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Natural Products for Neurological Research
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ALX-350-326 Revised 29-May-07
Agelongine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-326-M001   1 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C13H11BrN2O4
MW: 339.1
CAS NUMBER: 163564-84-9
SOURCE/HOST: Isolated from the sponge Agelas longissima.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Alkaloid exhibiting antagonistic activity on serotonin receptors.
Product Specific Literature References
A novel bromopyrrole alkaloid from the sponge agelas longissima with antiserotonergic activity: F. Cafieri, et al.; Bioorg. Med. Chem. Lett. 5, 799 (1995)
Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent: L. Meijer, et al.; Chem. Biol. 7, 51 (2000) Abstract
Further Categories Containing This Product:
Alkaloids • Serotonergics & Serotonin Receptors / Related Products • Marine Natural Products
 
 
ALX-350-112 Revised 29-Nov-07
Anabasine . hydrochloride
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SYNONYMS 3-(2-Piperidinyl)pyridine
2-(3-Pyridyl)piperidine
Neonicotine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-350-112-M025   25 mg 20.00 USD Add To Cart
ALX-350-112-M100   100 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C10H14N2 . HCl
MW: 162.2 . 36.5
CAS NUMBER: 15251-47-5
MERCK INDEX: 14: 619
SOURCE/HOST: Isolated from Anabasis aphylla.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in alcohol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Tobacco alkaloid. Potent nicotinic acetylcholine receptor agonist. Insecticide.
Product Specific Literature References
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro: R.L. Barbieri, et al.; J. Clin. Invest. 77, 1727 (1986) Abstract
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy: P. Jacob, 3rd, et al.; Cancer Epidemiol. Biomarkers Prev. 11, 1668 (2002) Abstract
Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia: J. Mastropaolo, et al.; Behav. Brain Res. 153, 419 (2004) Abstract
Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry: X. Xu, et al.; Clin. Chem. 50, 2323 (2004) Abstract
Anabasine toxicity from a topical folk remedy: N.G. Murphy, et al.; Clin. Pediatr. (Phila) 45, 669 (2006) Abstract
Further Categories Containing This Product:
Alkaloids • Acetylcholine Receptors (Nicotinic) / Related Products • Pesticides / Related Products
 
 
ALX-550-322 Revised 11-Nov-08
Caffeine
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SYNONYMS 1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-550-322-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C8H10N4O2
MW: 194.2
CAS NUMBER: 58-08-2
MERCK INDEX: 14: 1636
SOURCE/HOST: Found in tea leaves, coffee beans, cocoa beans, maté leaves, guarana paste and kola nuts.
PURITY: ≥99%
APPEARANCE: White to colorless powder.
SOLUBILITY: Soluble in chloroform, 100% alcohol or hot water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: HARMFUL.
IDENTITY: Identity determined by NIR.

Product Description
CNS stimulant. Blocks adenosine A1 and A2A receptors. cAMP phosphodiesterase inhibitor. Interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle. Prevents apoptosis and cell cycle effects induced by various chemicals. Inhibits cellular DNA repair mechanisms. Anti-inflammatory.
Product Specific Literature References
Analogues of caffeine and theophylline: effect of structural alterations on affinity at adenosine receptors: J.W. Daly, et al.; J. Med. Chem. 29, 1305 (1986) Abstract
Caffeine as an analgesic adjuvant: a review of pharmacology and mechanisms of action: J. Sawynok & T.L. Yaksh; Pharmacol. Rev. 45, 43 (1993) Abstract
Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells: F. Traganos, et al.; Cancer Res. 53, 4613 (1993) Abstract
Multiple effects of caffeine on calcium current in rat ventricular myocytes: I. Zahradnik & P. Palade; Pfluegers Arch. 424, 129 (1993) Abstract
Acute effects of caffeine on arterial stiffness, wave reflections, and central aortic pressures: T.G. Papaioannou, et al.; Am. J. Hypertens. 18, 129 (2005), (Review) Abstract
Caffeine and the dopaminergic system: O. Cauli & M. Morelli; Behav. Pharmacol. 16, 63 (2005), (Review) Abstract
Immunomodulatory effects of caffeine: friend or foe: L. A. Horrigan, et al.; Pharmacol. Ther. 111, 877 (2006), (Review) Abstract
Novel neuroprotection by caffeine and adenosine A(2A) receptor antagonists in animal models of Parkinson’s disease: A. Kalda, et al.; J. Neurol. Sci. 248, 9 (2006), (Review) Abstract
The enigmatic effects of caffeine in cell cycle and cancer: A. M. & Bode and Z. Dong; Cancer Lett. 247, 26 (2007), (Review) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Ca2+ Modulators • Natural Products - Chemopreventive Agents • Neuroactive Agents Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • DNA Repair Other Products • Alkaloids • Other Natural Products - DNA Regulation / Transcription • Natural Products for Cell Cycle Research • Phosphodiesterases / Related Products
 
 
ALX-430-152 Revised 03-Apr-08
Cannabidiol
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SYNONYMS CBD
2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-430-152-M001   1 mg Inquire
ALX-430-152-M005   5 mg Inquire
Product Specification
FORMULA: C21H30O2
MW: 314.5
CAS NUMBER: 13956-29-1
MERCK INDEX: 14: 1747
RTECS: VH1600000
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Non-psychotropic, anticonvulsive and neuroprotective in vivo. Shown to be a weak CB1 receptor antagonist and inhibitor of anandamide uptake (IC50=3.35mM and 27.5mM, respectively). Weak agonist of TRPV1 (EC50=3.5mM).
Product Specific Literature References
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants: A.J. Hampson, et al.; PNAS 95, 8268 (1998) Abstract; Full Text
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: A.M. Malfait, et al.; PNAS 97, 9561 (2000) Abstract; Full Text
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite: A.B. El-Remessy, et al.; Am. J. Pathol. 163, 1997 (2003) Abstract; Full Text
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines: P. Massi, et al.; J. Pharmacol. Exp. Ther. 308, 838 (2004) Abstract; Full Text
Effects of cannabidiol (CBD) on regional cerebral blood flow: J.A. Crippa, et al.; Neuropsychopharmacology 29, 417 (2004) Abstract; Full Text
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression: E.J. Carrier, et al.; PNAS 103, 7895 (2006) Abstract; Full Text
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells: E. Del Giudice, et al.; J. Leukoc. Biol. 81, 1512 (2007) Abstract; Full Text
Further Categories Containing This Product:
Anandamide Uptake Inhibitors • Cannabinoid Receptor Agonists & Antagonists / Related Products • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-430-154 Revised 03-Apr-08
Cannabigerol
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SYNONYMS CBG
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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not sold in USA
Product Specification
FORMULA: C21H32O2
MW: 316.5
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Analog of cannabidiol (Prod. No. ALX-430-152) with similar pharmacological properties.
Product Specific Literature References
Cannabigerol monomethyl ether, a new component of hemp: T. Yamauchi, et al.; Chem. Pharm. Bull 16, 1164 (1968) Abstract
In vitro metabolism of cannabigerol in several mammalian species: D.J. Harvey and N.K. Brown; Biomed. Environ. Mass Spectrom. 19, 545 (1990) Abstract
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-550-066 Revised 03-Apr-08
(E)-Capsaicin
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SYNONYMS (E)-N-([4-Hydroxy-3-methoxyphenyl]methyl)-8-methyl-6-nonenamide
trans-8-Methyl-N-vanillyl-6-nonenamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-550-066-M100   100 mg 48.00 USD Add To Cart
Product Specification
FORMULA: C18H27NO3
MW: 305.4
CAS NUMBER: 404-86-4
MERCK INDEX: 14: 1768
RTECS: RA8530000
SOURCE/HOST: Isolated from Capsicum fruit.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol or chloroform; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: POTENT NEUROTOXIN. IRRITANT.

Product Description
Constituent of cayenne pepper. Powerful excitant of peripheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Elicits pain by activating TRPV1. Chemoprotective against some chemical carcinogens and mutagens. Reversibly inhibits aggregation of platelets.
Product Specific Literature References
Capsaicin: identification, nomenclature, and pharmacotherapy: G.A. Cordell & O.E. Araujo; Ann. Pharmacother. 27, 330 (1993), (Review) Abstract
Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential: Y. J. Surh & S. S. Lee; Life Sci. 56, 1845 (1995), (Review) Abstract
Topical capsaicin. A review of its pharmacological properties and therapeutic potential in post-herpetic neuralgia, diabetic neuropathy and osteoarthritis: C. Rains & H. M. Bryson; Drugs Aging 7, 317 (1995), (Review) Abstract
Peppers and pain. The promise of capsaicin: B. M. Fusco & M. Giacovazzo; Drugs 53, 909 (1997), (Review) Abstract
Capsaicin sensitive-sensory nerves and blood pressure regulation: P. Vaishnava & D.H. Wang; Curr. Med. Chem. Cardiovasc. Hematol. Agents 1, 177 (2003), (Review) Abstract
Forty years in capsaicin research for sensory pharmacology and physiology: J. Szolcsanyi; Neuropeptides 38, 377 (2004), (Review) Abstract
Further Categories Containing This Product:
Natural Products for Neurological Research • TRPV1 Agonists and Antagonists / Related Products • Active Substances from Fruit and Vegetables • Alkaloids
 
 
ALX-350-052 Revised 17-Nov-08
Dihydrocapsaicin
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SYNONYMS 8-Methyl-N-vanillylnonanamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-350-052-M010   10 mg 28.00 USD Add To Cart
ALX-350-052-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C18H29NO3
MW: 307.4
CAS NUMBER: 19408-84-5
RTECS: RA5998000
SOURCE/HOST: Isolated from Capsicum fruit.
PURITY: ≥85%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT. POTENT NEUROTOXIN.

Product Description
Dihydro-analog and congener of capsaicin (Prod. No. ALX-550-066) in chili peppers (Capsicum). Like capsaicin it is irritant. Dihydrocapsaicin accounts for about 22% of the total capsaicinoids mixture and has about the same pungency as capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic.
Product Specific Literature References
The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells: T. Lawson & P. Gannett; Cancer Lett. 48, 109 (1989) Abstract
Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep: R. Ramirez-Romero, et al.; Regul. Pept. 91, 97 (2000) Abstract
Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II): S. Singh, et al.; Cancer Lett. 169, 139 (2001) Abstract
Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry: A. Garces-Claver, et al.; J. Agric. Food Chem. 54, 9303 (2006) Abstract
Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids: K.D. Ahuja, et al.; J. Agric. Food Chem. 54, 6436 (2006) Abstract
General Literature References
Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin,induces autophagy in human cancer cells in a catalase-regulated manner: S.H. Oh, et al.; Autophagy 4, 1009 (2008) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products for Neurological Research • Autophagy Other Products • Alkaloids
 
 
ALX-350-353 Revised 16-Jun-08
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
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ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
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Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • MAPK Pathway Activators • Tyrosine Kinase Inhibitors • Natural Products - Antioxidants • Natural Products - Protein Kinase Inhibitors • Natural Products for Neurological Research • Natural Products - Apoptosis Inducers & Inhibitors • Analgesic / Anti-nociceptive Agents / Related Products • Phenolic Acids
 
 
ALX-106-028 Revised 03-Apr-08
D-Cycloserine
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SYNONYMS R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-028-M050   50 mg 20.00 USD Add To Cart
ALX-106-028-M250   250 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 68-41-7
RTECS: NY2975000
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description