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Antibiotics - Antifungal
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ALX-380-130 Revised 15-Sep-08 New product
Isofusidienol A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-130-M001   1 mg 90.00 USD Add To Cart
ALX-380-130-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C16H12O6
MW: 300.3
SOURCE/HOST: Isolated from Chalara sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Chromone-3-oxepine. Displays antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Specific Literature References
Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp: S. Lösgen, et al.; Eur. J. Org. Chem. 2008, 698
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-230 Revised 07-Apr-08
Kazusamycin A
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SYNONYMS Kazusamycin
Hydroxyleptomycin B
Antibiotic CL 1957B
Hydroxyelactocin
PD 114,721
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-230-MC01   0.1 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C33H48O7
MW: 556.7
CAS NUMBER: 92090-94-3
RTECS: OA0550000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4898.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless film.
SOLUBILITY: Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows potent antitumor activity in vitro and in vivo against several tumor cell lines. Has antibacterial and antifungal activities. Inhibitor of nuclear export.
Product Specific Literature References
A new antitumor antibiotic, kazusamycin: I. Umezawa, et al.; J. Antibiot. (Tokyo) 37, 706 (1984) Abstract
Antitumor activity of a new antibiotic, kazusamycin: K. Komiyama, et al.; J. Antibiot. (Tokyo) 38, 224 (1985) Abstract
Novel antitumor antibiotics, CI-940 (PD 114,720) and PD 114,721. Taxonomy, fermentation and biological activity: J.B. Tunac, et al.; J. Antibiot. (Tokyo) 38, 460 (1985) Abstract
In vivo and in vitro anticancer activity of the structurally novel and highly potent antibiotic CI-940 and its hydroxy analog (PD 114,721): B.J. Roberts, et al.; Cancer Chemother. Pharmacol. 16, 95 (1986) Abstract
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997) Abstract; Full Text
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Antibiotics - Antifungal
 
 
ALX-380-231 Revised 14-Mar-08
Kazusamycin B
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SYNONYMS Hydroxyleptomycin A
Antibiotic CL 1957E
PD 124,895
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-231-MC01   0.1 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C32H46O7
MW: 542.7
CAS NUMBER: 107140-30-7
RTECS: OA0551000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4898.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless film.
SOLUBILITY: Soluble in 100% ethanol (recommended) or methanol. Unstable in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows potent antitumor activity in vitro and in vivo against several tumor cell lines, including L1210 and P388 leukemia cells. Has antibacterial and antifungal activities. Inhibitor of nuclear export.
Product Specific Literature References
PD 124,895 and PD 124,966, two new antitumor antibiotics: T.R. Hurley, et al.; J. Antibiot. (Tokyo) 39, 1651 (1986) Abstract
Kazusamycin B, a novel antitumor antibiotic: K. Funaishi, et al.; J. Antibiot. (Tokyo) 40, 778 (1987) Abstract
Antitumor effect of kazusamycin B on experimental tumors: E. Yoshida, et al.; J. Antibiot. (Tokyo) 40, 1596 (1987) Abstract
The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells: K. Takamiya, et al.; J. Antibiot. (Tokyo) 41, 1854 (1988) Abstract
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA: B. Wolff, et al.; Chem. Biol. 4, 139 (1997) Abstract; Full Text
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Antibiotics - Antifungal
 
 
ALX-380-101 Revised 12-Oct-07
Leptomycin A
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SYNONYMS ATS1287 A
LMA
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-101-C050   50 µg 75.00 USD Add To Cart
ALX-380-101-C100   100 µg 120.00 USD Add To Cart
Product Specification
FORMULA: C32H46O6
MW: 526.7
CAS NUMBER: 87081-36-5
SOURCE/HOST: Isolated from Streptomyces sp.
CONCENTRATION: 0.1mg/ml
PURITY: ≥95% (HPLC)
APPEARANCE: Liquid. In 100% ethanol.
SOLUBILITY: Soluble in methanol or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: FLAMMABLE. TOXIC.

Product Description
Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA.
Product Specific Literature References
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J Antibiot (Tokyo) 36, 639 (1983) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".
Further Categories Containing This Product:
Antibiotics for Cell Cycle Research • Nuclear Envelope & Nuclear Transport
 
 
ALX-380-100 Revised 14-Mar-08
Leptomycin B
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SYNONYMS LMB
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-100-C100   100 µg 95.00 USD Add To Cart
Product Specification
FORMULA: C33H48O6
MW: 540.7
CAS NUMBER: 87081-35-4
SOURCE/HOST: Isolated from Streptomyces sp.
CONCENTRATION: 0.2mg/ml
PURITY: ≥98% (HPLC)
FORMULATION: Liquid. In 100% ethanol.
SOLUBILITY: Soluble in methanol or 100% ethanol; insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Packaged under inert gas.
HAZARD: TOXIC. FLAMMABLE.

Product Description
Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA.
Product Specific Literature References
Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J. Antibiot. (Tokyo) 36, 639 (1983) Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms: T. Meissner, et al.; FEBS Lett. 576, 27 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Antibiotics for Cell Cycle Research • Nuclear Envelope & Nuclear Transport
 
 
ALX-850-313 Revised 14-Feb-07
Leptomycin Set I
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-850-313-KI01   1 Set 170.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 1x100µg of Leptomycin A (Prod. No. ALX-380-101)
1x100µg of Leptomycin B (Prod. No. ALX-380-100)
PURITY: ≥95% (HPLC)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
General Information
BACKGROUND/TECHNICAL INFORMATION Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Antibiotics for Cell Cycle Research • Nuclear Envelope & Nuclear Transport
 
 
ALX-850-316 Revised 01-Nov-07
Leptomycin Set II
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-850-316-KI01   1 Set 290.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 1x100µg of Leptomycin A (Prod. No. ALX-380-101)
1x100µg of Leptomycin B (Prod. No. ALX-380-100)
1x5µg of Ratjadone C (native) (Prod. No. ALX-270-369)
PURITY: ≥95% (HPLC)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
General Information
BACKGROUND/TECHNICAL INFORMATION Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".
Further Categories Containing This Product:
CDK & Cyclin Inhibitors • Antibiotics for Cell Cycle Research • Nuclear Envelope & Nuclear Transport
 
 
ALX-380-128 Revised 30-Jun-08
MM 47755
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SYNONYMS 6-Desoxy-8-O-methylrabelomycin
(-)-3,4-Dihydro-3-hydroxy-8-methoxy-3-methylbenz(a)anthracene-1,7,12(2H)-trione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-128-M001   1 mg 90.00 USD Add To Cart
ALX-380-128-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 117620-87-8
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Angucyclinone. Displays antibacterial and antifungal activity.
Product Specific Literature References
6-Deoxy-8-O-methylrabelomycin and 8-O-methylrabelomycin from a Streptomyces species: Y. Shigihara, et al.; J. Antibiot. 41, 1260 (1988) Abstract
MM 47755, a new benz[a]anthracene antibiotic from a streptomycete: M.L. Gilpin, et al.; J. Antibiot. 42, 627 (1989) Abstract
Remote Stereochemical Control in Asymmetric Diels - Alder Reactions: Synthesis of the Angucycline Antibiotics, (-)-Tetrangomycin and MM 47755: J.S. Landells, et al.; THL 44, 5193 (2003)
Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755): C. Kesenheimer & U. Groth; Org. Lett. 8, 2507 (2006) Abstract
Angucyclinone antibiotics: total syntheses of YM-181741, (+)-ochromycinone, (+)-rubiginone B2, (-)-tetrangomycin, and MM-47755: K.P. Kaliappan & V. Ravikumar; J. Org. Chem. 72, 6116 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-129 Revised 30-Jun-08
Naphthomycin B
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SYNONYMS 2-Demethylnaphthomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-129-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C39H44ClNO9
MW: 706.2
CAS NUMBER: 86825-88-9
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Ansamycin. Displays antibacterial and antifungal activity.
Product Specific Literature References
Isolation and structural elucidation of naphthomycins B and C: W. Keller-Schierlein, et al.; J. Antibiot. 36, 484 (1983) Abstract
Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces: H.J. Schiewe & A. Zeeck; J. Antibiot. 52, 635 (1999) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-037 Revised 20-Jun-08
Oligomycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-037-M005   5 mg 50.00 USD Add To Cart
ALX-380-037-M010   10 mg 95.00 USD Add To Cart
Product Specification
MW: 789.3
CAS NUMBER: 1404-19-9
MERCK INDEX: 14: 6833
RTECS: RK3325000
SOURCE/HOST: Isolated from Streptomyces diastatochromogens.
PURITY: ≥90% (mixture of oligomycin A, B, and C (~65% oligomycin A))
APPEARANCE: White to faint yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. MAY BE MUTAGENIC.

Product Description
Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993) Abstract
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993) Abstract
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993) Abstract
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994) Abstract
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998) Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000) Abstract
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000) Abstract
Further Categories Containing This Product:
Antibiotics - ATPase Inhibitors • Respiratory Chain Other Products • H+-ATPase / Related Products • Antitumor Antibiotics • Antibiotics - Antifungal
 
 
ALX-380-036 Revised 10-Dec-07
Oligomycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors