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Antitumor Antibiotics
You are here: Product Lines > Natural Products / Antibiotics > Antibiotics > Antibiotics for Cancer Research > Antitumor Antibiotics
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ALX-804-624 Revised 20-Jun-05
Monoclonal Antibody to Doxorubicin (MAD11)
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SYNONYMS anti-DXR MAb (MAD11)
anti-14-Hydroxydaunomycin MAb (MAD11)
anti-Adriamycin MAb (MAD11)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-624-C100   100 µg 320.00 USD Add To Cart
Product Specification
CLONE: MAD11
ISOTYPE: Mouse IgG2
CONCENTRATION:   
FORMULATION: Liquid. Purified antibody containing 150mM sodium chloride and 0.02% sodium azide, pH 7.4.
IMMUNOGEN: Doxorubicin-BSA.
SPECIFICITY: Recognizes anthracycline compounds including doxorubicin analogs and derivatives.
APPLICATION: ELISA
Immunohistochemistry
Functional Application: In vivo antidotic effect.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
Product Specific Literature References
Monoclonal antibodies against doxorubicin: A. Balsari, et al.; Int. J. Cancer 42, 798 (1988) Abstract
A new monoclonal antibody recognizing anthracyclinic molecule: A. Balsari, et al.; Anticancer Res. 10, 129 (1990) Abstract
Anti-drug monoclonal antibodies antagonize toxic effect more than anti-tumor activity of doxorubicin: A. Balsari, et al.; Int. J. Cancer 47, 889 (1991) Abstract
An anti-doxorubicin monoclonal antibody modulates kinetic and dynamic characteristics of the drug: A. Sardini, et al.; Int. J. Cancer 50, 617 (1992) Abstract
Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies: A.L. Balsari, et al.; FASEB J. 8, 226 (1994) Abstract
Effect of a bifunctional monoclonal antibody directed against a tumor marker and doxorubicin on the growth of epidermoid vulvar carcinoma grafted in athymic mice: D. Morelli, et al.; Cell Biophys. 24-25, 119 (1994) Abstract
Relevance of antibody valency in EGF receptor modulation: D. Morelli, et al.; Scand. J. Immunol. 39, 453 (1994) Abstract
Oral administration of anti-doxorubicin monoclonal antibody prevents chemotherapy-induced gastrointestinal toxicity in mice: D. Morelli, et al.; Cancer Res. 56, 2082 (1996) Abstract
Apoptosis of hair follicle cells during doxorubicin-induced alopecia in rats: R. Cece, et al.; Lab. Invest. 75, 601 (1996) Abstract
Intratibial injection of an anti-doxorubicin monoclonal antibody prevents drug-induced myelotoxicity in mice: D. Morelli, et al.; Br. J. Cancer 75, 656 (1997) Abstract
Topical administration of a doxorubicin-specific monoclonal antibody prevents drug-induced mouth apoptosis in mice: A. Balsari, et al.; Br. J. Cancer 85, 1964 (2001) Abstract
Role of proliferation in HER2 status predicted response to doxorubicin: M. Campiglio, et al.; Int. J. Cancer 105, 568 (2003) Abstract
Further Categories Containing This Product:
Cancer Other Products • Topoisomerases Other Products • Antibiotics - Topoisomerase Inhibitors • Monoclonal Antibodies
 
 
ALX-380-233 Revised 08-Apr-08
Neoantimycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-233-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C36H46N2O12
MW: 698.8
CAS NUMBER: 22862-63-1
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS4461.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Antibiotic. Displays potent nematocidal and antitumor activity.
Product Specific Literature References
The structure of neoantimycin: L. Caglioti, et al.; Tetrahedron 25, 2193 (1969) Abstract
 
 
ALX-380-088 Revised 30-Jul-08
Netropsin . dihydrochloride
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SYNONYMS 4-([((Aminoiminomethyl)amino)acetyl)amino)-N-(5-(((3-amino-3-iminopropyl)amino)carbonyl]-1-methyl-1H-pyrrol-3-yl)-1-methyl-1H-pyrrole-3-carboxamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-088-M005   5 mg 40.00 USD Add To Cart
Product Specification
FORMULA: C18H26N10O3 . 2HCl
MW: 430.5 . 73.0
CAS NUMBER: 63770-20-7 (hydrochloride)
RTECS: DW2973000
SOURCE/HOST: Isolated from Streptomyces netropsis.
PURITY: ≥93% (HPLC)
APPEARANCE: Faint yellow powder.
SOLUBILITY: Soluble in alcohols or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Nucleic acid binding ligand. Binds to A-T-rich regions of the minor groove of DNA.
Product Specific Literature References
Netropsin, a New Antibiotic Produced by a Streptomyces: A.C. Finlay et al.; J. Am. Chem. Soc. 73, 341 (1951)
Efficient Total Syntheses of the Oligopeptide Antibiotics Netropsin and Distamycin: J.W. Lown et al.; J. Org. Chem. 50, 3774 (1985)
Sequence and structural selectivity of nucleic acid binding ligands: J. Ren & J.B. Chaires; Biochemistry 38, 16067 (1999) Abstract
Molecular modelling of the interaction of carbocyclic analogues of netropsin and distamycin with d(CGCGAATTCGCG)2: K. Bielawski, et al.; Acta Biochim. Pol. 47, 855 (2000) Abstract
Recent developments in sequence selective minor groove DNA effectors: B.S. Reddy, et al.; Curr. Med. Chem. 8, 475 (2001), (Review) Abstract
Further Categories Containing This Product:
Other Antibiotics - DNA Regulation/Transcription • Antibiotics - Antiviral/Anti-HIV
 
 
ALX-380-037 Revised 20-Jun-08
Oligomycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-037-M005   5 mg 50.00 USD Add To Cart
ALX-380-037-M010   10 mg 95.00 USD Add To Cart
Product Specification
MW: 789.3
CAS NUMBER: 1404-19-9
MERCK INDEX: 14: 6833
RTECS: RK3325000
SOURCE/HOST: Isolated from Streptomyces diastatochromogens.
PURITY: ≥90% (mixture of oligomycin A, B, and C (~65% oligomycin A))
APPEARANCE: White to faint yellow powder.
SOLUBILITY: Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. MAY BE MUTAGENIC.

Product Description
Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993) Abstract
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993) Abstract
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993) Abstract
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994) Abstract
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998) Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000) Abstract
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-036 Revised 10-Dec-07
Oligomycin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-036-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C45H74O11
MW: 791.1
CAS NUMBER: 579-13-5
MERCK INDEX: 14: 6833
RTECS: RK3328000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Major component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis. Induces autophagy in the IPLB-LdFB insect cell line.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2000) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res. 326, 179 (2006) Abstract
Further Categories Containing This Product:
Antibiotics - ATPase Inhibitors • H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - Antifungal
 
 
ALX-380-038 Revised 10-Dec-07
Oligomycin B
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SYNONYMS 28-Oxooligomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-038-M005   5 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C45H72O12
MW: 805.1
CAS NUMBER: 11050-94-5
MERCK INDEX: 14: 6833
RTECS: RK3330000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL. MAY BE MUTAGENIC.

Product Description
Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Egr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2000) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-039 Revised 10-Dec-07
Oligomycin C
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SYNONYMS 12-Deoxyoligomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-039-M001   1 mg 330.00 USD Add To Cart
Product Specification
FORMULA: C45H74O10
MW: 775.1
CAS NUMBER: 11052-72-5
MERCK INDEX: 14: 6833
RTECS: RK3335000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5339.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Minor component of the oligomycin complex. Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F1F0), preventing phosphoryl group transfer. Induces apoptosis.
Product Specific Literature References
Production and isolation of the antibiotic, oligomycin: J. Visser, et al.; J. Biochem. Microbiol. Technol. Engr. 2, 31 (1960) Abstract
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ. 7, 338 (2000) Abstract; Full Text
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene 21, 8149 (2002) Abstract; Full Text
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy 50, 55 (2004) Abstract
Further Categories Containing This Product:
H+-ATPase/Related Products • Antitumor Antibiotics • Respiratory Chain Other Products • Antibiotics - ATPase Inhibitors • Antibiotics - Antifungal
 
 
ALX-380-235 Revised 20-Jun-08
Piericidin A
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SYNONYMS Piericidin A1
Shaoguanmycin B
Antibiotic MT 1882-I
Antibiotic SN 198E
Antibiotic IT 143D
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-235-M002   2 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C25H37NO4
MW: 415.6
CAS NUMBER: 2738-64-9
RTECS: YD4588000
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5364.
PURITY: ≥95% (HPLC)
APPEARANCE: Pale yellow oil.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC.

Product Description
Antibiotic. Specific and potent inhibitor of NADH-ubiquinone oxidoreductase (complex I) that binds to ubiquinone binding site(s). Inhibits both mitochondrial and bacterial NADH ubiquinone oxidoreductase. Anticancer agent that prevents up-regulation of GRP78, and exhibits cytotoxic activity for etoposide resistant cancer cells under glucose-deprived conditions.
Product Specific Literature References
Piericidin A: a new inhibitor of mitochondrial electron transport: C. Hall, et al.; BBRC 25, 373 (1966) Abstract
Two binding sites of inhibitors in NADH: ubiquinone oxidoreductase (complex I). Relationship of one site with the ubiquinone-binding site of bacterial glucose:ubiquinone oxidoreductase: T. Friedrich, et al.; Eur. J. Biochem. 219, 691 (1994) Abstract
The 49-kDa subunit of NADH-ubiquinone oxidoreductase (Complex I) is involved in the binding of piericidin and rotenone, two quinone-related inhibitors: E. Darrouzet, et al.; FEBS Lett. 431, 34 (1998) Abstract; Full Text
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I: I. Prieur, et al.; Biochim. Biophys. Acta 1504, 173 (2001) Abstract
Etoposide-resistant HT-29 human colon carcinoma cells during glucose deprivation are sensitive to piericidin A, a GRP78 down-regulator: J.H. Hwang, et al.; J. Cell. Physiol. 215, 243 (2008) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
ALX-380-127 Revised 30-Jun-08 New product
Polyketomycin
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SYNONYMS Antibiotic K99-5147
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-127-M001   1 mg 100.00 USD Add To Cart
Product Specification
FORMULA: C44H48O18
MW: 864.9
CAS NUMBER: 200625-47-4
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Orange to dark brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Tetracyclic quinone glycoside. Displays antibacterial, antimalarial and antitumor activity.
Product Specific Literature References
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities: I. Momose, et al.; J. Antibiot. 51, 21 (1998) Abstract
Polyketomycin, a new antibiotic from Streptomyces sp. MK277-AF1. II. Structure determination: I. Momose, et al.; J. Antibiot. 51, 26 (1998) Abstract
Biosynthesis of polyketomycin produced by Streptomyces diastatochromogenes Tü 6028: T. Paululat, et al.; J. Antibiot. 52, 96 (1999) Abstract
In vitro antimalarial activities of the microbial metabolites: K. Otoguro, et al.; J. Antibiot. 56, 322 (2003) Abstract
Synthesis of the polyketomycin disaccharide: D.S. Micalizzi, et al.; Tetrahedron: Asymmetry 14, 3183 (2003)
Further Categories Containing This Product:
Antibiotics - Antimalarial • Antitumor Antibiotics
 
 
ALX-480-083 Revised 05-Jun-07
Puromycin aminonucleoside
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SYNONYMS 3'-Amino-3'-deoxy-N,N-dimethyl-adenosine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-480-083-M010   10 mg 50.00 USD Add To Cart
ALX-480-083-M050