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Obesity & Adipokines
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ALX-157-020 Revised 03-Mar-05
Galanin Like Peptide [GALP] (1-60) (pig)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Galanin & Galanin Receptor / Related Products
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ALX-157-020-MC01   0.1 mg 490.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA: C281H443N81O78
MW: 6204.1
CAS NUMBER: 245114-96-9
SOURCE/HOST: Isolated from pig hypothalamus.
PURITY: ≥95%
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC50=0.24nM) and a lower affinity for the galanin receptor 1 (IC50=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.
Product Specific Literature References
Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus: T. Ohtaki, et al.; J. Biol. Chem. 274, 37041 (1999) Abstract; Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat: A. Jureus, et al.; Endocrinology 141, 2703 (2000) Abstract; Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain: J.A. Larm & A.L. Gundlach; Neuroendocrinology 72, 67 (2000) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-021 Revised 25-Sep-06
Ghrelin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-157-021-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-021-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C149H249N47O42
MW: 3370.9
CAS NUMBER: 258279-04-8
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in distilled water or 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on the cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-157-022 Revised 25-Sep-06
Ghrelin (rat)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-157-022-MC05   0.5 mg 230.00 USD Add To Cart
ALX-157-022-M001   1 mg 390.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
FORMULA: C147H244N45O42
MW: 3313.8
CAS NUMBER: 258338-12-4
PURITY: ≥98%
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Ghrelin, a 28 aa peptide predominantly produced by the stomach, is an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) that potently stimulates growth hormone release. Recent studies suggest that peripherally or centrally administrated ghrelin, independent of growth hormone, decreases fat oxidation and increases food intake and adiposity. In addition, plasma ghrelin levels are lower in obese human subjects. Ghrelin promotes the production of orexigenic neuropeptides (neuropeptide Y and agouti-related protein) in the hypothalamic arcuate nuclei and activates the neurons which produce these orexigenic neuropeptides, resulting in an increase in feeding and body weight and thereby opposing the effects of leptin. Moreover, ghrelin shows regulatory effects on th cardiovascular and immune system.
Product Specific Literature References
Ghrelin is a growth-hormone-releasing acylated peptide from stomach: M. Kojima, et al.; Nature 402, 656 (1999) Abstract
Ghrelin: a step forward in the understanding of somatotroph cell function and growth regulation: C. Dieguez & F.F. Casanueva; Eur. J. Endocrinol. 142, 413 (2000) Abstract; Full Text
(Ghrelin and immunity: a young player in an old field: V.D. Dixit & D.D. Taub; Exp. Gerontol. 40, 900 (2005), (Review) Abstract
Ghrelin: structure and function: M. Kojima & K. Kangawa; Physiol. Rev. 85, 495 (2005), (Review) Abstract
Developments in ghrelin biology and potential clinical relevance: R.G. Smith, et al.; Trends Endocrinol. Metab. 16, 436 (2005), (Review) Abstract
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Peptides
 
 
ALX-163-003 Revised 06-Jun-03
NPY (human)
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SYNONYMS Neuropeptide Y (human)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Modulators
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ALX-163-003-PC05   0.5 mg* 140.00 USD Add To Cart
ALX-163-003-P001   1 mg* 250.00 USD Add To Cart
Product Specification
SEQUENCE: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
FORMULA: C189H285N55O57S
MW: 4271.7
CAS NUMBER: 90880-35-6
MERCK INDEX: 14: 6485
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Cloning, characterization, and DNA sequence of a human cDNA encoding neuropeptide tyrosine: C.D. Minth, et al.; PNAS 81, 4577 (1984) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Peptides • Leptin / Related Products
 
 
ALX-164-001 Revised 06-Jan-06
Orexin A (human, bovine, rat, mouse)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-001-C100   100 µg 120.00 USD Add To Cart
ALX-164-001-C500   500 µg 370.00 USD Add To Cart
ALX-164-001-M001   1 mg 690.00 USD Add To Cart
Product Specification
SEQUENCE: Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
(Disulfide bonds between Cys6-Cys12 and Cys7-Cys14).
FORMULA: C152H243N47O44S4
MW: 3561.2
PURITY: ≥98%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Hypothalamic neuropeptide that stimulates food intake in rats with impressive potency. Binds specifically to the OX1 receptor.
Product Specific Literature References
Orexins and orexin receptors: a family of hypotalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Peptides
 
 
ALX-164-002 Revised 06-Jan-06
Orexin B (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-002-C100   100 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
FORMULA: C122H212N44O34S
MW: 2871.4
PURITY: ≥95%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Like orexin A (Prod. No. ALX-164-001), orexin B is a hypothalamatic neuropeptide stimulating food intake in rats. Stimulates food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX1 receptor is significantly lower than that of orexin A. Binding affinities for the OX2 receptor are similar for orexin A and B.
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Peptides
 
 
ALX-164-003 Revised 10-Jun-03
Orexin B (rat, mouse)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Orexins / Related Products
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ALX-164-003-C100   100 µg 150.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
FORMULA: C125H215N45O33S
MW: 2908.5
PURITY: ≥97%
FORMULATION: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Specific Literature References
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior: T. Sakurai, et al.; Cell 92, 573 (1998) Abstract
Orexins and appetite: the big picture of energy homeostasis gets a little bigger: M.W. Schwartz; Nature Medicine 4, 385 (1998) Abstract
Further Categories Containing This Product:
Neuropeptides & Receptors Other Products • Peptides
 
 
ALX-164-004 Revised 04-Jul-08
Obestatin (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-164-004-M001   1 mg 130.00 USD Add To Cart
ALX-164-004-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Val-Gln-Tyr-Gln-Gln-His-Ser-Gln-Ala-Leu-NH2
FORMULA: C116H176N32O33
MW: 2546.9
PEPTIDE CONTENT: ≥80%
PURITY: ≥97% (HPLC)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005) Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-164-005 Revised 04-Jul-08
Obestatin (mouse, rat)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Ghrelin / Related Products
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ALX-164-005-M001   1 mg 130.00 USD Add To Cart
ALX-164-005-M005   5 mg 480.00 USD Add To Cart
Product Specification
SEQUENCE: H-Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
FORMULA: C114H174N34O31
MW: 2516.8
PEPTIDE CONTENT: ≥80%
PURITY: ≥97% (HPLC)
FORMULATION: Lyophilized.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Obestatin derives like ghrelin from proghrelin, but exhibits opposite physiological effects. Obestatin decreases food intake and body weight in rodents. Moreover, obestatin also counteracts ghrelin’s effect by decelerating gastric emptying and decreasing intestinal contractility. Obestatin binds to orphan G protein-coupled receptor GPR39. Amidation of the C-terminus seems to be important for obestatin’s activity.
Product Specific Literature References
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin’s effects on food intake: J.V. Zhang, et al.; Science 310, 996 (2005) Abstract
Biomedicine. Separation of conjoined hormones yields appetite rivals: R. Nogueiras & M. Tschop; Science 310, 985 (2005), (Comment) Abstract
 
 
ALX-165-052 Revised 04-Mar-05
Peptide YY (3-36) (human)
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PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Food Intake Modulators Other Products
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ALX-165-052-C500   500 µg 130.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
FORMULA: C180H279N53O54
MW: 4049.5
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
FORMULATION: Lyophilized. TFA salt.
SOLUBILITY: 5mg/ml soluble in distilled water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Y2R agonist, inhibiting food intake and reducing weight gain in rats and humans after peripheral injection.
Product Specific Literature References
Gut hormone PYY(3-36) physiologically inhibits food intake: R.L. Batterham, et al.; Nature 418, 650 (2002) Abstract
Further Categories Containing This Product:
Peptides
 
 
ALX-201-034 Revised 02-May-06
Leptin (human) (recombinant)
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SYNONYMS OB Gene Product (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Leptin / Related Products
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ALX-201-034-M001   1 mg 190.00 USD Add To Cart
Product Specification
MW: ~16kDa.
MERCK INDEX: 14: 5443
SOURCE/HOST: Produced in E. coli. Homologous to human serum leptin.
PURITY: ≥98% (SDS-PAGE)
FORMULATION: Lyophilized from sterile filtered solution in 10mM sodium citrate, pH 4.0.
ENDOTOXIN CONTENT: