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ALX-210-470
Revised 30-Jul-07
Polyclonal Antibody to ANGPTL4 (Coiled-coil Domain) (human)
SYNONYMS
anti-Angiopoietin-like Protein 4 (Coiled-coil Domain) (human) PAb
anti-FIAF (Coiled-coil Domain) (human) PAb
anti-Fasting-induced Adipose Factor (Coiled-coil Domain) (human) PAb
anti-HFARP (Coiled-coil Domain) (human) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (Coiled-coil Domain) (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-470-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS, pH 7.4. Contains no preservatives.
PURITY DETAIL:
Purified IgG.
IMMUNOGEN:
Coiled-coil domain of recombinant human ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes the coiled-coil domain of human ANGPTL4. Weakly cross-reacts with human ANGPTL2 (coiled-coil domain), ANGPTL3 and ANGPTL5 (coiled-coil domain).
CROSSREACTIVITY PROTEINS:
ANGPTL2 (CCD) (weak); ANGPTL3 (weak); ANGPTL5 (CCD) (weak)
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-469
Revised 30-Jul-07
Polyclonal Antibody to ANGPTL4 (Fibrinogen-like Domain) (human)
SYNONYMS
anti-Angiopoietin-like Protein 4 (Fibrinogen-like Domain) (human) PAb
anti-FIAF (Fibrinogen-like Domain) (human) PAb
anti-Fasting-induced Adipose Factor (Fibrinogen-like Domain) (human) PAb
anti-HFARP (Fibrinogen-like Domain) (human) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (Fibrinogen-like Domain) (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-469-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS, pH 7.4. Contains no preservatives.
PURITY DETAIL:
Purified IgG.
IMMUNOGEN:
Fibrinogen-like domain of recombinant human ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes the fibrinogen-like domain of human ANGPTL4. Weakly cross-reacts with human ANGPTL3 (fibrinogen-like domain), ANGPTL5 (fibrinogen-like domain), ANGPTL6 (fibrinogen-like domain) and ANGPTL6. Does not cross-react with ANGPTL4 ((Coiled-coil domain)) or other ANGPTL family proteins.
CROSSREACTIVITY PROTEINS:
ANGPTL3 (FLD) (weak), ANGPTL5 (FLD) (weak), ANGPTL6 (FLD) (weak), ANGPTL6 (weak)
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-439
Revised 23-Jul-08
Polyclonal Antibody to ANGPTL4 (human)
SYNONYMS
anti-Angiopoietin-like Protein 4 (human) PAb
anti-FIAF (human) PAb
anti-Fasting-induced Adipose Factor (human) PAb
anti-HFARP (human) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-439-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS, pH 7.4. Contains no preservatives.
PURITY DETAIL:
Purified IgG.
IMMUNOGEN:
Recombinant human ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes human ANGPTL4.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Prod. No.
ALX-201-338
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Related Products
ALX-201-338
ANGPTL4 (human) (recombinant)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-475
Revised 26-Oct-07
Polyclonal Antibody to ANGPTL4 (mouse)
SYNONYMS
anti-Angiopoietin-like Protein 4 (mouse) PAb
anti-FIAF (mouse) PAb
anti-Fasting-induced Adipose Factor (mouse) PAb
anti-HFARP (mouse) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (mouse) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-475-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS, pH 7.4. Contains no preservatives.
PURITY DETAIL:
Purified IgG.
IMMUNOGEN:
Recombinant mouse ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes mouse ANGPTL4.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
POSITIVE CONTROL:
Prod. No.
ALX-201-338
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Related Products
ALX-201-338
ANGPTL4 (human) (recombinant)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-360
Revised 29-Sep-05
Polyclonal Antibody to ANGPTL4 (rat)
SYNONYMS
anti-Angiopoietin-like Protein 4 (rat) PAb
anti-FIAF (rat) PAb
anti-Fasting-induced Adipose Factor (rat) PAb
anti-HFARP (rat) PAb
anti-Hepatic Fibrinogen/Angiopoietin-related Protein (rat) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-360-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Epitope-affinity purified.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 80-94 (C
80
QGPKGKDAPFKDSE
94
) of mouse ANGPTL4 (angiopoietin-like protein 4).
SPECIFICITY:
Recognizes rat ANGPTL4. Detects a band of ~50kDa by Western blot.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-156-004
.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene
:
S. Kersten, et al.; J. Biol. Chem.
275
, 28488 (2000)
Abstract
;
Full Text
General Information
Adipose tissue is an energy reserve in animals and, in nondomestic species, is strictly regulated. Adipose cells produce and secrete numerous physiologically important proteins that help regulate whole body metabolism, such as leptin and adiponectin. Fasting causes significant changes in nutrient metabolism and many of these changes are controlled by transcription factors that regulate rate-limiting enzymes. An important transcription factor that mediates metabolic processes induced by fasting is peroxisome proliferator-activated receptor α (PPARα). PPARα has been reported to target a gene encoding the secreted protein ANGPTL4 (angiopoietin-like protein 4; FIAF; fasting-induced adipose factor). ANGPTL4 is expressed predominantly in adipose tissue and is strongly upregulated in white adipose tissue and the liver under fasting conditions. Initial studies suggest that ANGPTL4 represents an endocrine signal helping to regulate metabolism, especially under fasting conditions.
Related Products
ALX-156-004
Blocking Peptide for PAb to ANGPTL4 (Prod. No.
ALX-210-360
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-473
Revised 09-Aug-07
Polyclonal Antibody to ANGPTL5 (Coiled-coil Domain) (human)
SYNONYMS
anti-Angiopoietin-like Protein 5 (Coiled-coil Domain) (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-473-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY:
Liquid. In PBS, pH 7.4. Contains no preservatives.
PURITY DETAIL:
Purified IgG.
IMMUNOGEN:
Coiled-coil domain of recombinant human ANGPTL5 (angiopoietin-like protein 5).
SPECIFICITY:
Recognizes the coiled-coil domain of human ANGPTL5.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature). Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-430
Revised 24-Jul-06
Polyclonal Antibody to ANGPTL6 (human)
SYNONYMS
anti-Angiopoietin-like Protein 6 (human) PAb
anti-AGF (human) PAb
anti-Angiopoietin-related Growth Factor (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-430-C100
100 µg
290.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Synthetic peptide corresponding to aa 114-130 (L
114
QHEAGPGAGPGADLGA
130
) of human ANGPTL6 (angiopoietin-like protein 6; AGF).
SPECIFICITY:
Recognizes human ANGPTL6.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration:
Y. Oike, et al.; PNAS
100
, 9494 (2003)
Abstract
;
Full Text
Angiopoietin-related growth factor (AGF) promotes angiogenesis:
Y. Oike, et al.; Blood
103
, 3760 (2004)
Abstract
;
Full Text
Angiopoietin-related growth factor antagonizes obesity and insulin resistance:
Y. Oike, et al.; Nat. Med.
11
, 400 (2005)
Abstract
Related Products
AG-A0722
ANGPTL6 (human) ELISA Kit
ALX-201-337
ANGPTL6 (human) (recombinant)
ALX-201-394
ANGPTL6 (Fibrinogen-like Domain) (human) (recombinant)
ALX-210-438
Polyclonal Antibody to ANGPTL6 (human)
ALX-804-725
Monoclonal Antibody to ANGPTL6 (human) (Kairos-60)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-438
Revised 08-Dec-06
Polyclonal Antibody to ANGPTL6 (human)
SYNONYMS
anti-Angiopoietin-like Protein 6 (human) PAb
anti-AGF (human) PAb
anti-Angiopoietin-related Growth Factor (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-438-C100
100 µg
310.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human ANGPTL6 (angiopoietin-like protein 6; AGF).
SPECIFICITY:
Recognizes human ANGPTL6.
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature.)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
POSITIVE CONTROL:
Prod. No.
ALX-201-337
Product Images
Please click on thumbnails to enlarge.
General Information
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration:
Y. Oike, et al.; PNAS
100
, 9494 (2003)
Abstract
;
Full Text
Angiopoietin-related growth factor (AGF) promotes angiogenesis:
Y. Oike, et al.; Blood
103
, 3760 (2004)
Abstract
;
Full Text
Angiopoietin-related growth factor antagonizes obesity and insulin resistance:
Y. Oike, et al.; Nat. Med.
11
, 400 (2005)
Abstract
Related Products
AG-A0722
ANGPTL6 (human) ELISA Kit
ALX-201-337
ANGPTL6 (human) (recombinant)
ALX-201-394
ANGPTL6 (Fibrinogen-like Domain) (human) (recombinant)
ALX-210-430
Polyclonal Antibody to ANGPTL6 (human)
ALX-804-725
Monoclonal Antibody to ANGPTL6 (human) (Kairos-60)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-453
Revised 19-Feb-07
Polyclonal Antibody to ANGPTL7 (human)
SYNONYMS
anti-Angiopoietin-like Protein 7 (human) PAb
anti-Cornea-derived Transcript 6 Protein (human) PAb
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-453-C100
100 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Purified IgG.
FORMULATION:
Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human ANGPTL7 (angiopoietin-like protein 7).
SPECIFICITY:
Recognizes human ANGPTL7. Weakly cross-reacts with human ANGPTL3 and ANGPTL4. Does not cross-react with ANGPTL1, ANGPTL2 and ANGPTL6.
CROSSREACTIVITY PROTEINS:
ANGPTL3, ANGPTL4
APPLICATION:
ELISA
(direct and indirect: 1:2’000-1:5’000)
Western Blot
(1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45 kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model [1]. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1 [2]. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine [3].
MANUFACTURER
Manufactured by AdipoGen, Inc.
General Literature References
[1]
The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea:
R. Peek, et al.; J. Biol. Chem.
277
, 686 (2002)
Abstract
;
Full Text
[2]
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells:
C.C. Zhang, et al.; Nat. Med.
12
, 240 (2006)
Abstract
[3]
Comparative integromics on Angiopoietin family members:
Y. Katoh and M. Katoh; Int. J. Mol. Med.
17
, 1145 (2006)
Abstract
Related Products
ALX-804-738
Monoclonal Antibody to ANGPTL7 (human) (Kairos 108-4)
ALX-201-368
ANGPTL7 (human) (recombinant)
ALX-201-395
ANGPTL7 (Fibrinogen-like Domain) (human) (recombinant)
Further Categories Containing This Product:
Polyclonal Antibodies
