ALEXIS Biochemicals: Angiopoietin-2 (human) (recombinant)

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ALX-270-434

Revised 18-Apr-06

Tie-2 Inhibitor 13
SYNONYMS	(1Z)-5-Fluoro-2-methyl-1-(3-thienylmethylene)-1H-indene-3-acetic acid
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Angiopoietins & Tie Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-434-M001		1 mg	110.00 USD

Product Specification

FORMULA:	C₁₇H₁₃FO₂S
MW:	300.6
CAS NUMBER:	857250-95-4
PURITY:	≥95%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months when stored at -20°C in the dark.
HANDLING:	Protect from light.
IDENTITY:	Identity determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Potent and cell permeable Tie-2 inhibitor (IC₅₀=600nm).

Product Specific Literature References

Inhibition of angiogenesis-relevant receptor tyrosine kinases by sulindac analogues: E. Gourzoulidou, et al.; Chembiochem. 6, 527 (2005) Abstract
Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity: J. Hoffmann, et al.; FASEB J. 19, 2035 (2005) Abstract

ALX-201-313

Revised 18-Mar-08

Angiopoietin-1 (human) (recombinant)
SYNONYMS	Ang-1 (human) (recombinant)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Angiopoietins & Tie Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-313-C010		10 µg	295.00 USD
ALX-201-313-C050		50 µg	795.00 USD

Product Specification

SOURCE/HOST:	Produced in CHO cells. Human Ang-1 (angiopoietin-1) (aa 20-498) is fused at the N-terminus to a FLAG^®-tag.
CONCENTRATION:	~0.2mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm-filtered solution in PBS containing 0.02% CHAPS.
ENDOTOXIN CONTENT:	<0.1EU/µg protein (LAL test; Bio Whittaker)
BIOLOGICAL ACTIVITY:	Induces the phosphorylation of Tie-2 in primary cultured human vascular endothelial cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 6 months when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Images

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General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15389: Angiopoietin-1 (human)

FLAG is a registered trademark of Sigma-Aldrich Co.

MANUFACTURER

Manufactured by AdipoGen, Inc.

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

ALX-201-314

Revised 18-Mar-08

COMP (rat):Angiopoietin-1 (human) (recombinant)
SYNONYMS	COMP (rat):Ang-1 (human) (recombinant)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Angiopoietins & Tie Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-314-C010		10 µg	360.00 USD
ALX-201-314-C050		50 µg	980.00 USD
ALX-201-314-C500		500 µg	3'200.00 USD
ALX-201-314-M001		1 mg	5'800.00 USD

Product Specification

SOURCE/HOST:	Produced in CHO cells. The fibrinogen-like domain (aa 284-498) of human Ang-1 (angiopoietin-1) is fused at the N-terminus to the coiled-coil domain of rat COMP (cartilage oligomeric matrix protein) and to a FLAG^®-tag.
CONCENTRATION:	0.3mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm-filtered solution in PBS containing 0.01% CHAPS.
ENDOTOXIN CONTENT:	<0.1EU/µg protein (LAL test; BioWhittaker)
SPECIFICITY:	Binds to human Tie-2.
BIOLOGICAL ACTIVITY:	Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.

Product Images

Please click on thumbnails to enlarge.

Product Description

Soluble, stable and more potent Ang-1 variant.

Product Specific Literature References

COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity: C.H. Cho, et al.; PNAS 101, 5547 (2004) Abstract; Full Text
Designed angiopoietin-1 variant, COMP-Ang1, protects against radiation-induced endothelial cell apoptosis: C.H. Cho, et al.; PNAS 101, 5553 (2004) Abstract; Full Text
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2: P. Saharinen, et al.; J. Cell Biol. 169, 239 (2005) Abstract
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation: T. Morisada, et al.; Blood 105, 4649 (2005) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q15389: Angiopoietin-1 (human)
Swiss-Prot link P35444: COMP (rat)

FLAG is a registered trademark of Sigma-Aldrich Co.

Please also see our Product Flyer "COMP:Angiopoietin-1, More Stable, Active and Potent".

MANUFACTURER

Manufactured by AdipoGen, Inc.

Further Categories Containing This Product:

Recombinant Proteins / Fusion Proteins

ALX-201-315

Revised 18-Mar-08

Angiopoietin-2 (human) (recombinant)
SYNONYMS	Ang-2 (human) (recombinant)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Angiopoietins & Tie Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-201-315-C010		10 µg	295.00 USD
ALX-201-315-C050		50 µg	795.00 USD

Product Specification

SOURCE/HOST:	Produced in CHO cells. Human Ang-2 (angiopoietin-2) (aa 19-496) is fused at the N-terminus to a FLAG^®-tag.
CONCENTRATION:	0.2mg/ml
PURITY:	≥90% (SDS-PAGE)
FORMULATION:	Liquid. 0.2µm filtered solution in PBS containing 0.02% CHAPS.
ENDOTOXIN CONTENT:	<0.1EU/µg protein (LAL test; Bio Whittaker)
BIOLOGICAL ACTIVITY:	Induces the phosphorylation of Tie-2 in primary cultured human vascular endothelial cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Working aliquots are stable for up to 6 months when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.