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ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-142
Revised 11-Dec-04
Tyrphostin AG 555
SYNONYMS
Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-142-M005
5 mg
25.00 USD
ALX-270-142-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
MW:
322.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-143
Revised 20-Feb-08
Tyrphostin AG 494
SYNONYMS
Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-143-M005
5 mg
25.00 USD
ALX-270-143-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
12
N
2
O
3
MW:
280.3
CAS NUMBER:
133550-35-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Tyrphostin AG 494 blocks Cdk2 activation:
N. Osherov & A. Levitzki; FEBS Lett.
410
, 187 (1997)
Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase:
N. Kleinberger-Doron, et al.; Exp. Cell Res.
241
, 340 (1998)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
•
CDK & Cyclin Inhibitors
ALX-270-144
Revised 07-Dec-04
Tyrphostin AG 835
SYNONYMS
Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-144-M005
5 mg
25.00 USD
ALX-270-144-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-37-5
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-146
Revised 11-Dec-04
Tyrphostin AG 556
SYNONYMS
Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-146-M005
5 mg
25.00 USD
ALX-270-146-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
20
N
2
O
3
MW:
336.4
CAS NUMBER:
133550-41-1
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-160
Revised 27-Sep-07
Castanospermine
SYNONYMS
(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizine
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-160-M010
10 mg
60.00 USD
ALX-270-160-M050
50 mg
180.00 USD
Product Specification
FORMULA:
C
8
H
15
NO
4
MW:
189.2
CAS NUMBER:
79831-76-8
MERCK INDEX:
14:
1896
SOURCE/HOST:
Isolated from
Castanospermum australe
seeds.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Plant alkaloid. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Prevents angiogenesis.
Product Specific Literature References
Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin:
Y.T. Pan, et al.; Biochemistry
22
, 3975 (1983)
Abstract
Glycoproteins: their structure, biosynthesis and possible clinical implications:
H. Schachter; Clin. Biochem.
17
, 3 (1984)
Abstract
The effects of processing inhibitors of N-linked oligosaccharides on the intracellular migration of glycoprotein E2 of mouse hepatitis virus and the maturation of coronavirus particles:
R. Repp, et al.; J. Biol. Chem.
260
, 15873 (1985)
Abstract
;
Full Text
Effects of the anti-inflammatory compounds castanospermine, mannose-6- phosphate and fucoidan on allograft rejection and elicited peritoneal exudates:
M.R. Bartlett, et al.; Immunol. Cell Biol.
72
, 367 (1994)
Abstract
Antiviral activity and metabolism of the castanospermine derivative MDL 28,574, in cells infected with herpes simplex virus type 2:
S.P. Ahmed, et al.; BBRC
208
, 267 (1995)
Abstract
The alpha-glucosidase I inhibitor castanospermine alters endothelial cell glycosylation, prevents angiogenesis, and inhibits tumor growth:
R. Pili, et al.; Cancer Res.
55
, 2920 (1995)
Abstract
Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells:
C. Durrant & S.E. Moore; Biochem. J.
365
, 239 (2002)
Abstract
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents
•
Natural Products for Angiogenesis Research
•
Alkaloids
•
Glycosidases / Related Products
ALX-270-171
Revised 30-Jun-08
Chlorpromazine . hydrochloride
SYNONYMS
2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-171-G001
1 g
22.00 USD
ALX-270-171-G005
5 g
66.00 USD
Product Specification
FORMULA:
C
17
H
19
ClN
2
S . HCl
MW:
318.9 . 36.5
CAS NUMBER:
69-09-0
MERCK INDEX:
14:
2185
RTECS:
SO1750000
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D
2
antagonist. H
1
antagonist. Inhibits TNF-α production. Potent PLA
2
inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity:
H.B. Collier; Clin. Biochem.
7
, 331 (1974)
Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins:
D.R. Marshak, et al.; Biochemistry
24
, 144 (1985)
Abstract
Selective inhibition of group II phospholipase A2 by quercetin:
M. Lindahl & C. Tagesson; Inflammation
17
, 573 (1993)
Abstract
Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge:
M. Palacios, et al.; BBRC
196
, 280 (1993)
Abstract
Protective effect of calmodulin inhibitors against acute cyanide- induced lethality and convulsions in mice:
H. Yamamoto; Toxicol. Lett.
66
, 73 (1993)
Abstract
Pharmacologic inhibitors of tumor necrosis factor production exert differential effects in lethal endotoxemia and in infection with live microorganisms in mice:
M.G. Netea, et al.; J. Infect. Dis.
171
, 393 (1995)
Abstract
Pharmacological regulation of mitochondrial nitric oxide synthase:
A. Boveris, et al.; Methods Enzymol.
359
, 328 (2002)
Abstract
Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine:
S. Lores-Arnaiz, et al.; Arch. Biochem. Biophys.
430
, 170 (2004)
Abstract
Further Categories Containing This Product:
Phosphodiesterases / Related Products
•
TNF-alpha & TNF Receptors Other Products
•
PLA2 Inhibitors
•
Chemopreventive Agents Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Dopaminergics & Dopamine Receptors / Related Products
ALX-270-193
Revised 04-Mar-05
Nimesulide
SYNONYMS
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
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ALX-270-193-G005
5 g
80.00 USD
Product Specification
FORMULA:
C
13
H
12
N
2
O
5
S
MW:
308.3
CAS NUMBER:
51803-78-2
MERCK INDEX:
14:
6548
PURITY:
≥99%
APPEARANCE:
Light tan crystals.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system:
J. Barnett, et al.; Biochim. Biophys. Acta
1209
, 130 (1994)
Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2):
R. Huff, et al.; Inflamm. Res.
44
, S145 (1995)
Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons:
J.L. Johnson, et al.; Arch. Biochem. Biophys.
324
, 26 (1995)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors)
•
Antitumor Agents (Apoptosis Inducers)
•
COX Inhibitors
ALX-270-194
Revised 19-Sep-05
Valeryl salicylate
SYNONYMS
2-Valeryloxybenzoic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
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ALX-270-194-M100
100 mg
51.00 USD
Product Specification
FORMULA:
C
12
H
14
O
4
MW:
222.2
CAS NUMBER:
64206-54-8
PURITY:
≥99%
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol (95mg/ml), methanol, DMSO (43mg/ml) or dimethyl formamide (70mg/ml); also soluble in PBS, pH 7.2 (6mg/ml)). Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Selective inhibitor of cyclooxygenase-1 (COX-1).
Product Specific Literature References
Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid:
D.K. Bhattacharyya, et al.; Arch. Biochem. Biophys.
317
, 19 (1995)
Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons:
J.L. Johnson, et al.; Arch. Biochem. Biophys.
324
, 26 (1995)
Abstract
Further Categories Containing This Product:
COX Inhibitors
ALX-270-196
Revised 12-Sep-05
Niflumic acid
SYNONYMS
Nifluril
2-[[3-(Trifluoromethyl)phenyl]-amino]-3-pyridinecarboxylic acid
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-196-G005
5 g
26.00 USD
Product Specification
FORMULA:
C
13
H
9
F
3
N
2
O
2
MW:
282.2
CAS NUMBER:
4394-00-7
MERCK INDEX:
14:
6531
PURITY:
≥99%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, DMSO or acetonitrile.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
USE/STABILITY:
Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.
Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2).
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system:
J. Barnett, et al.; Biochim. Biophys. Acta
1209
, 130 (1994)
Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons:
J.L. Johnson, et al.; Arch. Biochem. Biophys.
324
, 26 (1995)
Abstract
Further Categories Containing This Product:
COX Inhibitors
ALX-270-197
Revised 15-Jan-08
