 (1988)
Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases: R.E. Honkanen, et al.; J. Biol. Chem. 265, 19401 (1990) Abstract; Full Text
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants: C. MacKintosh, et al.; FEBS Lett. 264, 187 (1990) Abstract
Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase: G.D. Amick, et al.; Biochem. J. 287, 1019 (1992) Abstract
Evidence for the regulation of exocytic transport by protein phosphorylation: H.W. Davidson, et al.; J. Cell. Biol. 116, 1343 (1992) Abstract
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR: R. Nishiwaki-Matsushima, et al.; J. Cancer Res. Clin. Oncol. 118, 420 (1992) Abstract
Two significant aspects of microcystin-LR: specific binding and liver specificity: R. Nishiwaki, et al.; Cancer Lett. 83, 283 (1994) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Unique features of the okadaic acid activity class of tumor promoters: H. Fujiki & M. Suganuma; J. Cancer Res. Clin. Oncol. 125, 150 (1999), Review Abstract
The toxicology of microcystin-LR: occurrence, toxicokinetics, toxicodynamics, diagnosis and treatment: K. Bischoff; Vet. Hum. Toxicol. 43, 294 (2001), Review Abstract
Negative regulation of ERK and Elk by protein kinase B modulates c-Fos transcription: I. Galetic, et al.; J. Biol. Chem. 278, 4416 (2003) Abstract; Full Text
Decrease in toxicity of microcystins LA and LR in drinking water by ozonation: S. Brooke, et al.; Toxicon. 48, 1054 (2006) Abstract
Mitochondria a key role in microcystin-LR kidney intoxication: R. La-Salete, et al.; J. Appl. Toxicol. 28, 55 (2008) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Natural Products - Other Tumor Promoters • Carcinogens & Tumor Promoters Other Products • Marine Natural Products
 
 
ALX-350-080 Revised 11-Jan-08
Microcystin-LW
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-080-C025   25 µg 135.00 USD Add To Cart
ALX-350-080-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C54H72N8O12
MW: 1025.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in 100% methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. HIGHLY IRRITANT. VERY TOXIC.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Trp substituted in place of Arg. Hydrophobic and believed to be more cell permeable than other microcystins. May prove useful in biochemical studies in intact cells. Microcystin-LW has a characteristically different absorption spectrum compared to other microcystins, making it a useful reference compound for HPLC analysis. The Trp confers an absorption maximum at 222nm, whereas most microcystins have a characteristic maximum at 239nm.
Product Specific Literature References
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal toxicosis: L.A. Lawton, et al.; Nat. Toxins 3, 50 (1995) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Detection and quantification of microcystins (cyanobacterial hepatotoxins) with recombinant antibody fragments isolated from a naive human phage display library: J. McElhiney, et al.; FEMS Microbiol. Lett. 193, 83 (2000) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Marine Natural Products
 
 
ALX-350-148 Revised 06-Jun-08
Microcystin-LY
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-148-C025   25 µg 135.00 USD Add To Cart
ALX-350-148-C100   100 µg 390.00 USD Add To Cart
Product Specification
FORMULA: C52H71N7O13
MW: 1002.2
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Whitish film adhered to inside of the vial.
SOLUBILITY: Soluble in 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at -20°C. Unstable at pH>7.7.
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.
IDENTITY: Identity determined by MS.

Product Description
Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Arg. Its toxicity is intermediate between the more toxic microcystin-LF and the less toxic microcystin-LR.
Product Specific Literature References
The effects of single L-amino acid substitutions on the lethal potencies of the microcystins: R.D. Stoner, et al.; Toxicon 27, 825 (1989)
Identification and characterization of microcystin-LY from Microcystis aeruginosa (strain 298): S. Rudolph-Bohner, et al.; Biol. Chem. Hoppe Seyler 374, 635 (1993) Abstract
Comparative toxicity of four microcystins of different hydrophobicities to the protozoan, Tetrahymena pyriformis: C.J. Ward & G.A. Codd; J. Appl. Microbiol. 86, 874 (1999) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Marine Natural Products
 
 
ALX-350-043 Revised 06-Jun-08
Microcystin-RR
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-043-C050   50 µg 70.00 USD Add To Cart
ALX-350-043-C100   100 µg 125.00 USD Add To Cart
ALX-350-043-C250   250 µg 240.00 USD Add To Cart
ALX-350-043-C500   500 µg 470.00 USD Add To Cart
ALX-350-043-M001   1 mg 850.00 USD Add To Cart
Product Specification
FORMULA: C49H75N13O12
MW: 1038.2
CAS NUMBER: 111755-37-4
SOURCE/HOST: Isolated from Microcystis aeruginosa.
PURITY: ≥95% (HPLC)
APPEARANCE: Clear to whitish film adhered to inside of vial.
SOLUBILITY: Soluble in 80% aqueous methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap.
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC. HIGHLY IRRITANT.
IDENTITY: Identity determined by MS.

Product Description
Arg-Arg analog of microcystin-LR (Prod. No. ALX-350-012). Hepatotoxic, although found to be up to 10-fold less toxic than microcystin-LR on i.p. injection in mice. Potent inhibitor of protein phosphatase 2A (PP2A).
Product Specific Literature References
The structure of a cyclic peptide toxin, cyanogenosin-RR from Microcystis aeruginosa: P. Painuly, et al.; THL 29, 11 (1988)
Toxicity and toxins of natural blooms and isolated strains of Microcystis spp. (Cyanobacteria) and improved procedure for purification of cultures: M. Shirai, et al.; Appl. Environ. Microbiol. 57, 1241 (1991) Abstract
Inhibition of protein phosphatases activates glucose-6-phosphatase in isolated rat hepatocytes: S. Claeyssens, et al.; FEBS Lett. 315, 7 (1993) Abstract
Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters: L.A. Lawton, et al.; Analyst 119, 1525 (1994) Abstract
Determination of some physicochemical parameters of microcystins (cyanobacterial toxins) and trace level analysis in environmental samples using liquid chromatography: C. Rivasseau, et al.; J. Chromatogr. A 799, 155 (1998) Abstract
Physiological and biochemical analyses of microcystin-RR toxicity to the cyanobacterium Synechococcus elongatus: Z.Q. Hu, et al.; Environ. Toxicol. 19, 571 (2004) Abstract
Microcystin-RR-induced accumulation of reactive oxygen species and alteration of antioxidant systems in tobacco BY-2 cells: L. Yin, et al.; Toxicon. 46, 507 (2005) Abstract
Related Products
Further Categories Containing This Product:
Other Toxins • Marine Natural Products • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-850-319 Revised 30-Sep-08
Microcystins (Adda specific) ELISA Kit
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-319-KI01   1 Kit 575.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.1ng/ml (range 0.15 to 5ng/ml)
QUANTITY: 96 wells (~80 tests)
APPLICATION: For the quantitative and sensitive congener-independent detection of microcystins and nodularin in water samples.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Polyclonal antibody prepared against the Adda moiety binds to microcystins and nodularins, allowing the congener-independent determination of these toxins and many of its congeners, and does not cross-react with other non-related toxins or compounds. No pre-sample preparation required. Total time for measurement is less than 2.5 hours. Enables simultaneous measurement of multiple samples at reasonable costs. Patented technology.
U.S. Patent No. 6,967,240
Worldwide Patent PCT WO 01/18059 A2
Product Specific Literature References
Congener-independent immunoassay for microcystins and nodularins: W.J. Fischer, et al.; Environ. Sci. Technol. 35, 4849 (2001) Abstract
A review of analytical methods for assessing the public health risk from microcystin in the aquatic environment: P.R. Hawkins, et al.; J. Water Supply 54, 509 (2005)
General Information
Microcystins are extremely toxic compounds produced by cyanobacteria (blue-green algae), belonging to species of Microcystis, Oscillatoria, Anabaena and Nostoc. The contamination of drinking water or water of recreational areas can cause severe health problems to exposed humans and animals. Microcystins possess a cyclic heptapeptide structure of the general composition cyclo(-D-Ala-L-X-D-erythro-β-methylisoAsp-L-Y-Adda-D-iso-Glu-N-methyldehydroAla), where Adda is the unusual C20 aa 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid and X and Y are variable L-aa.
MANUFACTURER Manufactured by Abraxis LLC.
Related Products
Further Categories Containing This Product:
ELISA & EIA Kits • Marine Natural Products
 
 
ALX-850-324 Revised 30-Sep-08
Microcystins-DM ELISA Kit
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Microcystins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-324-KI01   1 Kit 575.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.1ng/ml (range 0.15 to 5ng/ml)
QUANTITY: 96 wells (~80 tests)
APPLICATION: For the quantitative and sensitive detection of microcystins and nodularin in water samples.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
No pre-sample preparation required. Total time for measurement is less than 2.5 hours. Enables simultaneous measurement of multiple samples at reasonable costs. Patented technology.
U.S. Patent No. 6,967,240
Worldwide Patent PCT WO 01/18059 A2
Product Specific Literature References
Development of a direct competitive microcystin immunoassay of broad specificity: M.G. Weller, et al.; Anal. Sci. 17, 1445 (2001) Abstract
General Information
Microcystins are extremely toxic compounds produced by cyanobacteria (blue-green algae), belonging to species of Microcystis, Oscillatoria, Anabaena and Nostoc. The contamination of drinking water or water of recreational areas can cause severe health problems to exposed humans and animals. Microcystins possess a cyclic heptapeptide structure of the general composition cyclo(-D-Ala-L-X-D-erythro-β-methylisoAsp-L-Y-Adda-D-iso-Glu-N-methyldehydroAla), where Adda is the unusual C20 aa 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid and X and Y are variable L-aa.
MANUFACTURER Manufactured by Abraxis LLC.
Related Products