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ALX-350-131 Revised 03-Apr-08
Chaetoglobosin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-131-M001   1 mg 40.00 USD Add To Cart
ALX-350-131-M005   5 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C32H36N2O5
MW: 528.7
SOURCE/HOST: Isolated from Chaetomium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in methanol; almost unsoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR.

Product Description
Cytochalasin analog with anti-fungal activity. Phytotoxic and anti-bacterial activity. Exhibits cytotoxic effects against human cancer cell lines. Enhances fibrinolytic activity of bovine aortic endothelial cells.
Product Specific Literature References
Acute toxic effects of chaetoglobosin A, a new cytochalasan compound produced by Chaetomium globosum, on mice and rats: K. Ohtsubo, et al.; Jpn. J. Exp. Med. 48, 105 (1978) Abstract
Chaetoglobosins, cytotoxic 10-(indol-3-yl)-[13]cytochalasans from Chaetomium spp. I. Production, isolation and some cytological effects of chaetoglobosins A-J: S. Sekita, et al.; Chem. Pharm. Bull. 30, 1609 (1982) Abstract
Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B: C. Shinohara, et al.; J. Antibiot. 53, 262 (2000) Abstract
Phytotoxic chaetoglobosins are produced by the plant pathogen Calonectria morganii (anamorph Cylindrocladium scoparium): C. Von Wallbrunn, et al.; J. Gen. Appl. Microbiol. 47, 33 (2001) Abstract; Full Text
Chaetoglobosins Q, R, and T, three further new metabolites from Chaetomium globosum: W. Jiao, et al.; J. Nat. Prod. 67, 1722 (2004) Abstract
Growth and mycotoxin production by Chaetomium globosum: M.R. Fogle, et al.; Mycopathologia 164, 49 (2007) Abstract
Further Categories Containing This Product:
Antitumor Antibiotics
 
 
ALX-380-073 Revised 12-Oct-07
Chartreusin
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SYNONYMS Lambdamycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-073-M005   5 mg 50.00 USD Add To Cart
ALX-380-073-M025   25 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C32H32O14
MW: 640.6
CAS NUMBER: 6377-18-0
MERCK INDEX: 14: 2045
SOURCE/HOST: Isolated from Streptomyces chartreusis.
PURITY: ≥98%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
Product Description
Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents.
Product Specific Literature References
Chartreusin, a New Antibiotic Produced by Streptomyces chartreusis, a New Species: B. E. Leach, et al.; J. Am. Chem. Soc. 75, 4011 (1953)
Chartreusin, a glycosidic antitumour antibiotic from Streptomyces: J.A. Beisler; Prog. Med. Chem. 19, 247 (1982), (Review) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B.H. Long; Eur. J. Cancer 14, 1985 (1993) Abstract
Chartreusin, elsamicin A and related anti-cancer antibiotics: J. Portugal; Curr. Med. Chem. Anticancer Agents 3, 411 (2003), Review Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antibiotics - Topoisomerase Inhibitors • Antitumor Agents (DNA Interaction & Gene Regulation)
 
 
ALX-350-128 Revised 03-Apr-08
Chetomin
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SYNONYMS Chaetomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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ALX-350-128-M001   1 mg 185.00 USD Add To Cart
ALX-350-128-M005   5 mg 495.00 USD Add To Cart
Product Specification
FORMULA: C31H30N6O6S4
MW: 710.9
CAS NUMBER: 1403-36-7
SOURCE/HOST: Isolated from Chaetomium species.
PURITY: ≥98% (HPLC)
APPEARANCE: Off-white to fawn solid.
SOLUBILITY: Soluble in DMSO, ethyl acetate or pyridine; fairly soluble in methanol, 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.
IDENTITY: Determined by 1H-NMR.

Product Description
Dithiodiketopiperazine inhibitor of HIF-1 formation by disrupting the binding of p300 to both HIF-1α and HIF-2α. Inhibitor of tumor growth. Potent immunosuppressor. Antibacterial.
Product Specific Literature References
The structure of chetomin: A.G. McInnes, et al.; JACS 98, 6741 (1976) Abstract
Effects of chetomin on growth and acidic fermentation products of rumen bacteria: W.C. Jen and G.A. Jones; Can. J. Microbiol. 29, 1399 (1983) Abstract
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway: A.L. Kung, et al.; Cancer Cell 6, 33 (2004) Abstract
Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum: H. Fujimoto, et al.; J. Nat. Prod. 67, 98 (2004) Abstract
Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells: A. Staab, et al.; BMC Cancer 7, 213 (2007) Abstract; Full Text
Further Categories Containing This Product:
Immunomodulators Other Products • Hypoxia-inducible Factor [HIF]/Related Products • Antitumor Agents (Anti-proliferative) • Antitumor Antibiotics
 
 
ALX-400-049 Revised 14-Nov-07
Chlorambucil
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SYNONYMS 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (DNA Interaction & Gene Regulation)
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ALX-400-049-G001   1 g 45.00 USD Add To Cart
ALX-400-049-G005   5 g 180.00 USD Add To Cart
ALX-400-049-M250   250 mg 25.00 USD Add To Cart
Product Specification
FORMULA: C14H19Cl2NO2
MW: 304.2
CAS NUMBER: 305-03-3
MERCK INDEX: 14: 2073
RTECS: ES7525000
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in ether or ethanol:chloroform:acetone (3:5:4) (warm); practically insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC. MAY BE CARCINOGENIC.

Product Description
A nitrogen mustard bifunctional alkylating agent. Shows antineoplastic and immunosuppressant effect. Induces apoptosis in chronic lymphocytic leukemia cells.
Product Specific Literature References
DNA damage and mutagenesis induced by nitrogen mustards: L.F. Povirk & D.E. Shuker; Mutat. Res. 318, 205 (1994) Abstract
Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress: I. Boldogh, et al.; Toxicology 193, 137 (2003) Abstract
Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase: L. Amrein, et al.; J. Pharmacol. Exp. Ther. 321, 848 (2007) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
 
 
ALX-480-029 Revised 30-Nov-04
8-Chloroadenosine 3',5'-Cyclic Monophosphate . sodium salt
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SYNONYMS 8-Cl-cAMP . Na
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
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ALX-480-029-M001   1 mg 27.00 USD Add To Cart
ALX-480-029-M005   5 mg 108.00 USD Add To Cart
Product Specification
FORMULA: C10H11ClN5O6P . Na
MW: 363.7 . 23.0
CAS NUMBER: 41941-56-4
PURITY: ≥98%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water. May produce hazy solutions.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
cAMP analog with high selectivity for cAMP-dependent protein kinase type I. Induces growth inhibition and differentiation in cultured cancer cell lines.
Product Specific Literature References
Selective modulation of protein kinase isozymes by the site-selective analog 8-chloroadenosine 3',5'-cyclic monophosphate provides a biological means for control of human colon cancer cell growth: S. Ally, et al.; PNAS 85, 6319 (1988) Abstract
Further Categories Containing This Product:
Antitumor Reagents Other Products
 
 
ALX-350-353 Revised 16-Jun-08 New product
Chlorogenic acid
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SYNONYMS 1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Chemopreventive Agents
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ALX-350-353-M500   500 mg 35.00 USD Add To Cart
ALX-350-353-G001   1 g 65.00 USD Add To Cart
Product Specification
FORMULA: C16H18O9
MW: 354.3
CAS NUMBER: 327-97-9
MERCK INDEX: 14: 2142
RTECS: GU8480000
SOURCE/HOST: Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: 25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: We do not recommend storing the aqueous solution for more than one day.

Product Description
Analog of caffeic acid (Prod. No. ALX-270-231). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]: R. Krasemann; Arch. Pharm. 293, 721 (1960) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate: M.T. Huang, et al.; Cancer Res. 48, 5941 (1988) Abstract; Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin: A.H. Conney, et al.; Adv. Enzyme Regul. 31, 385 (1991) Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells: G. Bandyopadhyay, et al.; Blood 104, 2514 (2004) Abstract; Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid: R. Feng, et al.; J. Biol. Chem. 280, 27888 (2005) Abstract; Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression: A. Belkaid, et al.; Cancer Cell Int. 6, 7 (2006) Abstract; Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid: M.D. dos Santos, et al.; Biol. Pharm. Bull. 29, 2236 (2006) Abstract; Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols: W.J. Lee & B.T. Zhu; Carcinogenesis 27, 269 (2006) Abstract; Full Text
Related Products
Further Categories Containing This Product:
MAPK Pathway Activators • Natural Products for Neurological Research • Natural Products - Antioxidants • Analgesic/Anti-nociceptive Agents/Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables
 
 
ALX-270-392 Revised 08-Dec-04
3-(2-Chloro-3-indolylmethylene)-1,3-dihydroindol-2-one
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
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ALX-270-392-M001   1 mg 35.00 USD Add To Cart
ALX-270-392-M005   5 mg 130.00 USD Add To Cart
Product Specification
FORMULA: C17H11ClN2O
MW: 294.7
PURITY: ≥95% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for 3 years after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. Protect from light.

Product Description
Selective, ATP-competitive inhibitor of CDK1/cyclin B (IC50=5.8µM) and CDK5 (IC50=25µM). Does not inhibit GSK-3β (IC50>100µM). Exhibits potent antiproliferative properties (IC50=2µM in HeLa cells).
Product Specific Literature References
Potential antitumor agents. 25 [1]. Synthesis and cytotoxic activity of 3-(2-chloro-3-indolylmethylene)1,3-dihydroindol-2-ones: A. Andreani, et al.; Anticancer Res. 16, 3585 (1996) Abstract
Imidazo[2,1 -b]thiazolylmethylene- and indolylmethylene-2-indolinones: a new class of cyclin-dependent kinase inhibitors. Design, synthesis, and CDK1/cyclin B inhibition: A. Andreani, et al.; Anticancer Drug Des. 15, 447 (2000) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Anti-proliferative)
 
 
ALX-270-437 Revised 04-Jun-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins/Related Products
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ALX-270-437-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H13ClN2O
MW: 248.7
CAS NUMBER: 49843-98-3
PURITY: ≥95%
APPEARANCE: White to beige powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Specific cell permeable inhibitor. Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38nM in vitro; compared to hSIRT2: IC50=19µM and hSIRT3: IC50=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC50>100µg). Inhibits the deacetylation of p53 (IC50=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1: A.D. Napper, et al.; J. Med. Chem. 48, 8045 (2005) Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes: J.C. Milne, et al.; Nature 450, 712 (2007) Abstract
Further Categories Containing This Product:
p53 Other Products
 
 
ALX-270-171 Revised 30-Jun-08
Chlorpromazine . hydrochloride
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SYNONYMS 2-Chloro-10-(3-dimethylaminopropyl)phenothiazine . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calmodulin Inhibitors
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-171-G001   1 g 22.00 USD Add To Cart
ALX-270-171-G005   5 g 66.00 USD Add To Cart
Product Specification
FORMULA: C17H19ClN2S . HCl
MW: 318.9 . 36.5
CAS NUMBER: 69-09-0
MERCK INDEX: 14: 2185
RTECS: SO1750000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Not stable in aqueous solution. We strongly recommend always to use freshly prepared solutions.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Inhibits calmodulin stimulation of cyclic nucleotide phosphodiesterase. Dopamine antagonist. D2 antagonist. H1 antagonist. Inhibits TNF-α production. Potent PLA2 inhibitor. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in mouse lung. Antipsychotic.
Product Specific Literature References
Chlorpromazine as a substitute for ortho-dianisidine and ortho-tolidine in the determination of chlorine, hemoglobin, and peroxidase activity: H.B. Collier; Clin. Biochem. 7, 331 (1974) Abstract
Drug-protein interactions: binding of chlorpromazine to calmodulin, ca