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ALX-260-165
Revised 22-Oct-07
Ac-RCGVPD-NH2
SYNONYMS
MMP-3 Inhibitor
Stromelysin-1 Inhibitor
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Inhibitors
Ordering Information
Product Numbers:
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ALX-260-165-M001
1 mg
45.00 USD
ALX-260-165-M005
5 mg
180.00 USD
Product Specification
SEQUENCE:
Ac-Arg-Cys-Gly-Val-Pro-Asp-NH
2
FORMULA:
C
27
H
46
N
10
O
9
S
MW:
686.8
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of matrix metalloproteinase 3 (MMP-3) (IC
50
=5µM).
Product Specific Literature References
Peptides based on the conserved predomain sequence of matrix metalloproteinases inhibit human stromelysin and collagenase:
A.C. Hanglow, et al.; Agents Actions
39
, C148 (1993)
Abstract
Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases:
N. Fotouhi, et al.; J. Biol. Chem.
269
, 30227 (1994)
Abstract
ALX-350-334
Revised 03-Apr-08
Ascochlorin
SYNONYMS
LL-Z 1272 γ
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
Ordering Information
Product Numbers:
Format:
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ALX-350-334-MC05
0.5 mg
320.00 USD
Product Specification
FORMULA:
C
23
H
29
ClO
4
MW:
404.9
CAS NUMBER:
26166-39-2
RTECS:
VH3707560
SOURCE/HOST:
Isolated from
Acremonium
sp. MST-FP1890.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to light grey powder.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antitumor antibiotic. Shows antiviral activity. Inhibitor or matrix metalloproteinase 9 (MMP-9). Reduces the inflammatory response to TNF-α in rat vascular smooth muscle cells. May be useful as an antiatherogenic agent.
Product Specific Literature References
Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I):
G. Tamura, et al.; J. Antibiot. (Tokyo)
21
, 539 (1968)
Abstract
Ascochlorin derivatives as ligands for nuclear hormone receptors:
M. Togashi, et al.; J. Med. Chem.
46
, 4113 (2003)
Abstract
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells:
S. Hong, et al.; J. Biol. Chem.
280
, 25202 (2005)
Abstract
;
Full Text
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines:
K. Sakaguchi, et al.; BBRC
329
, 46 (2005)
Abstract
Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages:
J.H. Kang, et al.; J. Cell. Biochem.
102
, 506 (2007)
Abstract
Further Categories Containing This Product:
MMP Inhibitors
•
Antibiotics for Cytoskeletal Research
•
Antibiotics for Inflammation Research
•
Antibiotics - Antiviral/Anti-HIV
ALX-260-120
Revised 12-Dec-07
Dnp-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Substrates
Ordering Information
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ALX-260-120-M005
5 mg
250.00 USD
Product Specification
SEQUENCE:
2,4-Dinitrophenyl-Pro-Leu-Gly-Met-Trp-Ser-Arg-OH
FORMULA:
C
44
H
61
N
13
O
13
S
MW:
1012.1
PURITY:
≥95% (HPLC)
APPEARANCE:
Yellow solid
SOLUBILITY:
Soluble in DMSO; dilute with distilled water or buffer.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Fluorogenic substrate for MMP-2 and MMP-9. Excitation: 280nm; emission 360nm.
Product Specific Literature References
Continuously recording fluorescent assays optimized for five human matrix metalloproteinases
:
S. Netzel-Arnett, et al.; Anal. Biochem.
195
, 86 (1991)
Abstract
ALX-380-273
Revised 03-Apr-08
Doxycycline . hyclate
SYNONYMS
Doxycycline . hydrochloride . hemiethanolate . hemihydrate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics for Angiogenesis Research
Ordering Information
Product Numbers:
Format:
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ALX-380-273-G001
1 g
20.00 USD
ALX-380-273-G005
5 g
60.00 USD
Product Specification
FORMULA:
C
22
H
24
N
2
O
8
. HCl . 0.5C
2
H
6
O . 0.5H
2
O
MW:
444.4 . 36.5 . 23.0 . 9.0
CAS NUMBER:
24390-14-5
MERCK INDEX:
14:
3440
RTECS:
QI8925000
SOURCE/HOST:
Semisynthetic from oxytetracycline.
PURITY:
≥98% (Assay on dry basis)
APPEARANCE:
Yellow crystalline solid.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
HAZARD:
HARMFUL. MAY BE TERATOGENIC. MAY BE CARCINOGENIC.
Product Description
Broad spectrum antibiotic and bacteriostatic. Shows antiprotozoal properties. Potent inhibitor of MMPs (matrix metalloproteinases)
in vivo
. Inhibits collagen synthesis.
Product Specific Literature References
Alpha-6-deoxyoxytetracycline. I. Some biological properties:
A.R. English; Proc. Soc. Exp. Biol. Med.
122
, 1107 (1966)
Abstract
A compilation of LD50 values in newborn and adult animals:
E.I. Goldenthal; Toxicol. Appl. Pharmacol.
18
, 185 (1971)
Abstract
An efficacy trial of doxycycline chemoprophylaxis against leptospirosis:
E.T. Takafuji, et al.; N. Engl. J. Med.
310
, 497 (1984)
Abstract
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential:
K. Suomalainen, et al.; Antimicrob. Agents Chemother.
36
, 227 (1992)
Abstract
Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline:
R. Hanemaaijer, et al.; J. Biol. Chem.
272
, 31504 (1997)
Abstract
;
Full Text
Doxycycline and tissue repair in rats:
S. Lamparter, et al.; J. Lab. Clin. Med.
139
, 295 (2002)
Abstract
Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry:
R.A. Garcia, et al.; Mol. Pharmacol.
67
, 1128 (2005)
Abstract
;
Full Text
Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices:
C. Franco, et al.; Am. J. Pathol.
168
, 1697 (2006)
Abstract
;
Full Text
Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia:
D. Burggraf, et al.; Neurobiol. Dis.
25
, 506 (2007)
Abstract
Further Categories Containing This Product:
Antitumor Agents (Anti-proliferative)
•
Antitumor Agents (Enzyme Inhibitors)
•
MMP Inhibitors
•
Antitumor Antibiotics
ALX-420-039
Revised 14-Aug-08
Imiquimod
SYNONYMS
1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine
R-837
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TLR Agonists Other Products
Ordering Information
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Format:
Size:
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ALX-420-039-M100
100 mg
55.00 USD
ALX-420-039-M250
250 mg
120.00 USD
Product Specification
FORMULA:
C
14
H
16
N
4
MW:
240.3
CAS NUMBER:
99011-02-6
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C.
Product Description
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Specific Literature References
Imiquimod applied topically: a novel immune response modifier and new class of drug:
R.L. Miller, et al.; Int. J. Immunopharmacol.
21
, 1 (1999)
Abstract
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway:
H. Hemmi, et al.; Nat. Immunol.
3
, 196 (2002)
Abstract
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases:
C. Hesling, et al.; Br. J. Dermatol.
150
, 761 (2004)
Abstract
Imiquimod as an antiangiogenic agent:
V.W. Li, et al.; J. Drugs Dermatol.
4
, 708 (2005)
Abstract
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis:
S. Majewski, et al.; Int. J. Dermatol.
44
, 14 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.
Related Products:
- ddWater (endotoxin-free) (Prod. No.
ALX-505-008
)
- PBS (endotoxin-free) (Prod. No.
ALX-505-007
)
Related Products
ALX-505-007
PBS (endotoxin-free)
ALX-505-008
ddWater (endotoxin-free)
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers)
•
Angiogenesis Modulators Other Products
•
MMPs Other Products
•
Inflammasome
ALX-350-145
Revised 28-Mar-07
Isobavachalcone
SYNONYMS
2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Antitumor Reagents
Ordering Information
Product Numbers:
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Size:
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ALX-350-145-M001
1 mg
190.00 USD
Product Specification
FORMULA:
C
20
H
20
O
4
MW:
324.4
CAS NUMBER:
20784-50-3
SOURCE/HOST:
Isolated from plant
Psoralea corylifolia
.
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow oil.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR,
13
C-NMR and MS.
Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia:
W.J. Tsai, et al.; J. Nat. Prod.
59
, 671 (1996)
Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae):
H. Haraguchi, et al.; Phytother. Res.
16
, 539 (2002)
Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects:
T. Akihisa, et al.; Cancer Lett.
201
, 133 (2003)
Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa:
N.O. Omisore, et al.; Braz. J. Med. Biol. Res.
38
, 1087 (2005)
Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects:
T. Akihisa, et al.; J. Nat. Prod.
69
, 38 (2006)
Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.:
B. Ngameni, et al.; Arkivoc
ix
, 91 (2007)
Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation/Transcription
•
Antitumor Agents (Anti-proliferative)
•
Antithrombotic Agents/Related Products
•
MMP Inhibitors
•
Flavonoids/Related Products
•
Natural Products - Antifungal Agents
•
Epstein Barr Virus/Related Products
ALX-270-280
Revised 07-Apr-08
clasto-Lactacystin β-lactone (synthetic)
SYNONYMS
Omuralide
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Proteasome/Ubiquitin Modulators
Ordering Information
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Format:
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ALX-270-280-C200
200 µg
280.00 USD
ALX-270-280-M001
1 mg
1'295.00 USD
Product Specification
FORMULA:
C
10
H
15
NO
4
MW:
213.2
CAS NUMBER:
155975-72-7
SOURCE/HOST:
Synthetic.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
20mg/ml soluble in DMSO or acetonitrile.
ACTIVITY:
K
obs
/[I]=20’000M
-1
s
-1
versus 20S:PA28 complex.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Subject to hydrolysis in aqueous buffers. We do not recommend storing the aqueous solutions for more than one day.
HANDLING:
Protect from light.
IDENTITY:
Determined by
1
H-NMR.
Product Description
Highly specific, cell permeable, and irreversible 20S proteasome inhibitor. Inhibits ubiquitin proteasome pathway in cell culture (IC
50
=1µM). It has been suggested that the natural product lactacystin acts as a precursor for
clasto
-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome. Inhibits cathepsin A. Leads to a reduction of adipogenesis.
Product Specific Literature References
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin:
G. Fenteany, et al.; Science
268
, 726 (1995)
Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone:
L.R. Dick, et al.; J. Biol. Chem.
271
, 7273 (1996)
Abstract
Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells:
L.R. Dick, et al.; J. Biol. Chem.
272
, 182 (1997)
Abstract
;
Full Text
Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation:
A. Craiu, et al.; J. Biol. Chem.
272
, 13437 (1997)
Abstract
;
Full Text
Lactacystin, proteasome function, and cell fate:
G. Fenteany & S.L. Schreiber; J. Biol. Chem.
273
, 8545 (1998)
Abstract
;
Full Text
Total synthesis and biological activity of lactacystin, omuralide and analogs:
E.J. Corey & W.D. Li; Chem. Pharm. Bull.
47
, 1 (1999)
Abstract
Lactacystin, a proteasome inhibitor: discovery and its application in cell biology:
H. Tomoda & S. Omura; Yakugaku Zasshi
120
, 935 (2000), Review
Abstract
Lactacystin inhibits cathepsin A activity in melanoma cell lines:
L. Kozlowski, et al.; Tumour Biol.
22
, 211 (2001)
Abstract
Inhibition of human preadipocyte proteasomal activity by HIV protease inhibitors or specific inhibitor lactacystin leads to a defect in adipogenesis, which involves matrix metalloproteinase-9:
S. De Barros, et al.; J. Pharmacol. Exp. Ther.
320
, 291 (2007)
Abstract
Effect of proteasome inhibitor clasto-lactacystin-beta-lactone on the proteome of the haloarchaeon Haloferax volcanii:
P.A. Kirkland, et al.; Microbiology
153
, 2271 (2007)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
•
Proteasome/Related Products
•
MMP Inhibitors
ALX-201-415
Revised 09-Jul-08
Lipocalin-2 (mouse) (recombinant)
SYNONYMS
NGAL (mouse) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (mouse) (recombinant)
Siderocalin (mouse) (recombinant)
Oncogene 24p3 (mouse) (recombinant)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adipokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-201-415-C010
10 µg
150.00 USD
ALX-201-415-C050
50 µg
320.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The mature peptide of mouse lipocalin-2 (aa 1-200) is fused to a FLAG
®
-tag at the C-terminus.
CONCENTRATION:
0.3mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P11672:
Lipocalin-2 (mouse)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Related Products
ALX-201-417
Lipocalin-2 (rat) (recombinant)
ALX-201-411
Lipocalin-2 (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
MMPs Other Products
•
Cholesterol & Lipid Transport/Related Products
ALX-201-417
Revised 05-Jun-08
Lipocalin-2 (rat) (recombinant)
SYNONYMS
NGAL (rat) (recombinant)
Neutrophil Gelatinase-associated Lipocalin (rat) (recombinant)
Siderocalin (rat) (recombinant)
Oncogene 24p3 (rat) (recombinant)
PRODUCT LINE
Obesity & Adipokines
PRODUCT CATEGORY
Adipokines Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-417-C010
10 µg
150.00 USD
ALX-201-417-C050
50 µg
320.00 USD
Product Specification
SOURCE/HOST:
Produced in HEK 293 cells. The mature peptide of rat lipocalin-2 (aa 1-198) is fused to a FLAG
®
-tag at the C-terminus.
CONCENTRATION:
0.3mg/ml
PURITY:
≥90% (SDS-PAGE)
FORMULATION:
Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT:
<1EU/µg protein (LAL-test).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P30152:
Lipocalin-2 (rat)
FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER
Manufactured by AdipoGen, Inc.
Related Products
ALX-201-415
Lipocalin-2 (mouse) (recombinant)
ALX-201-411
Lipocalin-2 (human) (recombinant)
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
•
MMPs Other Products
•
Cholesterol & Lipid Transport/Related Products
ALX-201-411
Revised 03-Apr-08
