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ALX-450-005 Revised 04-Feb-05
INDO 1/AM
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SYNONYMS 1-[2-Amino-5-(6-carboxyindol-2-yl)phenoxy]-2-(2'-amino-5'-methylphenoxy)ethane-N,N,N',N'-tetraacetic acid, pentaacetoxymethylester
PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes
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ALX-450-005-M001   1 mg 130.00 USD Add To Cart
ALX-450-005-M005   5 mg 520.00 USD Add To Cart
Product Specification
FORMULA: C47H51N3O22
MW: 1009.9
CAS NUMBER: 112926-02-0
PURITY: ≥97%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable analog of INDO 1 (Prod. No. ALX-450-004). Fluorescent probe for Ca2+. After crossing the membrane, the product is rapidly hydrolyzed by cytoplasmic esterases to the membrane impermeant INDO 1.
Product Specific Literature References
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures: R.Y. Tsien; Biochemistry 19, 2396 (1980) Abstract
A new generation of Ca2+ indicators with greatly improved fluorescence properties: G. Grynkiewicz, et al.; J. Biol. Chem. 260, 3440 (1985) Abstract; Full Text
Measuring cytosolic free calcium concentration in endothelial cells with indo-1: the pitfall of using the ratio of two fluorescence intensities recorded at different wavelengths: A. Luckhoff; Cell Calcium 7, 233 (1986) Abstract
Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: analysis with indo-1: M.K. Bijsterbosch, et al.; BBRC 137, 500 (1986) Abstract
Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry: P.S. Rabinovitch, et al.; J. Immunol. 137, 952 (1986) Abstract
Cytosolic and vacuolar Ca2+ concentrations in yeast cells measured with the Ca2+-sensitive fluorescence dye indo-1: D. Halachmi & Y. Eilam; FEBS Lett. 256, 55 (1989) Abstract
Calcium mobilization in human platelets using indo-1 and flow cytometry: L.K. Jennings, et al.; Blood 74, 2674 (1989) Abstract
Analysis of cytosolic ionized calcium variation in polymorphonuclear leukocytes using flow cytometry and Indo-1 AM: M. Lopez, et al.; Cytometry 10, 165 (1989) Abstract
Intracellular Ca2+ measurement with Indo-1 in substrate-attached cells: advantages and special considerations: M. Wahl, et al.; Cell Calcium 11, 487 (1990) Abstract
Calcium homeostasis in dissociated embryonic neurons: a flow cytometric analysis: J.P. Grierson, et al.; J. Neurophysiol. 67, 704 (1992) Abstract
Further Categories Containing This Product:
MDR Other Products • Calcium Indicators / Probes • Calcium Chelators / Caged Calcium Chelators
 
 
ALX-420-011 Revised 12-Jan-07
(-)-Indolactam V
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Activators
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ALX-420-011-C300   300 µg 110.00 USD Add To Cart
ALX-420-011-M001   1 mg 250.00 USD Add To Cart
Product Specification
FORMULA: C17H23N3O2
MW: 301.4
CAS NUMBER: 90365-57-4
RTECS: UY8547000
PURITY: ≥95% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL. MAY BE CARCINOGENIC.
IDENTITY: May contain traces of (+)-Indolactam V.

Product Description
Moderately potent indolactam activator of protein kinase C (PKC). Increases cytoplasmic mRNAs.
Product Specific Literature References
Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann 75, 866 (1984) Abstract
(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC 162, 1207 (1989) Abstract
Interleukin-4 signals regulating CD23 gene expression in human B cells: protein kinase C-independent signaling pathways: C.E. Lee, et al.; Cell Immunol. 146, 171 (1993) Abstract
Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay: H.L. Shieh, et al.; Mol. Carcinogen. 12, 166 (1995) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products
 
 
ALX-350-347 Revised 05-Aug-08
Indole-3-carbinol
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SYNONYMS I3C
Indole-3-methanol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-347-M250   250 mg 40.00 USD Add To Cart
ALX-350-347-G001   1 g 90.00 USD Add To Cart
Product Specification
FORMULA: C9H9NO
MW: 147.2
CAS NUMBER: 700-06-1
RTECS: NL9483000
PURITY: ≥98% (HPLC)
APPEARANCE: White to light yellow solid.
SOLUBILITY: 50mg/ml soluble in DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Anticancer agent. Inhibits carcinogenesis at the initiation stage but has been shown to enhance tumor incidence at a post-initiation stage. Inhibits the expression of cyclin-dependent kinase 6 (CDK6) and induces G1 cell cycle arrest independent of estrogen receptor signalling. Causes a dose-dependent increase in E-cadherin and BRCA1 expression.
Product Specific Literature References
Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles: L.W. Wattenberg & W.D. Loub; Cancer Res. 38, 1410 (1978) Abstract
Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling: C.M. Cover, et al.; J. Biol. Chem. 273, 3838 (1998) Abstract; Full Text
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes: Q. Meng, et al.; J. Mol. Med. 78, 155 (2000) Abstract; Full Text
Therapeutic intervention of experimental breast cancer bone metastasis by indole-3-carbinol in SCID-human mouse model: K.M. Rahman, et al.; Mol. Cancer Ther. 5, 2747 (2006) Abstract; Full Text
3,3’-Diindolylmethane stimulates murine immune function in vitro and in vivo: L. Xue, et al.; J. Nutr. Biochem. 19, 336 (2008) Abstract
Related Products
Further Categories Containing This Product:
Natural Products for Cell Cycle Research • Cell Cycle Blockers & Inhibitors / Related Products • Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-270-086 Revised 07-May-08
Indomethacin
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-086-G005   5 g 30.00 USD Add To Cart
ALX-270-086-G025   25 g 80.00 USD Add To Cart
Product Specification
FORMULA: C19H16ClNO4
MW: 357.8
CAS NUMBER: 53-86-1
MERCK INDEX: 14: 4968
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in acetone or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: VERY TOXIC.

Product Description
Non-steroidal anti-inflammatory and analgesic agent. Inhibits prostaglandin synthesis. Far more potent for inhibition of cyclooxygenases (COX) than for inhibition of lipoxygenases.
Product Specific Literature References
Chemical and biological studies on indomethacin, sulindac and their analogs: T.Y. Shen, et al.; Adv. Drug Res. 12, 90 (1977) Abstract
Comparative effects of indomethacin, acetylenic acids, 15-HETE, nordihydroguaiaretic acid and BW755C on the metabolism of arachidonic acid in human leukocytes and platelets: H. Salari, et al.; Prostagl. Leukotr. Med. 13, 53 (1984) Abstract
Effects of indomethacin on fetal renal function, renal and umbilicoplacental blood flow and lung liquid production: K.M. Stevenson & E.R. Lumbers; J. Dev. Physiol. 17, 257 (1992) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • COX Inhibitors
 
 
ALX-350-032 Revised 08-Oct-08
Ingenol 3,20-dibenzoate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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ALX-350-032-M001   1 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C34H36O7
MW: 556.7
CAS NUMBER: 59086-90-7
SOURCE/HOST: Semisynthetic.
PURITY: ≥96%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC.

Product Description
Activates protein kinase C (PKC). Induces apoptosis. Anticancer agent. Shows potent antileukemic activity in the P388 mouse assay. Displays unusually high mouse ear inflammatory activity, even though the 20-hydroxy group is blocked with a benzoate ester. It appears likely that this high potency is due to metabolic cleavage of the 20-benzoate group, which releases the more potent ingenol 3-benzoate.
Product Specific Literature References
Antileukemic principles isolated from euphorbiaceae plants: S.M. Kupchan, et al.; Science 191, 571 (1976) Abstract
Zur Chemie des Ingcnols, II. Ester des Ingenols. und des A’-’-Isoingenols: B. Sorg & E. Hecker; Z. Naturforsch. 37b, 748 (1982)
Induction of thymocyte apoptosis by Ca2+-independent protein kinase C (nPKC) activation and its regulation by calcineurin activation: A. Asada, et al.; J. Biol. Chem. 273, 28392 (1998) Abstract
Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway: M. Blanco-Molina, et al.; Chem. Biol. Interact. 8, 767 (2001) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Antitumor Agents (Apoptosis Inducers) • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antitumor Reagents
 
 
ALX-430-139 Revised 20-Feb-08
Irinotecan . hydrochloride . trihydrate
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SYNONYMS Camptosar
7-ethyl-10-hydroxycamptothecin
CPT-11
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Topoisomerase Inhibitors
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ALX-430-139-M005   5 mg 90.00 USD Add To Cart
ALX-430-139-M025   25 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C33H38N4O6 . HCl . 3H2O
MW: 586.7 . 36.4 . 54.0
CAS NUMBER: 100286-90-6; 136572-09-3
MERCK INDEX: 14: 5091
PURITY: ≥98% (HPLC)
APPEARANCE: Pale yellow powder.
SOLUBILITY: Slightly soluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.
Product Specific Literature References
Induction of tumor necrosis factor by a camptothecin derivative, irinotecan, in mice and human mononuclear cells: S. Goto, et al.; Anticancer Res. 16, 2507 (1996) Abstract
The role of irinotecan in colorectal cancer: L.B. Saltz; Curr. Oncol. Rep. 1, 155 (1999) Abstract
Therapeutic advances in small cell lung cancer: F.P. Worden and G.P. Kalemkerian; Expert Opin. Investig. Drugs 9, 565 (2000) Abstract
Human DNA-Topoisomerases - Diagnostic and Therapeutic Implications for Cancer: U. Kellner, et al.; Onkologie 23, 424 (2000) Abstract
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis: Y. Takeba, et al.; J. Pharmacol. Sci. 104, 232 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-350-145 Revised 28-Mar-07
Isobavachalcone
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SYNONYMS 2’,4’,4-Trihydroxy-3’-[3’’-methylbut-3’’-enyl]chalcone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-145-M001   1 mg 190.00 USD Add To Cart
Product Specification
FORMULA: C20H20O4
MW: 324.4
CAS NUMBER: 20784-50-3
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Shows antifungal activity.
Product Specific Literature References
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects: T. Akihisa, et al.; Cancer Lett. 201, 133 (2003) Abstract
Antitrichomonal and antioxidant activities of Dorstenia barteri and Dorstenia convexa: N.O. Omisore, et al.; Braz. J. Med. Biol. Res. 38, 1087 (2005) Abstract
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects: T. Akihisa, et al.; J. Nat. Prod. 69, 38 (2006) Abstract
Inhibition of matrix metalloproteinase-2 secretion by chalcones from the twigs of Dorstenia barteri Bureau.: B. Ngameni, et al.; Arkivoc ix, 91 (2007) Full Text
Further Categories Containing This Product:
Other Natural Products - DNA Regulation / Transcription • Antitumor Agents (Anti-proliferative) • Chalcones • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • MMP Inhibitors • Epstein Barr Virus / Related Products • Natural Products - Antifungal Agents
 
 
ALX-385-025 Revised 07-Apr-08
8-Isopentenylnaringenin
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SYNONYMS 8-Prenylnaringenin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-025-M005   5 mg 155.00 USD Add To Cart
Product Specification
FORMULA: C20H20O5
MW: 340.4
SOURCE/HOST: Isolated from hops (Humulus lupulus L.).
PURITY: ≥97% (HPLC)
APPEARANCE: Light yellow powder
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenyl flavonoid. Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent inhibitor of angiogenesis in vitro and in vivo. Chemopreventive agent against cancer induced by heterocyclic amines.
Product Specific Literature References
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship: M. Kitaoka, et al.; Planta Med. 64, 511 (1998) Abstract
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism: M. Miyamoto, et al.; Planta Med. 64, 516 (1998) Abstract
Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 84, 2249 (1999) Abstract
Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2: C.L. Miranda, et al.; Drug Metab. Dispos. 28, 1297 (2000) Abstract; Full Text
The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 85, 4912 (2000) Abstract; Full Text
8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo: M.S. Pepper, et al.; J. Cell Physiol. 199, 98 (2004) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types: T.F. Bovee, et al.; J. Steroid Biochem. Mol. Biol. 91, 99 (2004) Abstract
8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells: E. Brunelli, et al.; J. Steroid Biochem. Mol. Biol. 107, 140 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors / Related Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Other Natural Products - DNA Regulation / Transcription
 
 
ALX-385-024 Revised 06-Oct-08
Isorhamnetin
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SYNONYMS 3-Methylquercetin
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-024-M005   5 mg 90.00 USD Add To Cart
ALX-385-024-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O7
MW: 316.3
CAS NUMBER: 480-19-3
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone, methanol, ethylacetate or DMSO. Only sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: