Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
> Cancer
14-3-3 Proteins / Related Products
Angiogenesis
Antibiotics for Cancer Research
Antimicrobial Peptides & Proteins / Related Products
Antitumor Reagents
Carcinogens & Tumor Promoters
Cathepsins / Related Products
CD44 / Related Products
CEACAM [CD66] / Related Products
Chemopreventive Agents & Inhibitors of Carcinogenesis
Clusterin / Related Products
Dependence Receptors / Related Products
erbB-2 / Related Products
Matrix Metalloproteinases [MMPs] / Related Products
Multidrug Resistance [MDR]
Natural Products for Cancer Research
Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
p53 / Related Products
Topoisomerases / Related Products
Tumor Markers
Tumor Suppressors / Related Products
Cancer Other Products
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
160-180
of 918
Page 9
of 46
Select Page:
<<
1
2
3
4
5
6
7
8
9
10
>>
ALX-210-763
Revised 14-Dec-05
Polyclonal Antibody to Topoisomerase IIα (human)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
Topoisomerase Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-763-C500
500 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified IgG.
FORMULATION:
Liquid. In 10mM PBS, pH 7.4, containing 0.2% BSA and 0.09% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1513-1530 (R
1513
AKKPIKYLEESDEDDLF
1530
) of C-terminal human topoisomerase IIα.
SPECIFICITY:
Recognizes human topoisomerase IIα. Detects a band of ~170kDa by Western blot. Does not cross-react with topoisomerase IIβ or I.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (frozen sections, paraffin sections)
Immunoprecipitation (use Protein A; 10µg/mg protein lysate)
Western Blot (excellent) (5µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Product Description
Topoisomerase IIα plays important roles in the synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G
2
- and M-phases in transformed and developmentally regulated normal cells. Topoisomerase IIα is also implicated in drug resistance of tumor cells. Note: Ki67 is also present in G
1
-phase.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-768
Revised 11-Apr-06
Polyclonal Antibody to p51A
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
p53 Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-768-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 424-446 (E
424
PRRETPKQSDVFFRHSKPPNRS
446
) of C-terminal human p51A.
SPECIFICITY:
Recognizes human and mouse p51A. Detects a band of ~54kDa by Western blot. Does not cross-react with p51B.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on mouse thymus, mouse heart and human T cell line Jurkat.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-040
.
General Information
p51 is a member of the p53 tumor suppressor gene family, which is induced by DNA damage and/or stress stimuli, causing cells to undergo G1-arrest or apoptotic death. Unlike ubiquitous expression of p53, expression of p51 is restricted to a limited number of tissues. The p51 gene encodes two major splicing variants, p51A (448 aa protein with a molecular weight of 50.9kDa) and p51B (641 aa protein with a molecular weight of 71.9kDa), a human homolog of rat Ket. p51A and p51B differ in their carboxyl-terminal structure.
BACKGROUND/TECHNICAL INFORMATION
Most of the p51A protein in Jurkat and K562 tumor cell lines is degraded.
General Literature References
Cloning and functional analysis of human p51, which structurally and functionally resembles p53:
M. Osada, et al.; Nature Med.
4
, 839 (1998)
Abstract
Human p53-p51 (p53-related) fusion protein: a potent BAX transactivator:
S. Ikawa, et al.; Jpn. J. Cancer Res.
90
, 596 (1999)
Abstract
p53 family genes: structural comparison, expression and mutation:
S. Ikawa, et al.; Cell Death Differ.
6
, 1154 (1999)
Abstract
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression:
P. Ruiz-Lozano, et al.; Cell Growth Differ.
10
, 295 (1999)
Abstract
;
Full Text
Failure of viral oncoproteins to target the p53-homologue p51A:
J. Roth & M. Dobbelstein; J. Gen. Virol.
80
, 3251 (1999)
Abstract
;
Full Text
Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer
:
M. Sunahara, et al.; Oncogene
18
, 3761 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-769
Revised 11-Apr-06
Polyclonal Antibody to p51B
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
p53 Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-769-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 623-641(N
623
FDMDARRNKQQRIKEEGE
641
) of C-terminal human p51B.
SPECIFICITY:
Recognizes human and mouse p51B. Detects a band of ~75kDA by Western blot. Does not cross-react with p51A.
APPLICATION:
Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1'000)
QUALITY CONTROL:
Western blot on mouse lung and human K562 cell line. As expected, some of the p51B is degraded in the tumor cell line K562.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-165-041
.
General Information
p51 is a member of the p53 tumor suppressor gene family, which is induced by DNA damage and/or stress stimuli, causing cells to undergo G1-arrest or apoptotic death. Unlike ubiquitous expression of p53, expression of p51 is restricted to a limited number of tissues. The p51 gene encodes two major splicing variants, p51A (448 aa protein with a molecular weight of 50.9kDa) and p51B (641 aa protein with a molecular weight of 71.9kDa), a human homolog of rat Ket. p51A and p51B differ in their carboxyl-terminal structure.
General Literature References
Cloning and functional analysis of human p51, which structurally and functionally resembles p53 :
M. Osada, et al.; Nat. Med.
4
, 839 (1998)
Abstract
Human p53-p51 (p53-related) fusion protein: a potent BAX transactivator :
S. Ikawa, et al.; Jpn. J. Cancer Res.
90
, 596 (1999)
Abstract
p53 family genes: structural comparison, expression and mutation :
S. Ikawa, et al.; Cell Death Differ.
6
, 1154 (1999)
Abstract
Failure of viral oncoproteins to target the p53-homologue p51A:
J. Roth & M. Dobbelstein; J. Gen. Virol.
80
, 3251 (1999)
Abstract
;
Full Text
p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression :
P. Ruiz-Lozano, et al.; Cell Growth Differ.
10
, 295 (1999)
Abstract
;
Full Text
Mutational analysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer
:
M. Sunahara, et al.; Oncogene
18
, 3761 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-833
Revised 07-Nov-07
Polyclonal Antibody to MMP-13 (human)
SYNONYMS
anti-Matrix Metalloproteinase 13 (human) PAb
anti-Collagenase-3 (human) PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-833-R100
100 µl
520.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In PBS, pH 7.5, containing 0.01% thimerosal.
IMMUNOGEN:
Recombinant human MMP-13 (matrix metalloproteinase 13).
SPECIFICITY:
Recognizes human MMP-13. Does not cross-react with human MMP-2, MMP-9, MMP-14, MMP-15, MMP-16 or MMP-17.
APPLICATION:
ELISA (detection; 1:2’000-1:4’000)
Western Blot (ECL-detection; 1:2’500 - 1:8’000)
Note:
For capture antibody use MAb to MMP-13 (Prod. No.
ALX-804-365
).
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-834
Revised 04-Dec-04
Polyclonal Antibody to MMP-14 (human)
SYNONYMS
anti-Matrix Metalloproteinase 14 (human) PAb
anti-Membrane-type 1 Matrix Metalloproteinase (human) PAb
anti-MT1-MMP (human) PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-834-R100
100 µl
520.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Purified. Contains 0.01% thimerosal.
IMMUNOGEN:
Synthetic peptide derived from hinge region between catalytic domain and hemopexin domain of MMP-14 (matrix metalloproteinase 14).
SPECIFICITY:
Recognizes human MMP-14. Does not cross-react with human MMP-15.
APPLICATION:
ELISA
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-841
Revised 13-Jun-08
Polyclonal Antibody to MRP1 (A23)
SYNONYMS
anti-Multidrug Resistance-associated Protein 1 PAb (A23)
anti-ABCC1 PAb (A23)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-841-C100
100 µg
280.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.5mg/ml.
PURITY:
>95% (SDS-PAGE).
PURITY DETAIL:
Affinity purified
FORMULATION:
Liquid. In PBS, containing 1% BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1509-1531 (G
1509
APSDLLQQRGLFYSMAKDAGLV
1531
) of C-terminal human MRP1 (multidrug resistance-associated protein 1).
SPECIFICITY:
Recognizes human, mouse and rat MRP1. May cross-react with rat MRP2 (cMOAT). Does not cross-react with human or mouse MRP2 (cMOAT).
APPLICATION:
Immunohistochemistry (frozen sections; 1:50-1:200)
Western Blot (1:300-1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Preparation of an antibody recognizing both human and rodent MRP1:
C. Fernetti, et al.; BBRC
288
, 1064 (2001)
Abstract
General Literature References
Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
:
E.M. Leslie, et al.; Toxicology
167
, 3 (2001)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-856
Revised 13-Jul-06
Polyclonal Antibody to MRP4 (human)
SYNONYMS
anti-Multidrug Resistance-associated Protein 4 (human) PAb
anti-ABCC4 (human) PAb
PRODUCT LINE
Cancer
PRODUCT CATEGORY
MDR-associated Proteins [MRPs] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-856-R200
200 µl
420.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1.5-2.0mg/ml
PURITY DETAIL:
Affinity purified.
FORMULATION:
Liquid. In borate buffer containing 0.1% BSA.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1249-1268 (S
1249
GRLKEYDEPYVLLQNKESL
1268
) of human MRP4 (multidrug resistance-associated protein 4).
SPECIFICITY:
Recognizes human MRP4. Does not cross-react with MRP4 of other species.
APPLICATION:
Western Blot (1:1’000)
Optimal conditions must be determined individually.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs
:
J.D. Schuetz, et al.; Nat. Med.
5
, 1048 (1999)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-876
Revised 26-Jun-08
Polyclonal Antibody to MMP-1
SYNONYMS
anti-Matrix Metalloproteinase 1 PAb
anti-Collagenase-1 PAb
anti-Interstitial Collagenase PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-876-C100
100 µg
303.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From guinea pig.
CONCENTRATION:
0.5mg/ml
FORMULATION:
Liquid. In PBS. Contains no preservatives.
IMMUNOGEN:
Matrix metalloproteinase 1 (MMP-1) from rabbit synovial fibroblasts.
SPECIFICITY:
Recognizes human, rabbit and marmoset MMP-1. Moderately cross-reacts with human MMP-3.
APPLICATION:
ELISA
Flow Cytometry
Immunocytochemistry
Immunohistochemistry
Immunoprecipitation
Western Blot (400-800ng/ml).
Optimal conditions should be determined individually.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Product Specific Literature References
Localization of matrix metalloproteinase 9 (92-kilodalton gelatinase/type IV collagenase = gelatinase B) in osteoclasts: implications for bone resorption
:
Y. Okada, et al.; Lab. Invest.
72
, 311 (1995)
Abstract
Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium
:
O. Lindy, et al.; Arthritis Rheum.
40
, 1391 (1997)
Abstract
The activity of collagenase-1 is required for keratinocyte migration on a type I collagen matrix:
B.K. Pilcher, et al.; J. Cell Biol.
137
, 1445 (1997)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-877
Revised 21-Dec-06
Polyclonal Antibody to MMP-3
SYNONYMS
anti-Matrix Metalloproteinase 3 PAb
anti-Procollagenase PAb
anti-Proteoglycanase PAb
anti-Stromelysin-1 PAb
anti-Transin-1 PAb
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Antibodies
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-877-C100
100 µg
363.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Others
SOURCE/HOST:
From guinea pig.
FORMULATION:
Liquid. Purified IgG fraction in PBS. Contains no preservatives.
IMMUNOGEN:
MMP-3 (matrix metalloproteinase 3) from rabbit synovial fibroblasts.
SPECIFICITY:
Recognizes human, rabbit and marmoset MMP-3. Does not cross-react with MMP-1, MMP-2, MMP-8 or MMP-9.
APPLICATION:
Immunoprecipitation (10-30µg/ml)
Western Blot (400-900ng/ml).
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
-20°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-894
Revised 12-Sep-05
Polyclonal Antibody to Tenascin-W
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
Cytoskeleton & Extracellular Matrix Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-894-C100
100 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY:
≥90%
PURITY DETAIL:
Protein A-affinity purified.
FORMULATION:
Liquid. In TRIS/glycine, pH 8.0, containing 0.01% sodium azide.
IMMUNOGEN:
Recombinant FNIII repeats 7-9 of mouse tenascin-W.
SPECIFICITY:
Recognizes human, mouse and rat tenascin-W.
APPLICATION:
ELISA (1:10’000)
Immunocytochemistry (1:1’000)
Immunohistochemistry (frozen sections, paraffin sections (1:500))
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development:
A. Scherberich, et al.; J. Cell Sci.
117
, 571 (2004)
Abstract
;
Full Text
Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro:
A. Scherberich, et al.; Oncogene
24
, 1525 (2005)
Abstract
General Literature References
Tenascins:
R. Chiquet-Ehrismann; Int. J. Biochem. Cell Biol.
36
, 986 (2004)
Abstract
Connective tissues: signalling by tenascins:
R. Chiquet-Ehrismann and R.P. Tucker; Int. J. Biochem. Cell Biol.
36
, 1085 (2004)
Abstract
Further Categories Containing This Product:
Polyclonal Antibodies
Tumor Markers
ALX-210-910
Revised 29-Feb-08
Polyclonal Antibody to CYLD (human) (AF888)
SYNONYMS
anti-Cylindromatosis Tumor Suppressor Protein (human) PAb (AF888)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
NF-kB Pathway Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-910-C050
50 µg
195.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
0.45mg/ml
PURITY DETAIL:
Epitope-affinity purified.
