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Chemopreventive Agents & Inhibitors of Carcinogenesis
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ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Lipopolysaccharides [LPS]/Related Products • Glutathione S-Transferase • Natural Products - Apoptosis Inducers & Inhibitors • Cytochrome P450 [CYP450]/Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-350-222 Revised 28-Mar-08
Dihydromyristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-222-M100   100 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C11H14O3
MW: 194.2
CAS NUMBER: 52811-28-6
PURITY: ≥98% (TLC)
APPEARANCE: Colorless liquid.
SOLUBILITY: Soluble in 100% ethanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Hydrogenated product of myristicin (Prod. No. ALX-350-227), a natural constituent of parsley. Inducer of glutathione S-transferases.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Further Categories Containing This Product:
Glutathione S-Transferase • Antitumor Agents (Enzyme Activators & Inducers) • Active Substances from Fruit and Vegetables
 
 
ALX-270-102 Revised 10-Aug-07
Naproxen
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SYNONYMS (S)-6-Methoxy-α-methyl-2-naphthalene acetic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-102-G005   5 g 35.00 USD Add To Cart
Product Specification
FORMULA: C14H14O3
MW: 230.3
CAS NUMBER: 22204-53-1
MERCK INDEX: 14: 6417
PURITY: ≥98% (Assay)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide and 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL. MAY BE TERATOGENIC.

Product Description
Cyclooxygenase (COX) inhibitor. Widely used non-steroidal anti-inflammatory drug.
Product Specific Literature References
Perspectives in nonsteroidal anti-inflammatory agents: T.Y. Shen; Angew. Chem. Int. Ed. 11, 460 (1972) Abstract
Further Categories Containing This Product:
COX Inhibitors • PPAR Agonists
 
 
ALX-270-196 Revised 12-Sep-05
Niflumic acid
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SYNONYMS Nifluril
2-[[3-(Trifluoromethyl)phenyl]-amino]-3-pyridinecarboxylic acid
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-196-G005   5 g 26.00 USD Add To Cart
Product Specification
FORMULA: C13H9F3N2O2
MW: 282.2
CAS NUMBER: 4394-00-7
MERCK INDEX: 14: 6531
PURITY: ≥99%
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Stable for at least 1 year when stored at room temperature. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. We do not recommend storing the aqueous solution for more than one day.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2).
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-270-193 Revised 04-Mar-05
Nimesulide
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SYNONYMS N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-193-G005   5 g 80.00 USD Add To Cart
Product Specification
FORMULA: C13H12N2O5S
MW: 308.3
CAS NUMBER: 51803-78-2
MERCK INDEX: 14: 6548
PURITY: ≥99%
APPEARANCE: Light tan crystals.
SOLUBILITY: Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.
Product Specific Literature References
Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2): R. Huff, et al.; Inflamm. Res. 44, S145 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers) • COX Inhibitors
 
 
ALX-350-228 Revised 08-Jul-08
Nomilin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-228-M025   25 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C28H34O9
MW: 514.6
CAS NUMBER: 1063-77-0
MERCK INDEX: 14: 6674
SOURCE/HOST: Isolated from grapefruit seed and citrus juice.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone; slightly soluble in 100% ethanol, methanol, isopropanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Induces phase II detoxifying enzymes and inhibits chemically induced carcinogenesis. Exhibits immunomodulatory activity and also inhibits HIV-1 replication. Does not possess any inherent antioxidant capacity.
Product Specific Literature References
V.P. Maier, et al.; ACS Symposium Series 143, 63 (1980)
Inhibition of benzo[a]pyrene-induced forestomach neoplasia in mice by citrus limonoids: L.K.T. Lam & S. Hasegawa; Nutr. Cancer 12, 43 (1989) Abstract
The effect of citrus limonoids on hamster buccal pouch carcinogenesis: E.G. Miller, et al.; Carcinogenesis 10, 1535 (1989) Abstract
Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system: T.J. Raphael & G. Kuttan; Phytomedicine 10, 483 (2003) Abstract
Effect of limonin and nomilin on HIV-1 replication on infected human mononuclear cells: L. Battinelli, et al.; Planta Med. 69, 910 (2003) Abstract
Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside: A.P. Breksa, 3rd & G.D. Manners; J. Agric. Food Chem. 54, 3827 (2006) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Antiviral/anti-HIV Agents • Natural Products - Immunomodulators • Active Substances from Fruit and Vegetables
 
 
ALX-270-197 Revised 15-Jan-08
NS-398
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SYNONYMS N-[2-(Cyclohexyloxy)-4-nitrophenyl]-methanesulfonamide
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-270-197-M005   5 mg 55.00 USD Add To Cart
ALX-270-197-M010   10 mg 98.00 USD Add To Cart
ALX-270-197-M050   50 mg 395.00 USD Add To Cart
Product Specification
FORMULA: C13H18N2O5S
MW: 314.4
CAS NUMBER: 123653-11-2
PURITY: ≥98% (1H-NMR)
APPEARANCE: White to off-white crystalline solid
SOLUBILITY: Soluble in 100% ethanol (warm; sonification), DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Potent and selective cyclooxygenase-2 (COX-2) inhibitor.
Product Specific Literature References
Effect of NS-398, a new nonsteroidal anti-inflammatory agent, on gastric ulceration and acid secretion in rats: I. Arai, et al.; Res. Comm. Chem. Pathol. Pharmacol. 81, 259 (1993) Abstract
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions: N. Futaki, et al.; Gen. Pharmacol. 24, 105 (1993) Abstract
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro: N. Futaki, et al.; Prostaglandins 47, 55 (1994) Abstract
Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic: J.L. Masferrer, et al.; PNAS 91, 3228 (1994) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract
Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms: M. Ouellet & M.D. Percival; Biochem. J. 306, 247 (1995) Abstract
Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism: M.C. Zatelli, et al.; J. Clin. Endocrinol. Metab. 90, 5754 (2005) Abstract; Full Text
Further Categories Containing This Product:
COX Inhibitors
 
 
ALX-350-304 Revised 04-Jan-08
Odorine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-304-MC05   0.5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C18H24N2O2
MW: 300.4
CAS NUMBER: 72755-20-5
SOURCE/HOST: Isolated from Aglaia odorata.
PURITY: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Cancer chemopreventive agent. Inhibits both the initiation and promotion stages of two-stage skin carcinogenesis.
Product Specific Literature References
Diamide derivatives and cycloartanes from the leaves of Aglaia elliptica: A. Inada, et al.; Chem. Pharm. Bull. (Tokyo) 49, 1226 (2001) Abstract
Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata: A. Inada, et al.; Biol. Pharm. Bull. 24, 1282 (2001) Abstract; Full Text
 
 
ALX-350-306 Revised 31-May-07
Odorinol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-306-MC05   0.5 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C18H24N2O3
MW: 316.4
CAS NUMBER: 72755-22-7
SOURCE/HOST: Isolated from Aglaia odorata.
PURITY: ≥97% (HPLC)
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Cancer chemopreventive agent. Inhibits both the initiation and promotion stages of two-stage skin carcinogenesis.
Product Specific Literature References
Cancer chemopreventive activity of odorine and odorinol from Aglaia odorata: A. Inada, et al.; Biol. Pharm. Bull. 24, 1282 (2001) Abstract; Full Text
 
 
ALX-385-015 Revised 12-Aug-08
Peonidin chloride
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SYNONYMS 3,4',5,7-Tetrahydroxy-3'-methoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-015-M005   5 mg 280.00 USD Add To Cart
Product Specification
FORMULA: C16H13O6Cl
MW: 336.7
CAS NUMBER: 134-01-0
MERCK INDEX: 14: 7143
PURITY: ≥99% (HPLC)
APPEARANCE: Beige to reddish-brown solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Antioxidant flavonoid. Shows anti-inflammatory and chemopreventive properties.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Peonidin inhibits phorbol-ester-induced COX-2 expression and transformation in JB6 P+ cells by blocking phosphorylation of ERK-1 and -2: J.Y. Kwon, et al.; Ann. N. Y. Acad. Sci. 1095, 513 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants
 
 
ALX-430-112 Revised 20-Aug-03
Phenylbutazone
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SYNONYMS 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione
PRODUCT LINE Inflammation
PRODUCT CATEGORY Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]
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ALX-430-112-G005   5 g 10.00 USD Add To Cart
Product Specification