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ALX-105-011
Revised 18-Sep-06
S-Trityl-L-cysteine
SYNONYMS
NSC 83265
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
Cell Cycle Blockers & Inhibitors / Related Products
Ordering Information
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ALX-105-011-M100
100 mg
20.00 USD
ALX-105-011-M500
500 mg
60.00 USD
Product Specification
FORMULA:
C
22
H
21
NO
2
S
MW:
363.5
CAS NUMBER:
2799-07-7
RTECS:
AY7710000
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO or acetic acid
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Potent, cell permeable cysteine thioether displaying anti-mitotic and anti-tumor properties. Inhibits mitosis by blocking basal and microtubule-activated ATPase activities of the mitotic kinesin Eg5 (IC
50
=1µM and 140nm). Induces mitotic arrest in HeLa cells (IC
50
=700nM) and inhibits the growth of NCI tumor cell line panel (GI
50
=1.31µM).
Product Specific Literature References
In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities:
S. DeBonis, et al.; Mol. Cancer Ther.
3
, 1079 (2004)
Abstract
;
Full Text
S-trityl-l-cysteine is a reversible, tight-binding inhibitor of the human kinesin eg5 that specifically blocks mitotic progression:
D.A. Skoufias, et al.; J. Biol. Chem.
281
, 17559 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
Kinesin & Kinesin-like Proteins / Related Products
•
Antitumor Agents (Anti-proliferative)
ALX-151-024
Revised 03-Mar-05
H-Ala-Pro-Arg-Thr-Pro-Gly-Gly-Arg-Arg-OH
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-151-024-M001
1 mg
95.00 USD
ALX-151-024-M005
5 mg
380.00 USD
Product Specification
FORMULA:
C
39
H
70
N
18
O
11
MW:
967.1
PURITY:
≥98%
APPEARANCE:
White powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for myelin basic protein kinase (p44
mpk
) and for MAP kinase (MAPK/ERK).
Product Specific Literature References
Identification of the sites in myelin basic protein that are phosphorylated by meiosis-activated protein kinase p44mpk:
J.S. Sanghera, et al.; FEBS Lett.
273
, 223 (1990)
Abstract
Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase:
I. Clark-Lewis, et al.; J. Biol. Chem.
266
, 15180 (1991)
Abstract
;
Full Text
M. Daeipour, et al.; J. Immunol.
150
, 4743 (1993)
Abstract
Further Categories Containing This Product:
Peptides
ALX-162-009
Revised 04-Jul-07
Myelin Basic Protein (4-14) (bovine)
SYNONYMS
MBP (4-14) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-162-009-M001
1 mg
85.00 USD
ALX-162-009-M005
5 mg
330.00 USD
Product Specification
SEQUENCE:
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA:
C
60
H
103
N
21
O
17
MW:
1390.6
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Specific and convenient substrate for protein kinase C (PKC). Very poor substrate for phosphorylase kinase, CaM kinase II, casein kinases I and II and cAMP-dependent protein kinase (PKA).
Product Specific Literature References
A phosphatase resistant substrate for the assay of protein kinase C in crude tissue extracts:
Y.J.K. Farrar, et al.; BBRC
180
, 694 (1991)
Abstract
A synthetic peptide substrate for selective assay of protein kinase C:
I. Yasuda, et al.; BBRC
166
, 1220 (1990)
Abstract
Further Categories Containing This Product:
PKC Substrates
•
Peptides
ALX-162-010
Revised 28-Jul-08
Myelin Basic Protein (104-118) (bovine)
SYNONYMS
MBP (104-118) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
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ALX-162-010-M001
1 mg
95.00 USD
ALX-162-010-M005
5 mg
380.00 USD
Product Specification
SEQUENCE:
H-Gly-Lys-Gly-Arg-Gly-Leu-Ser-Leu-Ser-Arg-Phe-Ser-Trp-Gly-Ala-OH
FORMULA:
C
70
H
111
N
23
O
19
MW:
1578.8
PURITY:
≥97%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein kinase C (PKC).
Product Specific Literature References
Substrate specificity of phospholipid/Ca2+-dependent protein kinase as probed with synthetic peptide fragments of the bovine myelin basic protein:
R.S. Turner, et al.; J. Biol. Chem.
260
, 11503 (1985)
Abstract
;
Full Text
Synthetic myelin basic protein peptide analogs are specific inhibitors of phospholipid/calcium-dependent protein kinase (protein kinase C):
H. Su, et al.; BBRC
134
, 78 (1986)
Abstract
Further Categories Containing This Product:
PKC Substrates
•
Peptides
ALX-162-011
Revised 12-Aug-08
Myosin Light Chain Kinase (11-19) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Myosin Light Chain Kinase Substrates
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ALX-162-011-M001
1 mg
70.00 USD
ALX-162-011-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-NH
2
FORMULA:
C
40
H
78
N
18
O
11
MW:
987.2
PURITY:
≥95%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in distilled water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Effective inhibitor of the smooth muscle myosin light chain kinase.
Product Specific Literature References
Smooth muscle myosin kinase requires residues on the COOH-terminal side of the phosphorylation site. Peptide inhibitors:
R.B. Pearson, et al.; J. Biol. Chem.
261
, 25 (1986)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-162-012
Revised 09-Feb-05
Myosin Light Chain Kinase (342-352) amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Myosin Light Chain Kinase Substrates
Ordering Information
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ALX-162-012-M001
1 mg
70.00 USD
ALX-162-012-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Lys-Arg-Arg-Trp-Lys-Lys-Asn-Phe-Ile-Ala-Val-NH
2
FORMULA:
C
68
H
113
N
23
O
12
MW:
1444.9
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
The peptide corresponds to part of the calmodulin-binding sequence in skeletal muscle myosin light chain kinase.
Product Specific Literature References
The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence:
B.E. Kemp, et al.; J. Biol. Chem.
262
, 2542 (1987)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-162-013
Revised 09-Feb-05
Myosin Light Chain Kinase Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Myosin Light Chain Kinase Substrates
Ordering Information
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ALX-162-013-M001
1 mg
70.00 USD
ALX-162-013-M005
5 mg
280.00 USD
Product Specification
SEQUENCE:
H-Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala-NH
2
FORMULA:
C
61
H
107
N
23
O
16
MW:
1418.7
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for the smooth muscle myosin light chain kinase.
Product Specific Literature References
Spatial requirements for location of basic residues in peptide substrates for smooth muscle myosin light chain kinase:
B.E. Kemp & R.B. Pearson; J. Biol. Chem.
260
, 3355 (1985)
Abstract
;
Full Text
Further Categories Containing This Product:
Peptides
ALX-162-016
Revised 04-Jul-07
[Pyr4]-Myelin Basic Protein (4-14) (bovine)
SYNONYMS
[Pyr
4
]-MBP (4-14) (bovine)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
Ordering Information
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ALX-162-016-M001
1 mg
95.00 USD
ALX-162-016-M005
5 mg
380.00 USD
Product Specification
SEQUENCE:
Pyr-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
FORMULA:
C
60
H
100
N
20
O
17
MW:
1373.6
CAS NUMBER:
136132-68-8
PURITY:
≥96%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Very selective substrate for protein kinase C (PKC).
Product Specific Literature References
A synthetic peptide substrate for selective assay of protein kinase C:
I. Yasuda, et al.; BBRC
166
, 1220 (1990)
Abstract
Peptide fragments of myelin basic protein as substrates of protein kinase C:
M. Eller, et al.; Biochem. Int.
27
, 625 (1992)
Abstract
Further Categories Containing This Product:
Peptides
•
PKC Substrates
ALX-162-019
Revised 04-Jul-07
[Ala96]-Myelin Basic Protein (87-99) (human, bovine, rat)
SYNONYMS
[Ala
96
]-MBP (87-99) (human, bovine, rat)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
Ordering Information
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ALX-162-019-M001
1 mg
80.00 USD
ALX-162-019-M005
5 mg
320.00 USD
Product Specification
SEQUENCE:
H-Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Ala-Arg-Thr-Pro-OH
FORMULA:
C
72
H
112
N
20
O
17
MW:
1529.8
PURITY:
≥96%
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein:
S. Brocke, et al.; Nature
379
, 343 (1996)
Abstract
Further Categories Containing This Product:
Peptides
ALX-162-030
Revised 18-Jan-07
Myelin Oligodendrocyte Glycoprotein (35-55) (mouse, rat)
SYNONYMS
MOG (35-55) (mouse, rat)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
Ordering Information
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ALX-162-030-MC05
0.5 mg
90.00 USD
ALX-162-030-M001
1 mg
150.00 USD
Product Specification
SEQUENCE:
H-Met-Glu-Val-Gly-Trp-Tyr-Arg-Ser-Pro-Phe-Ser-Arg-Val-Val-His-Leu-Tyr-Arg-Asn-Gly-Lys-OH
FORMULA:
C
118
H
177
N
35
O
29
S
MW:
2582.0
PURITY:
≥85% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
<1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism:
S. Pluchino, et al.; Nature
436
, 266 (2005)
Abstract
Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy:
E. Zappia, et al.; Blood
106
, 1755 (2005)
Abstract
;
Full Text
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice:
G. van Loo, et al.; Nat. Immunol.
7
, 954 (2006)
Abstract
General Information
MANUFACTURER
Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases:
F. Lolli, et al.; Curr. Protein Pept. Sci.
4
, 277 (2003)
Abstract
Further Categories Containing This Product:
Peptides
ALX-162-031
Revised 14-Aug-06
Myelin Proteolipid Protein (139-151) (human, bovine, dog, mouse, rat)
SYNONYMS
PLP (139-151) (human, bovine, dog, mouse, rat)
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Myelin Basic Protein / Related Products
Ordering Information
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ALX-162-031-M001
1 mg
80.00 USD
Product Specification
SEQUENCE:
H-His-Cys-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH
FORMULA:
C
72
H
104
N
20
O
16
S
MW:
1537.8
PURITY:
≥85% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
<1mg/ml soluble in water, methanol, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Specific Literature References
Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism:
S. Pluchino, et al.; Nature
436
, 266 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by EspiKem, Srl.
General Literature References
Synthetic peptides in the diagnosis of neurological diseases:
F. Lolli, et al.; Curr. Protein Pept. Sci.
4
, 277 (2003)
Abstract
Further Categories Containing This Product:
Peptides
