• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Antitumor Reagents
You are here: Product Lines > Cancer > Antitumor Reagents
 
Toolbar - View Selection
 
 Items 1-20 of 310 Page 1 of 16 Select Page: 1 2 3 4 5 6 7 8 9 10  >>  
ALX-350-124 Revised 05-Apr-08
Ferulenol
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-124-M001   1 mg 45.00 USD Add To Cart
ALX-350-124-M005   5 mg 135.00 USD Add To Cart
ALX-350-124-M010   10 mg 230.00 USD Add To Cart
Product Specification
FORMULA: C24H30O3
MW: 366.5
CAS NUMBER: 6805-34-1
SOURCE/HOST: Isolated from Ferula communis.
PURITY: ≥96%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol and methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Prenylated 4-hydroxycoumarin. Antitubercular antibiotic with potent activity against Mycobacteria. Exerts taxol-like and dose-dependent cytotoxicity against various human tumor cell lines. Stimulator of tubulin polymerisation in vitro and inhibitor of colchicine binding to tubulin. Antithrombotic, depressing the activity of all vitamin K-dependent coagulation factors. Shows lower acute toxicity and higher activity than warfarin. Shows hepatocyte toxicity.
Product Specific Literature References
Experimental studies on the toxicity of some compounds isolated from Ferula communis in the rat: S. Tagliapietra, et al.; Res. Commun. Chem. Pathol. Pharmacol. 66, 333 (1989) Abstract
Plasma ferulenol concentration and activity of clotting factors in sheep with Ferula communis variety brevifolia intoxication: N. Tligui, et al.; Am. J. Vet. Res. 55, 1564 (1994) Abstract
Antibacterial constituents from the rhizomes of Ferula communis: M.A. Al-Yahya, et al.; Phytother. Res. 12, 335 (1998)
Microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol: C. Bocca, et al.; Planta Med. 68, 1135 (2002) Abstract
Acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from Ferula communis L: O. Fraigui, et al.; Vet. Hum. Toxicol. 44, 5 (2002) Abstract
Characterization of anti-coagulant properties of prenylated coumarin ferulenol: M. Monti, et al.; Biochim. Biophys. Acta 1770, 1437 (2007) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Natural Products for Cell Cycle Research • Natural Products - Antitumor Reagents
 
 
ALX-351-001 Revised 08-Apr-08
Paclitaxel
Add to Clipboard
SYNONYMS Taxol®
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-351-001-M001   1 mg 20.00 USD Add To Cart
ALX-351-001-M005   5 mg 50.00 USD Add To Cart
ALX-351-001-M025   25 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C47H51NO14
MW: 853.9
CAS NUMBER: 33069-62-4
MERCK INDEX: 14: 6982
RTECS: DA8340700
SOURCE/HOST: Isolated from Taxus brevifolia.
PURITY: ≥98%
APPEARANCE: Off-white crystalline powder.
SOLUBILITY: Soluble in acetonitrile, DMSO or methanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
HAZARD: MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.
IDENTITY: Determined by IR.

Product Description

Antitumor agent. Binds to tubulin. Promotes assembly and inhibits disassembly of microtubules. Blocks the cell cycle at the mitotic phase and induces apoptosis. The checkpoint of mitotic spindle assembly, aberrant activation of cyclin-dependent kinases (CDKs) and the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) are involved in paclitaxel-induced apoptosis.
Product Specific Literature References
CDK4 down-regulation induced by paclitaxel is associated with G1 arrest in gastric cancer cells: Y.D. Yoo, et al.; Clin Cancer Res 4, 3063 (1998) Abstract
Molecular effects of paclitaxel: myths and reality (a critical review): M.V. Blagosklonny & T. Fojo; Int. J. Cancer 83, 151 (1999) Abstract
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together: T.H. Wang, et al.; Cancer 88, 2619 (2000) Abstract
Disruption of Cell Adhesion and Caspase-Mediated Proteolysis of beta- and gamma-Catenins and APC Protein in Paclitaxel-Induced Apoptosis:: Y.H. Ling, et al.; Mol. Pharmaco. 59, 593 (2001) Abstract; Full Text
Taxol: biosynthesis, molecular genetics, and biotechnological applications: S. Jennewein and R. Croteau; Appl. Microbiol. Biotechnol. 57, 13 (2001) Abstract
Chemistry and chemical biology of taxane anticancer agents: M.L. Miller and I. Ojima; Chem. Rec. 1, 195 (2001) Abstract
Paclitaxel and its formulations: A.K. Singla, et al.; Int. J. Pharm. 235, 179 (2002) Abstract
Paclitaxel in cancer therapy: T.M. Mekhail and M. Markman; Expert. Opin. Pharmacother. 3, 755 (2002) Abstract
Taxol reactions: K.S. Price and M.C. Castells; Allergy Asthma Proc. 23, 205 (2002) Abstract
The chemistry of taxol and related taxoids: D.G. Kingston, et al.; Fortschr. Chem. Org. Naturst. 84, 53 (2002) Abstract
Overcoming multidrug resistance in taxane chemotherapy: R. Geney, et al.; Clin. Chem. Lab. Med. 40, 918 (2002) Abstract
Taxanes: microtubule and centrosome targets, and cell cycle dependent mechanisms of action: M. Abal, et al.; Curr. Cancer Drug Targets 300, 193 (2003) Abstract
Paclitaxel: as adjuvant or neoadjuvant therapy in early breast cancer: D. Simpson & G.L. Plosker; Drugs 64, 1839 (2004), Review Abstract
Paclitaxel for AIDS-associated Kaposi’s sarcoma: T. Dhillon, et al.; Expert Rev. Anticancer Ther. 5, 215 (2005), Review Abstract
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo: P. Wagner, et al.; Cell Cycle 4, 1149 (2005), Review Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators • Alkaloids • TLR Agonists Other Products
 
 
ALX-351-005 Revised 07-Jan-08
Baccatin III
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-351-005-M005   5 mg 85.00 USD Add To Cart
ALX-351-005-M025   25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C31H38O11
MW: 586.6
CAS NUMBER: 27548-93-2
SOURCE/HOST: Semisynthetic.
PURITY: ≥95%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO or 100 % ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description
Starting material for the synthesis of taxol analogs. Shows antitumor properties.
Product Specific Literature References
Recent advances in the chemistry of taxol: D.G. Kingston; J. Nat. Prod. 63, 726 (2000) Abstract
Further Categories Containing This Product:
Taxol / Related Products
 
 
ALX-351-006 Revised 07-Jan-08
Baccatin III, 10-Deacetyl-
Add to Clipboard
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-351-006-M005   5 mg 190.00 USD Add To Cart
ALX-351-006-M025   25 mg 590.00 USD Add To Cart
Product Specification
FORMULA: C29H36O10
MW: 544.6
CAS NUMBER: 32981-86-5
SOURCE/HOST: Isolated from Taxus baccata.
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description
Intermediate for the preparation of taxol analogs.
Product Specific Literature References
Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators
 
 
ALX-270-361 Revised 28-Sep-07
Indirubin
Add to Clipboard
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-361-M001   1 mg 50.00 USD Add To Cart
ALX-270-361-M005   5 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C16H10N2O2
MW: 262.3
CAS NUMBER: 479-41-4
SOURCE/HOST: Synthetic.
PURITY: ≥98% (1H-NMR, HPLC)
APPEARANCE: Purple powder.
SOLUBILITY: Soluble in DMSO (10mg/ml) or methanol (0.3mg/ml). Sparingly soluble in aqueous buffers (12.5µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 2 years when stored at +4°C in the dark. Stock solutions should be stored in the dark and used within 1 month.
HANDLING: Keep cool and dry. Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR, IR, ESI-MS and UV.

Product Description
Inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50=10µM), CDK2/cyclin A (IC50=2.2µM), CDK2/cyclin E (IC50=7.5µM), CDK4/cyclin D1 (IC50=12µM), CDK5/p35 (IC50=5.5µM)) [1] and of GSK-3β (IC50=600nM) [2]. Inhibits inflammatory reaction in delayed-type hypersensitivity in mice [3]. Ligand of human aryl hydrocarbon receptor [4]. Exhibits anti-cancer activity [5] [6].
Product Specific Literature References
[1] Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nature Cell Biol. 1, 60 (1999) Abstract
[2] Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001) Abstract; Full Text
[3] Indirubin inhibits inflammatory reactions in delayed-type hypersensitivity: T. Kunikata, et al.; Eur. J. Pharmacol. 410, 93 (2000) Abstract
[4] Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine: J. Adachi, et al.; J. Biol. Chem. 276, 31475 (2001) Abstract; Full Text
[5] Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine: G. Eisenbrand, et al.; J. Cancer Res. Clin. Oncol. 130, 627 (2004) Abstract
[6] Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway: G. Sethi, et al.; J. Biol. Chem. 281, 23425 (2006) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Indirubin is derived from various natural sources, such as Indigofera indica, Isatis tinctoria and I. indigotica by fermentation, oxidation and the presence of light as a by product of indigo formation. Indirubin is also present in human urine and fetal bovine serum [4]. Preclinical studies of indirubin its confirmed anti-tumor activity. Efficacy against chronic myelocytic leukemia was demonstrated in clinical trials in China [2].
Related Products
Further Categories Containing This Product:
Anti-inflammatory Agents Other Products • GSK-3 Inhibitors • Antitumor Reagents Other Products
 
 
ALX-300-001 Revised 02-Dec-04
1-O-Hexadecyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)-ethanolamide . sodium salt
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-001-M005   5 mg 85.00 USD Add To Cart
ALX-300-001-M025   25 mg 335.00 USD Add To Cart
Product Specification
FORMULA: C53H105NO8P . Na
MW: 915.4 . 23.0
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent antitumor agent.
Product Specific Literature References
Biologically active ether lipids. Biotransformation of rac-1(3)-O- alkylglycerols in cell suspension cultures of rape and semisynthesis of 1-O-alkyl-2-palmitoyl-sn-glycero-3-phospho-(N-palmitoyl)ethanolamines, potent antitumor agents: S.S. Apte, et al.; FEBS Lett. 265, 104 (1990) Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-300-092 Revised 09-Dec-04
Tetradecyl-phosphocholine
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-092-M250   250 mg 50.00 USD Add To Cart
ALX-300-092-G001   1 g 150.00 USD Add To Cart
Product Specification
FORMULA: C19H42NO4P
MW: 379.5
PURITY: ≥99%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potential antitumor agent.
Product Specific Literature References
H.R. Berger, et al.; Akt. Onkologie 34, 27 (1987)
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-300-094 Revised 18-Jul-07
Octadecyl-phosphocholine
Add to Clipboard
SYNONYMS C18:0-PC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-094-M250   250 mg 45.00 USD Add To Cart
ALX-300-094-G001   1 g 135.00 USD Add To Cart
Product Specification
FORMULA: C23H50NO4P
MW: 435.6
PURITY: ≥99% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Potential antitumor agent.
Product Specific Literature References
H.R. Berger, et al.; Akt. Onkologie 34, 27 (1987)
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-300-152 Revised 09-Feb-05
1-Elaidylphosphocholine (C18:1, trans)
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phospholipids / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-152-M250   250 mg 80.00 USD Add To Cart
ALX-300-152-G001   1 g 240.00 USD Add To Cart
Product Specification
FORMULA: C23H48NO4P
MW: 433.6
PURITY: ≥98%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.
Product Description
Cytotoxic alkylphosphocholine for a variey of tumor cells and protozoal diseases (leishmaniasis).
General Literature References
Hexadecylphosphocholine: a new and selective antitumor drug: H. Eibl & C. Unger; Cancer Treat. Rev. 17, 233 (1990), (Review) Abstract
Induction of tumor cell differentiation by alkylphosphocholines: a new approach for in vitro screening: H.R. Maurer & P. Hilgard; Prog. Exp. Tumor Res. 34, 90 (1992), (Review) Abstract
Alkylphosphocholines: a new class of membrane-active anticancer agents: P. Hilgard, et al.; Cancer Chemother. Pharmacol. 32, 90 (1993), (Review) Abstract
Current concepts of treatment in medical oncology: new anticancer drugs: C. Unger; J. Cancer Res. Clin. Oncol. 122, 189 (1996), (Review) Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-400-040 Revised 13-Aug-07
Cisplatin
Add to Clipboard
SYNONYMS cis-Platinum(ll)diamine dichloride
PRODUCT LINE Cancer