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Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
You are here: Product Lines > Inflammation > Anti-inflammatory Agents > Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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Items 16 of 16
ALX-430-110 Revised 16-Jan-08
5-Aminosalicylic acid
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SYNONYMS 5-ASA
Mesalamine
5-Amino-2-hydroxybenzoic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NF-kB Pathway Inhibitors
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ALX-430-110-G005   5 g 20.00 USD Add To Cart
Product Specification
FORMULA: C7H7NO3
MW: 153.1
CAS NUMBER: 89-57-6
MERCK INDEX: 14: 5904
PURITY: ≥98%
SOLUBILITY: Soluble in 1 M hydrochloric acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Inhibits TNF-α regulated IκB degradation and NF-κB activation.
Product Specific Literature References
Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine: S. Liptay, et al.; Br. J. Pharmacol. 128, 1361 (1999) Abstract
Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells: F. Yan & D.B. Polk; J. Biol. Chem. 274, 36631 (1999) Abstract; Full Text
Further Categories Containing This Product:
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-380-126 Revised 17-Jul-08 New product
Asperloxine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-126-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C21H19N3O5
MW: 393.4
SOURCE/HOST: Isolated from Aspergillus ochraceus.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR.

Product Description

Natural benzodiazepine. Anti-inflammatory.
Product Specific Literature References
Big effects from small changes: possible ways to explore nature’s chemical diversity: H.B. Bode, et al.; Chembiochem. 3, 619 (2002) Abstract
Further Categories Containing This Product:
Benzodiazepines / Related Products • Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
 
 
ALX-430-115 Revised 14-Aug-08
Aspirin
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SYNONYMS Acetylsalicylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-115-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C9H8O4
MW: 180.2
CAS NUMBER: 50-78-2
MERCK INDEX: 14: 851
RTECS: VO0700000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol (80mg/ml), DMSO (41mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (2.7mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 2 years when stored at room temperature. Keep aqueous solutions on ice and use within 30 minutes. Unstable in basic solutions pH>7.4.
HAZARD: HARMFUL.

Product Specific Literature References
Inhibition of NF-kappa B by sodium salicylate and aspirin: E. Kopp & S. Ghosh; Science 265, 956 (1994) Abstract
Neuroprotection by aspirin and sodium salicylate through blockade of NF- kappaB activation: M. Grilli, et al.; Science 274, 1383 (1996) Abstract
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta: M.J. Yin, et al.; Nature 396, 77 (1998) Abstract
The pleiotropic functions of aspirin: mechanisms of action: A.R. Amin, et al.; Cell Mol. Life Sci. 56, 305 (1999) Abstract
Further Categories Containing This Product:
COX Inhibitors • NF-kB Pathway Inhibitors • Antithrombotic Agents / Related Products
 
 
ALX-550-249 Revised 27-May-03
Ibuprofen
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SYNONYMS α-Methyl-4-(2-methylpropyl)benzeneacetic acid
(±)-2-(4-Isobutylphenyl)propionic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-550-249-G001   1 g 17.00 USD Add To Cart
ALX-550-249-G005   5 g 48.00 USD Add To Cart
Product Specification
FORMULA: C13H18O2
MW: 206.3
CAS NUMBER: 15687-27-1
MERCK INDEX: 14: 4881
PURITY: ≥99%
APPEARANCE: White solid.
SOLUBILITY: Soluble in methanol or dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Selective cyclooxygenase (COX) inhibitor.
Product Specific Literature References
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction: R.F. Myers & M.I. Siegel; BBRC 112, 586 (1983) Abstract
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition: M. Rampart & T.J. Williams; Biochem. Pharmacol. 35, 581 (1986) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-270-086 Revised 07-May-08
Indomethacin
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-086-G005   5 g 30.00 USD Add To Cart
ALX-270-086-G025   25 g 80.00 USD Add To Cart
Product Specification
FORMULA: C19H16ClNO4
MW: 357.8
CAS NUMBER: 53-86-1
MERCK INDEX: 14: 4968
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in acetone or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: VERY TOXIC.

Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors
 
 
ALX-270-102 Revised 10-Aug-07
Naproxen
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SYNONYMS (S)-6-Methoxy-α-methyl-2-naphthalene acetic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-102-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C14H14O3
MW: 230.3
CAS NUMBER: 22204-53-1
MERCK INDEX: 14: 6417
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide and 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.

Product Description
Cyclooxygenase (COX) inhibitor. Widely used non-steroidal anti-inflammatory drug.
Product Specific Literature References
Perspectives in nonsteroidal anti-inflammatory agents: T.Y. Shen; Angew. Chem. Int. Ed. 11, 460 (1972) Abstract
Further Categories Containing This Product:
PPAR Agonists • COX Inhibitors
 
 
ALX-270-196 Revised 12-Sep-05
Niflumic acid
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SYNONYMS Nifluril
2-[[3-(Trifluoromethyl)phenyl]-amino]-3-pyridinecarboxylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-196-G005   5 g 26.00 USD Add To Cart
Product Specification
FORMULA: C13H9F3N2O2
MW: 282.2
CAS NUMBER: 4394-00-7
MERCK INDEX: 14: 6531
PURITY: ≥99%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2).
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-270-193 Revised 04-Mar-05
Nimesulide
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SYNONYMS N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-193-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O5S
MW: 308.3
CAS NUMBER: 51803-78-2
MERCK INDEX: 14: 6548
PURITY: ≥99%
APPEARANCE: Light tan crystals.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2): R. Huff, et al.; Inflamm. Res. 44, S145 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers) • COX Inhibitors
 
 
ALX-270-197 Revised 15-Jan-08
NS-398
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SYNONYMS N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-197-M005   5 mg 55.00 USD Add To Cart
ALX-270-197-M010   10 mg 98.00 USD Add To Cart
ALX-270-197-M050   50 mg 395.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O5S
MW: 314.4
CAS NUMBER: 123653-11-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white crystalline solid
SOLUBILITY: Soluble in 100% ethanol (warm; sonification), DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent and selective cyclooxygenase-2 (COX-2) inhibitor.
Product Specific Literature References
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats: I. Arai, et al.; Res. Comm. Chem. Pathol. Pharmacol. 81, 259 (1993) Abstract
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions: N. Futaki, et al.; Gen. Pharmacol. 24, 105 (1993) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms: M. Ouellet & M.D. Percival; Biochem. J. 306, 247 (1995) Abstract
Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism: M.C. Zatelli, et al.; J. Clin. Endocrinol. Metab. 90, 5754 (2005) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-430-112 Revised 20-Aug-03
Phenylbutazone
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SYNONYMS 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-112-G005   5 g 10.00 USD Add To Cart
Product Specification
FORMULA: C19H20N2O2
MW: 308.4
CAS NUMBER: 50-33-9
MERCK INDEX: 14: 7277

Product Description
Anti-inflammatory agent. Substrate for prostaglandin peroxidase.
Further Categories Containing This Product:
Prostaglandins Other Products
 
 
ALX-430-040 Revised 18-Feb-03
Piroxicam
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-040-G001   1 g 40.00 USD Add To Cart
ALX-430-040-G005   5 g 180.00 USD Add To Cart
Product Specification
FORMULA: C15H13N3O4S
MW: 331.4
CAS NUMBER: 36322-90-4
MERCK INDEX: 14: 7506
PURITY: ≥99%
APPEARANCE: Yellowish solid.
SOLUBILITY: Soluble in DMSO or chloroform.