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K+ Channel Antibodies
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ALX-804-652 Revised 22-Feb-07
Monoclonal Antibody to HERG1 (human) (A12)
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SYNONYMS anti-Erg1 (human) MAb (A12)
anti-Ether-a-go-go Related Protein 1 (human) MAb (A12)
anti-KCNH2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (human) MAb (A12)
anti-Voltage-gated Potassium Channel Kv11.1 (human) MAb (A12)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-652-R300   300 µl 390.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: A12
ISOTYPE: Mouse IgG2b
FORMULATION: Liquid. Ascites.
IMMUNOGEN: Synthetic peptide corresponding to aa 575-588 (E575QPHMDSRIGWLHN588) of the extracellular loop S5-P of HERG1 (human ether-a-go-go related protein 1).
SPECIFICITY: Recognizes the extracellular loop S5-P of HERG1.
APPLICATION: Flow Cytometry (1:2-1:50)
Immunocytochemistry (1:50-1:200)
Immunohistochemistry (paraffin sections) (1:50-1:200)
Immunoprecipitation (3-5µl)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Monoclonal Antibodies
 
 
ALX-215-049 Revised 21-Aug-08
Polyclonal Antibody to HERG1 (CT) (pan)
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SYNONYMS anti-Erg1 (CT) (pan) PAb
anti-Ether-a-go-go Related Protein 1 (CT) (pan) PAb
anti-KCNH2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (CT) (pan) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (CT) (pan) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-049-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).
SPECIFICITY: Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.
APPLICATION: Flow Cytometry (1:1'000)
Immunocytochemistry (1:100-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008) Abstract
General Information

The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-050 Revised 22-Feb-07
Polyclonal Antibody to HERG1A (NT)
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SYNONYMS anti-Erg1A (NT) PAb
anti-Ether-a-go-go Related Protein 1A (NT) PAb
anti-KCNH2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform A) (NT) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform A) (NT) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-050-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum.
IMMUNOGEN: Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).
SPECIFICITY: Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
Immunoprecipitation (5µl/1.5mg protein)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000) Abstract
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003) Abstract; Full Text
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-052 Revised 01-Jun-07
Polyclonal Antibody to HERG2
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SYNONYMS anti-Erg2 PAb
anti-Ether-a-go-go Related Protein 2 PAb
anti-KCNH6 PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 6 PAb
anti-Voltage-gated Potassium Channel Kv11.2 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-052-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Recombinant human HERG2 (ether-a-go-go related protein 2) (aa 907-986).
SPECIFICITY: Recognizes HERG2 and mouse Erg2.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
General Information

The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-053 Revised 01-Jun-07
Polyclonal Antibody to HERG3
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SYNONYMS anti-Erg3 PAb
anti-Ether-a-go-go Related Protein 3 PAb
anti-KCNH7 PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 7 PAb
anti-Voltage-gated Potassium Channel Kv11.3 PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-053-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein A-affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Recombinant HERG3 (human ether-a-go-go related protein 3) (aa 1115-1194).
SPECIFICITY: Recognizes HERG3 and mouse Erg3.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
ALX-215-051 Revised 24-Jun-08
Polyclonal Antibody to HERG1B
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SYNONYMS anti-Erg1B PAb
anti-Ether-a-go-go Related Protein 1B PAb
anti-KCNH2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Subfamily H Member 2 (Isoform B) PAb
anti-Voltage-gated Potassium Channel Kv11.1 (Isoform B) PAb
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY K+ Channel Antibodies
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-215-051-R100   100 µl 270.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
PURITY DETAIL: Affinity purified.
FORMULATION: Liquid. In 100mM TRIS containing 100mM glycine.
IMMUNOGEN: Synthetic peptide corresponding to aa 15-28 (R15PRAQKGRVRRAVR28) of HERG1B (human ether-a-go-go related protein 1B).
SPECIFICITY: Recognizes HERG1B and mouse Erg1B isoform.
APPLICATION: Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections) (1:100)
Western Blot (1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005) Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005) Abstract
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005) Abstract
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. Epub ahead of print, (2008) Abstract
General Information
The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
Further Categories Containing This Product:
Cancer Other Products • Polyclonal Antibodies
 
 
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