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Cancer
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ALX-201-358 Revised 18-Mar-08
Clusterin (secretory form) (human) (recombinant)
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SYNONYMS TRPM-2 (secretory form) (human) (recombinant)
Apolipoprotein J (secretory form) (human) (recombinant)
APO-J (secretory form) (human) (recombinant)
CLI (secretory form) (human) (recombinant)
CLU (secretory form) (human) (recombinant)
SGP-2 (secretory form) (human) (recombinant)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-358-C010   10 µg 230.00 USD Add To Cart
ALX-201-358-C050   50 µg 480.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. The signal peptide sequence and the mature human secretory clusterin (aa 1-449) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2 µm-filtered solution in PBS, pH 7.2.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P10909: Clusterin (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-359 Revised 18-Mar-08
ANGPTL3 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 3 (human) (recombinant)
Angiopoietin-5 (human) (recombinant)
ANG-5 (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-359-C010   10 µg 295.00 USD Add To Cart
ALX-201-359-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human ANGPTL3 (angiopoietin-like protein 3) (aa 1-460) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5C1: Angiopoietin-related protein 3 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-365 Revised 18-Mar-08
Clusterin (nuclear form) (mouse) (recombinant) (His)
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SYNONYMS TRPM-2 (nuclear form) (mouse) (recombinant) (His)
Apolipoprotein J (nuclear form) (mouse) (recombinant) (His)
APO-J (nuclear form) (mouse) (recombinant) (His)
CLI (nuclear form) (mouse) (recombinant) (His)
CLU (nuclear form) (mouse) (recombinant) (His)
SGP-2 (nuclear form) (mouse) (recombinant) (His)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Clusterin / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-365-C050   50 µg 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q549A5: Clusterin (mouse) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Inhibition of post-ischemic brain injury by clusterin overexpression: P. Wehrli, et al.; Nat. Med. 7, 977 (2001) Abstract
Clusterin/apolipoprotein J in human aging and cancer: I.P. Trougakos and E.S. Gonos; Int. J. Biochem. Cell Biol. 34, 1430 (2002) Abstract
Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer: B. Shannan, et al.; Cell Death Differ. 13, 12 (2006) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-368 Revised 04-Apr-07
ANGPTL7 (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 7 (human) (recombinant)
Cornea-derived Transcript 6 Protein (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-368-C010   10 µg 295.00 USD Add To Cart
ALX-201-368-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Human ANGPTL7 (angiopoietin-like protein 7) (aa 1-346) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:   
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
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General Information
Human ANGPTL7 is produced as a secreted glycoprotein with a molecular mass of 45kDa in SDS-PAGE analysis. Human mRNA is expressed in neural tissues, keratoconus cornea, trabecular meshwork, melanotic melanoma and uterus endometrial cancer, while mouse Angptl7 mRNA is expressed in four-cell embryos, synovial fibroblasts, thymus, uterus and testis. ANGPTL7 reduces tumor growth and aberrant blood vessel formation by inducing massive fibrosis in a mouse xenograft model [1]. It was reported that addition of ANGPTL7 results in a further increase in HSC activities. This suggests that ANGPTL7 may activate signal transduction pathways that cannot be activated by SCF, TPO, IGF-2 or FGF-1 [2]. Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signalling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine [3].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link O43827: Angiopoietin-related protein 7 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
[1] The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea: R. Peek, et al.; J. Biol. Chem. 277, 686 (2002) Abstract; Full Text
[2] Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells: C.C. Zhang, et al.; Nat. Med. 12, 240 (2006) Abstract
[3] Comparative integromics on Angiopoietin family members: Y. Katoh and M. Katoh; Int. J. Mol. Med. 17, 1145 (2006) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-373 Revised 18-Mar-08
ANGPTL4 (Coiled-coil Domain) (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 4 (Coiled-coil Domain) (human) (recombinant)
FIAF (Coiled-coil Domain) (human) (recombinant)
Fasting-induced Adipose Factor (Coiled-coil Domain) (human) (recombinant)
HFARP (Coiled-coil Domain) (human) (recombinant)
Hepatic Fibrinogen/Angiopoietin-related Protein (Coiled-coil Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-373-C010   10 µg 295.00 USD Add To Cart
ALX-201-373-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and coiled-coil domain of human ANGPTL4 (angiopoietin-like protein 4) (aa 1-161) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9BY76: Angiopoietin-related protein 4 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-377 Revised 06-May-08
Progranulin (human) (recombinant)
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SYNONYMS Proepithelin (human) (recombinant)
PEPI (human) (recombinant)
PC Cell-derived Growth Factor (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY Progranulin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-377-C010   10 µg 180.00 USD Add To Cart
ALX-201-377-C050   50 µg 480.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Signal peptide and mature human progranulin (aa 1-593) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION: 1mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Images
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General Information
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis. The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P28799: Granulins (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Granulins, a novel class of peptide from leukocytes: A. Bateman, et al.; BBRC 173, 1161 (1990) Abstract
Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis: Z. He & A. Bateman; J. Mol. Med. 81, 600 (2003) Abstract
Progranulin is a mediator of the wound response: Z. He, et al.; Nat. Med. 9, 225 (2003) Abstract
Progranulin in frontotemporal lobar degeneration and neuroinflammation: Z. Ahmed, et al.; J. Neuroinflammation 4, 7 (2007), (Review) Abstract; Full Text
Progranulin: normal function and role in neurodegeneration: J.L. Eriksen & I.R. Mackenzie; J. Neurochem. 104, 287 (2008), (Review) Abstract
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Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Inflammation Other Products
 
 
ALX-201-378 Revised 18-Mar-08
ANGPTL3 (Coiled-coil Domain) (human) (recombinant)
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SYNONYMS Angiopoietin-like Protein 3 (Coiled-coil Domain) (human) (recombinant)
Angiopoietin-5 (Coiled-coil Domain) (human) (recombinant)
ANG-5 (Coiled-coil Domain) (human) (recombinant)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Angiopoietin-like Proteins [ANGPTLs] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-378-C010   10 µg 295.00 USD Add To Cart
ALX-201-378-C050   50 µg 795.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in HEK 293 cells. Coiled-coil domain of human ANGPTL3 (angiopoietin-like protein 3) (aa 1-222) is fused at the C-terminus to a FLAG®-tag.
CONCENTRATION:  
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in PBS.
ENDOTOXIN CONTENT: <0.1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Product Images
Please click on thumbnails to enlarge.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9Y5C1: Angiopoietin-related protein 3 (human) [Precursor]

FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-201-379 Revised 18-Mar-08
ANGPTL4 (Fibrinogen-like Domain) (human) (recombinant)
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