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ALX-270-035
Revised 07-Dec-04
Tyrphostin AG 1295
SYNONYMS
6,7-Dimethyl-2-phenylquinoxaline
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
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ALX-270-035-M001
1 mg
30.00 USD
ALX-270-035-M005
5 mg
80.00 USD
Product Specification
FORMULA:
C
16
H
14
N
2
MW:
234.3
CAS NUMBER:
71897-07-9
PURITY:
≥98%
APPEARANCE:
Tan solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
ALX-270-066
Revised 07-Apr-08
Lavendustin C
SYNONYMS
Compound 5
5-(N-2,5-Dihydroxybenzyl)aminosalicylic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Protein Kinase Inhibitors
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ALX-270-066-M001
1 mg
35.00 USD
Product Specification
FORMULA:
C
14
H
13
NO
5
MW:
275.3
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent inhibitor of protein tyrosine kinases and Ca
2+
/calmodulin-dependent kinase II. Acts also as an inhibitor of EGFR tyrosine kinase and pp60
c-
src
kinase.
Product Specific Literature References
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus:
T. Onoda, et al.; J. Nat. Prod.
52
, 1252 (1989)
Abstract
Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors:
T.J. O'Dell, et al.; Nature
353
, 558 (1991)
Abstract
Hypericin and pseudohypericin specifically inhibit protein kinase C: possible relation to their antiretroviral activity:
I. Takahashi, et al.; BBRC
165
, 1207 (1989)
Abstract
Inhibition of crystal-induced neutrophil activation by a protein tyrosine kinase inhibitor:
H.M. Burt, et al.; J. Leukoc. Biol.
55
, 112 (1994)
Abstract
Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway:
D. Lidington, et al.; J. Cell Physiol.
185
, 117 (2000)
Abstract
Related Products
ALX-350-084
Lavendustin C methyl ester
Further Categories Containing This Product:
CAM Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Lipopolysaccharides [LPS] / Related Products
ALX-270-088
Revised 07-Apr-05
ML-7 . hydrochloride
SYNONYMS
1-(5-Iodonaphthalene-1-sulfonyl)-1
H
-hexahydro-1,4-diazepine . HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrosine Kinase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
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ALX-270-088-M005
5 mg
40.00 USD
ALX-270-088-M025
25 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
17
IN
2
O
2
S . HCl
MW:
416.0 . 36.5
CAS NUMBER:
110448-33-4
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (can be further diluted with water), 100% ethanol (warm) or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits smooth-muscle myosin light chain kinase, protein kinase C (PKC), and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase:
M. Saitoh, et al.; J. Biol. Chem.
262
, 7796 (1987)
Abstract
;
Full Text
Further Categories Containing This Product:
PKC Inhibitors
•
PKA Inhibitors
•
Myosin Light Chain Kinase Inhibitors
ALX-270-098
Revised 16-Nov-06
Erbstatin analog
SYNONYMS
Methyl 2,5-dihydroxycinnamate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
EGFR Kinase Inhibitors
Ordering Information
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ALX-270-098-M005
5 mg
55.00 USD
Product Specification
FORMULA:
C
10
H
10
O
4
MW:
194.2
CAS NUMBER:
63177-57-1
PURITY:
≥98% (HPLC)
APPEARANCE:
Off-white to light brown crystalline solid.
SOLUBILITY:
Soluble in methanol, DMSO or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase. Considerably longer half-life in aqueous solution than erbstatin itself. Induces apoptosis.
Product Specific Literature References
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors:
K. Umezawa, et al.; FEBS Lett.
260
, 198 (1990)
Abstract
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells:
K. Umezawa, et al.; FEBS Lett.
314
, 289 (1992)
Abstract
Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins:
Y. Azuma, et al.; Cell Immunol.
152
, 271 (1993)
Abstract
Inhibition of Abelson oncogene function by erbstatin analogues:
M. Kawada, et al.; Drugs Exp. Clin. Res.
19
, 235 (1993)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
Apoptosis Inducers & Inhibitors Other Products
ALX-270-129
Revised 18-Jan-08
Tyrphostin AG 18
SYNONYMS
Tyrphostin A23
Tyrphostin RG 50858
Tyrphostin RG 50810
(3,4-Dihydroxybenzylidene)malononitrile
α-Cyano-(3,4-dihydroxy)cinnamonitrile
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
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ALX-270-129-M005
5 mg
35.00 USD
ALX-270-129-M025
25 mg
100.00 USD
Product Specification
FORMULA:
C
10
H
6
N
2
O
2
MW:
186.2
CAS NUMBER:
118409-57-7
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors:
A. Gazit, et al.; J. Med. Chem.
32
, 2344 (1989)
Abstract
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation:
R.M. Lyall, et al.; J. Biol. Chem.
264
, 14503 (1989)
Abstract
;
Full Text
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini:
R.D. Duan & J.A. Williams; Am. J. Physiol.
267
, G401 (1994)
Abstract
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex:
S. Kapas, et al.; Biochem. J.
305
, 433 (1995)
Abstract
Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein- tyrosine kinase:
R. Seger, et al.; J. Biol. Chem.
270
, 28325 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-141
Revised 07-Dec-04
Tyrphostin AG 527
SYNONYMS
Tyrphostin B44
(-)-(R)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
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Quantity:
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ALX-270-141-M005
5 mg
25.00 USD
ALX-270-141-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-32-0
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-142
Revised 11-Dec-04
Tyrphostin AG 555
SYNONYMS
Tyrphostin B46
N-(3-Phenylpropyl)-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
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ALX-270-142-M005
5 mg
25.00 USD
ALX-270-142-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
18
N
2
O
3
MW:
322.4
PURITY:
≥98%
SOLUBILITY:
Soluble in DMSO or ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-143
Revised 20-Feb-08
Tyrphostin AG 494
SYNONYMS
Tyrphostin B48
N-Phenyl-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-phenylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
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ALX-270-143-M005
5 mg
25.00 USD
ALX-270-143-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
16
H
12
N
2
O
3
MW:
280.3
CAS NUMBER:
133550-35-3
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Tyrphostin AG 494 blocks Cdk2 activation:
N. Osherov & A. Levitzki; FEBS Lett.
410
, 187 (1997)
Abstract
Inhibition of Cdk2 activation by selected tyrphostins causes cell cycle arrest at late G1 and S phase:
N. Kleinberger-Doron, et al.; Exp. Cell Res.
241
, 340 (1998)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
•
CDK & Cyclin Inhibitors
•
Cell Cycle Blockers & Inhibitors / Related Products
ALX-270-144
Revised 07-Dec-04
Tyrphostin AG 835
SYNONYMS
Tyrphostin B50
(+)-(S)-N-(α-Methylbenzyl)-3,4-dihydroxybenzylidenecyanoacetamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
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ALX-270-144-M005
5 mg
25.00 USD
ALX-270-144-M025
25 mg
90.00 USD
Product Specification
FORMULA:
C
18
H
16
N
2
O
3
MW:
308.3
CAS NUMBER:
133550-37-5
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-146
Revised 11-Dec-04
Tyrphostin AG 556
SYNONYMS
Tyrphostin B56
N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-N-(4-phenylbutyl)cinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-146-M005
5 mg
25.00 USD
ALX-270-146-M025
25 mg
85.00 USD
Product Specification
FORMULA:
C
20
H
20
N
2
O
3
MW:
336.4
CAS NUMBER:
133550-41-1
PURITY:
≥98%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Store tightly sealed in the dark. Protect from light.
Product Specific Literature References
Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases:
A. Gazit, et al.; J. Med. Chem.
34
, 1896 (1991)
Abstract
Further Categories Containing This Product:
EGFR Kinase Inhibitors
•
Tyrosine Kinase Inhibitors
ALX-270-168
Revised 18-May-06
Tyrphostin AG 490
SYNONYMS
Tyrphostin B42
N-Benzyl-3,4-dihydroxy-benzylidenecyanoacetamide
α-Cyano-(3,4-dihydroxy)-]N-benzylcinnamamide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Tyrphostins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-168-M005
5 mg
45.00 USD
ALX-270-168-M025
25 mg
190.00 USD
Product Specification
FORMULA:
C
17
H
14
N
2
O
3
MW:
294.3
CAS NUMBER:
133550-30-8
PURITY:
≥98%
APPEARANCE:
