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Natural Products / Antibiotics
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ALX-460-002 Revised 13-Mar-06
D-(+)-Biotin
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SYNONYMS Vitamin H
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-002-G001   1 g 30.00 USD Add To Cart
ALX-460-002-G005   5 g 140.00 USD Add To Cart
Product Specification
FORMULA: C10H16N2O3S
MW: 244.3
CAS NUMBER: 58-85-5
MERCK INDEX: 14: 1231
PURITY: ≥98%
SOLUBILITY: Soluble in hot water, diluted acids and alkaline solutions; hardly soluble in cold water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE CARCINOGENIC.

 
 
ALX-350-287 Revised 14-May-07
Bistheonellide A
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SYNONYMS Misakinolide A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-287-C100   100 µg 470.00 USD Add To Cart
Product Specification
FORMULA: C74H128O20
MW: 1337.8
CAS NUMBER: 105304-96-9
SOURCE/HOST: Isolated from the marine sponge Theonella sp.
PURITY: ≥95%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibits actin polymerization by forming a 1:2 complex with G-actin.
Product Specific Literature References
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell. Struct. Func. 21, 199 (1996) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. (Tokyo) 123, 571 (1998) Abstract
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Meth. Enzymol. 298, 26 (1998) Abstract
A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide: F. Braet, et al.; PNAS 95, 13635 (1998) Abstract
Effects of Bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells: T. Oda, et al.; Mar. Drugs 4, 22 (2006)
Further Categories Containing This Product:
Actin/Related Products
 
 
ALX-380-241 Revised 21-May-08
Blasticidin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-241-M001   1 mg 370.00 USD Add To Cart
Product Specification
FORMULA: C58H107NO23
MW: 1186.5 (free acid)
CAS NUMBER: 100513-53-9
RTECS: EC4897000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4079.
PURITY: ≥98% (HPLC)
APPEARANCE:

Yellow tan solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol; fairly soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Shows broad spectrum antifungal and antibacterial activity. Specific inhibitor of aflatoxin production by Aspergillus parasiticus.
Product Specific Literature References
Blasticidin, a new anti-phytopathogenic fungal substance: K. Fukunaga, et al.; Bull. Agr. Chem. Soc. Jpn. 19, 181 (1955)
Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus: S. Sakuda, et al.; J. Antibiot. 53, 1265 (2000) Abstract
Further Categories Containing This Product:
Natural Products - Antifungal Agents • Natural Products with Antibiotic Activity
 
 
ALX-380-089 Revised 29-Jul-08
Blasticidin S . hydrochloride
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - DNA Replication Inhibitors
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ALX-380-089-M100   100 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C17H26N8O5 . HCl
MW: 422.4 . 36.5
CAS NUMBER: 3513-03-9
MERCK INDEX: 14: 1316
SOURCE/HOST: Isolated from Streptomyces griseochromogenes.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water; insoluble in organic solvents.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Inhibitor of DNA and protein synthesis.
Product Specific Literature References
Blasticidin S, a new antibiotic: S. Takeuchi, et al.; J. Antibiot. (Tokyo) 11, 1 (1958) Abstract
The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome: M. Itaya, et al.; J. Biochem. 107, 799 (1990) Abstract
Cloning and characterization of the gene encoding a blasticidin S acetyltransferase from Streptoverticillum sp: J.A. Perez-Gonzalez, et al.; Gene 86, 129 (1990) Abstract
Blasticidin S-resistance gene (bsr): a novel selectable marker for mammalian cells: M. Izumi, et al.; Exp. Cell Res. 197, 229 (1991) Abstract
Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae: M. Kimura, et al.; Mol. Gen. Genet. 242, 121 (1994) Abstract
Blasticidin S deaminase gene from Aspergillus terreus (BSD): a new drug resistance gene for transfection of mammalian cells: M. Kimura, et al.; Biochim. Biophys. Acta 1219, 653 (1994) Abstract
Further Categories Containing This Product:
DNA Replication Inhibitors • Antibiotics - Antifungal • Reporter Gene Markers/Related Products • Translation Inhibitors
 
 
ALX-630-107 Revised 21-Feb-08
Bleomycin . sulfate
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SYNONYMS Blenoxane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-630-107-M010   10 mg 155.00 USD Add To Cart
ALX-630-107-M050   50 mg 595.00 USD Add To Cart
Product Specification
FORMULA: C55H82N17O21S3 . H2SO4
MW: 1413.6 . 98.1
CAS NUMBER: 9041-93-4
MERCK INDEX: 14: 1318
RTECS: EC5991990
SOURCE/HOST: A group of related glycopeptide antibiotics isolated from Streptomyces verticillus.
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (20mg/ml) or methanol.
ACTIVITY: 1'500-2'000 IU/mg
(corresponds to 1.5-2.0 bleomycin units (USP)/mg)
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Solutions in normal saline (~2mg/ml) are stable for 3 months when stored at +4°C in a glass container or stable for 1 month when stored at +4°C in a PVC container. Solutions in water are stable for several days only.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description

Radiomimetic DNA-cleaving agent that produces double and single DNA strand breaks through an oxygen-radical-dependent mechanism. Inhibits intracellular DNA replication. DNA alkylating agent. Antineoplastic.
Product Specific Literature References
Bleomycin and other antitumor antibiotics of high molecular weight: H. Umezawa; Antimicrobial Agents Chemother. (Bethesda) 5, 1079 (1965) Abstract
Specificity of deoxyribonucleic acid cleavage by bleomycin, phleomycin, and tallysomycin: J. Kross, et al.; Biochemistry 21, 4310 (1982) Abstract
Chromatin structure during bleomycin-induced DNA damage and repair
: B.P. Cuiffo, et al.; J. Free Radic. Biol. Med. 1, 139 (1985) Abstract
Cleavage of tRNA by Fe(II)-bleomycin: A. Huttenhofer, et al.; J. Biol. Chem. 267, 24471 (1992) Abstract
Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models: M. Schirner, et al.; Clin. Cancer Res. 4, 1331 (1998) Abstract
Sequence-specific changes in the metal site of ferric bleomycin induced by the binding of DNA: J.W. Sam, et al.; J. Biol. Chem. 273, 16090 (1998) Abstract
Changes in c-Jun but not Bcl-2 family proteins in p53-dependent apoptosis of mouse cerebellar granule neurons induced by DNA damaging agent bleomycin: T. Araki, et al.; Brain Res. 794, 239 (1998) Abstract
Induction of apoptosis by bleomycin in resting and cycling human lymphocytes: P. Vernole, et al.; Mutagenesis 13, 209 (1998) Abstract
Synergistic Effects of Laserthermia and Bleomycin-sulfate on Micronuclei Formation in Cytokinesis-blocked HeLa Cells: A.Sh. Monfared & H. Mozdarani; Irn. J. Med. Sci. 24, 87 (1999)
Bleomycin: new perspectives on the mechanism of action: S.M. Hecht; J. Nat. Prod. 63, 158 (2000), (Review) Abstract
Bleomycin-induced alterations in DNA replication: relationship to DNA damage: J. Dziegielewski, et al.; Biochemistry 40, 704 (2001) Abstract
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • DNA Fragmentation & Chromatin Condensation
 
 
ALX-380-102 Revised 03-Apr-08
Borrelidin
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SYNONYMS 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Treponemycin
U 78548
C2989
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cell Cycle Research
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ALX-380-102-MC05   0.5 mg 160.00 USD Add To Cart
ALX-380-102-M001   1 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C28H43NO6
MW: 489.7
CAS NUMBER: 7184-60-3
RTECS: ED8750000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Antibiotic. Inhibitor of bacterial and eukaryal threonyl-tRNA synthetase (ThrRS). Inhibitor of cyclin-dependent kinase (CDK). Shows angiogenesis inhibiting and antiviral activity.
Product Specific Literature References
Isolation of a cDNA clone for human threonyl-tRNA synthetase: amplification of the structural gene in borrelidin-resistant cell lines: K.J. Kontis and S.M. Arfin; Mol. Cell. Biol. 9, 1832 (1989) Abstract
Genetic analysis of mutations causing borrelidin resistance by overproduction of threonyl-transfer ribonucleic acid synthetase: J. Frohler, et al.; J. Bacteriol. 143, 1135 (1980) Abstract; Full Text
Increased levels of threonyl-tRNA synthetase in a borrelidin-resistant Chinese hamster ovary cell line: J.S. Gantt, et al.; PNAS 78, 5367 (1981) Abstract; Full Text
Chinese hamster ovary cells resistant to borrelidin overproduce threonyl-tRNA synthetase: S.C. Gerken and S.M. Arfin; J. Biol. Chem. 259, 9202 (1984) Abstract; Full Text
Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae: E. Tsuchiya, et al.; J. Antibiot. 54, 84 (2001) Abstract
Borrelidin induces the transcription of amino acid biosynthetic enzymes via a GCN4-dependent pathway: E.L. Eastwood and S.E. Schaus; Bioorg. Med. Chem. Lett. 13, 2235 (2003) Abstract
Isolation of vivomycin and borrelidin, two antibiotics with anti-viral activity, from a species of Streptomyces (C2989): M. Lumb, et al.; Nature 206, 263 (1965) Abstract
A unique hydrophobic cluster near the active site contributes to differences in borrelidin inhibition among threonyl-tRNA synthetases: B. Ruan, et al.; J. Biol. Chem. 280, 571 (2005) Abstract; Full Text
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • tRNA/Related Products • Antibiotics - Antiviral/Anti-HIV • Antibiotics for Angiogenesis Research
 
 
ALX-350-019 Revised 17-Apr-08
(+)-Brefeldin A
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SYNONYMS BFA
Ascotoxin
Decumbin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-350-019-M005   5 mg 80.00 USD Add To Cart
ALX-350-019-M010   10 mg 130.00 USD Add To Cart
ALX-350-019-M025   25 mg 270.00 USD Add To Cart
ALX-350-019-M050   50 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C16H24O4
MW: 280.4
CAS NUMBER: 20350-15-6
MERCK INDEX: 14: 1369
SOURCE/HOST: Isolated from Eupenicillium brefeldianum.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methylene chloride or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibitor of intracellular protein transport and protein secretion, interfering with trafficking in the trans-Golgi network, leading to the accumulation of cycling proteins in ERGIC clusters. Blocks ADP-ribosylation factor (Arf) in an inactive GDP-bound conformation and thereby prevents binding of COPI coats to ERGIC and Golgi membranes. Upon brefeldin A treatment the Golgi rapidly tubulates and fuses with the ER by an energy-, temperature-, and microtubule-dependent process. In contrast, the drug has little effect on the ERGIC, which keeps its identity, although the ERGIC clusters become larger and more uniformly distributed in the cytoplasm of the cells. Inhibits intracellular collagen degradation. Also inhibits apical Na+ channels in epithelia. Induces apoptosis.
Product Specific Literature References
Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958)
Über die Isolierung neuer Stoffwechselprodukte aus Penicillium brefeldianum Dodge.: E. Harri, et al.; Helv. Chim. Acta 46, 1235 (1963)
Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) Abstract; Full Text
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) Abstract; Full Text
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis: B.D. Price, et al.; J. Cell. Physiol. 152, 545 (1992) Abstract
Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992), (Review) Abstract
Brefeldin A inhibits degradation as well as production and secretion of collagen in human lung fibroblasts: C.R. Ripley, et al.; J. Biol. Chem. 268, 3677 (1993) Abstract
Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) Abstract
Brefeldin A inhibition of apical Na+ channels in epithelia: R.S. Fisher, et al.; Am. J. Physiol. 270, C138 (1996) Abstract
Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002), Review Abstract
NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8+ T cells in vivo: D. Stober, et al.; J. Immunol. 170, 2540 (2003) Abstract; Full Text
Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70: K.F. Xu, et al.; PNAS 102, 2784 (2005) Abstract
Further Categories Containing This Product:
Golgi Apparatus • ADP Ribosylation Factor [ARF]/Related Products • Collagen/Related Products • Na+ Channels • Autophagy Other Products • Antibiotics - Antifungal • Antitumor Antibiotics • Antitumor Agents (Apoptosis Inducers) • Antibiotics - Antiviral/Anti-HIV
 
 
ALX-450-003 Revised 03-Apr-08
4-Bromo-A23187
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SYNONYMS 4-Bromo-Calcimycin
4-Bromo-Calcium Ionophore A23187
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
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ALX-450-003-M001   1 mg 85.00 USD Add To Cart
ALX-450-003-M005   5 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H36BrN3O6
MW: 602.5
CAS NUMBER: 76455-82-8
SOURCE/HOST: Semisynthetic.
PURITY: ≥85%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in methanol or methylene chloride.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: TOXIC.

Product Description
Brominated analog of the widely used calcium ionophore A23187 (Prod. No. ALX-450-001). Nonfluorescent, and therefore used as a calibration standard for determining cytoplasmic calcium ions by fluorescent probes.
Product Specific Literature References
Bromo-A23187: a nonfluorescent calcium ionophore for use with fluorescent probes: C.M. Deber, et al.; Anal. Biochem. 146, 349 (1985) Abstract
Calcium transport by ionophorous peptides in dog and human lymphocytes detected by quin-2 fluorescence: C.M. Deber & L.C. Hsu; BBRC 134, 731 (1986) Abstract
Ionophore bromo-A23187 reveals cellular calcium stores in single pituitary somatotropes
: R.W. Holl, et al.; Mol. Cell. Endocrinol. 64, 105 (1989) Abstract
The mitochondrial permeability transition mediates both necrotic and apoptotic death of hepatocytes exposed to Br-A23187
: T. Qian, et al.; Toxicol. Appl. Pharmacol. 154, 117 (1999) Abstract
 
 
ALX-385-029 Revised 08-Apr-08
4’-Bromoflavone
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SYNONYMS 4’-Bromo-2-phenylbenzopyran
4’-Bromo-2-phenyl-4H-1-benzopyran-4-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-029-G001   1 g 90.00 USD Add To Cart
Product Specification
FORMULA: C15H9BrO2
MW: 301.1
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Chemopreventive compound. Potent inducer of phase II detoxifying enzymes. Quininone reductase and glutathione S-transferase in cell culture and different tissues of rats. Aryl hydrocarbon hydroxylase inducer.
Product Specific Literature References
Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues: K. Burki, et al.; Biochem. Genet. 13, 417 (1975) Abstract
Cancer chemopreventive activity mediated by 4’-bromoflavone, a potent inducer of phase II detoxification enzymes: L.L. Song, et al.; Cancer Res. 59, 578 (1999) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products • Natural Products - Chemopreventive Agents
 
 
ALX-350-005