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Antitumor Reagents
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ALX-380-079 Revised 08-Apr-08
Rebeccamycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-079-C250   250 µg 120.00 USD Add To Cart
ALX-380-079-M001   1 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C27H21Cl2N3O7
MW: 570.4
CAS NUMBER: 93908-02-2
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Protect from light.

Product Description
Antibiotic. Weak topoisomerase I inhibitor structurally similar to staurosporine (Prod. No. ALX-380-014). Does not show any inhibitory activity against protein kinases. Shows significant antitumor properties in vitro (IC50=480nM against mouse B16 melanoma cells and IC50=500nM against P388 leukemia cells).
Product Specific Literature References
Production and biological activity of rebeccamycin, a novel antitumor agent: J.A. Bush, et al.; J. Antibiot. (Tokyo) 40, 668 (1987) Abstract
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group: F. Anizon, et al.; J. Med. Chem. 40, 3456 (1997) Abstract
DNA cleavage by topoisomerase I in the presence of indolocarbazole derivatives of rebeccamycin: C. Bailly, et al.; Biochemistry 36, 3917 (1997) Abstract
Calories from carbohydrates: energetic contribution of the carbohydrate moiety of rebeccamycin to DNA binding and the effect of its orientation on topoisomerase I inhibition: C. Bailly, et al.; Chem. Biol. 6, 277 (1999) Abstract
Further Categories Containing This Product:
Antibiotics - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors)
 
 
ALX-380-136 Revised 20-Nov-08 New product
Reductiomycin
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SYNONYMS AM-6201
S 551II
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-136-M001   1 mg 90.00 USD Add To Cart
ALX-380-136-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C14H15NO6
MW: 293.3
CAS NUMBER: 68748-55-0
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98%
APPEARANCE: Light yellow solid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description
Antibiotic. Shows antibacterial, antifungal, antiviral and antitumor activity.
Product Specific Literature References
Reductiomycin, a new antibiotic. I. Taxonomy, fermentation, isolation, characterization and biological activities: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 649 (1981) Abstract
Reductiomycin, a new antibiotic. II. Structural elucidation by spectroscopic studies: K. Shimizu & G. Tamura; J. Antibiot. (Tokyo) 34, 654 (1981) Abstract
Structure of antitumor alkaloid AM-6201: Y. Konda, et al.; J. Antibiot. (Tokyo) 34, 1222 (1981) Abstract
The alkaloid AM-6201 from Streptomyces xanthochromogenus: M. Onda, et al.; Chem. Pharm. Bull. 30, 1210 (1982)
Studies on the biosynthesis of the antibiotic reductiomycin in Streptomyces xanthochromogenus: H. Cho, et al.; JACS 115, 12296 (1993) Abstract
Iminonitroso Diels-Alder reactions for efficient derivatization and functionalization of complex diene-containing natural products: F. Li, et al.; Org. Lett. 9, 2923 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal • Antibiotics - Antiviral / Anti-HIV • Alkaloids
 
 
ALX-270-125 Revised 25-Apr-08
Resveratrol
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SYNONYMS trans-3,4’,5-Trihydroxystilbene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-125-M050   50 mg 36.00 USD Add To Cart
ALX-270-125-M100   100 mg 50.00 USD Add To Cart
ALX-270-125-M250   250 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C14H12O3
MW: 228.2
CAS NUMBER: 501-36-0
MERCK INDEX: 14: 8158
SOURCE/HOST: Isolated from Polygonum cuspidatum.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: ~65mg/ml soluble in DMSO, 100% ethanol or dimethyl formamide; slightly soluble in PBS, pH 7.2 (~100 µg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Shows cancer chemopreventive activity. Specific inhibitor of cyclooxygenase-1 (COX-1). Inhibits the hydroperoxidase activity of COX-1. Antioxidant. Potent activator of human deacetylase SIRT1. Protects against 4-hydroxynonenal (4-HNE) induced oxidative stress and apoptosis.
Product Specific Literature References
Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta: C.K. Chen, et al.; Gen. Pharmacol. 27, 363 (1996) Abstract
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997) Abstract
Cancer chemopreventive activity of resveratrol: M. Jang & J.M. Pezzuto; Drugs Exp. Clin. Res. 25, 65 (1999) Abstract
Capillary electrophoresis determination, synthesis, and stability of resveratrol and related 3-O-beta-D-glucopyranosides: V. Brandolini, et al.; J. Agric. Food Chem. 50, 7407 (2002) Abstract
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan: K.T. Howitz, et al.; Nature 425, 191 (2003) Abstract
Resveratrol protects against 4-HNE induced oxidative stress and apoptosis in Swiss 3T3 fibroblasts: O. Kutuk, et al.; Biofactors 20, 1 (2004) Abstract
Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats: A.R. Martin, et al.; Biochem. Pharmacol. 67, 1399 (2004) Abstract
Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells: E. Sexton, et al.; Mol. Cancer 5, 45 (2006) Abstract
Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008) Abstract
Related Products
Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Stilbenoids • Sirtuins / Related Products • COX Inhibitors
 
 
ALX-380-118 Revised 13-Mar-07
Reticulol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
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ALX-380-118-C250   250 µg 140.00 USD Add To Cart
ALX-380-118-M001   1 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C11H10O5
MW: 222.2
CAS NUMBER: 26246-41-3
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Inhibitor of cyclic adenosine 3’,5’-monophosphate phosphodiesterase and topoisomerase I (Topo I). Antitumor agent.
Product Specific Literature References
Reticulol, a new metabolic isocoumarin: L.A. Mitscher, et al.; Experientia 20, 258 (1964) Abstract
Isocoumarins from streptomyces mobaraensis: M.A.W. Eaton and D.W. Hutchinson; Tetrahedron Lett. 12, 1337 (1971)
Reticulol, an inhibitor of cyclic adenosine 3’, 5’-monophosphate phosphodiesterase: Y. Furutani, et al.; J. Antibiot. 28, 558 (1975) Abstract
Reticulol, an inhibitor of cyclic nucleotide phosphodiesterases: Y. Furutani, et al.; Agric. Biol. Chem. 41, 989 (1977)
Biosynthetic studies of reticulol, an isocoumarin, by 13C-NMR spectroscopy: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1581 (1977)
Inhibition of cyclic nucleotide phosphodiesterases by reticulol: Y. Furutani, et al.; Agric. Biol. Chem. 41, 1587 (1977)
Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma: D.S. Lim, et al.; Chemotherapy 49, 146 (2003) Abstract
Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma: D.S. Lim, et al.; Chemotherapy 49, 257 (2003) Abstract
An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol) : A. Saeed and S. Ehsan; Chem. Heterocyc. Comp. 41, 1381 (2005)
Further Categories Containing This Product:
Antibiotics - Other Signal Transduction Pathway Modulators • Phosphodiesterases / Related Products • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics
 
 
ALX-430-151 Revised 22-Jul-08
RITA
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SYNONYMS Reactivation of p53 and Induction of Tumor Cell Apoptosis
2,5-bis(5-Hydroxymethyl-2-thienyl)furan
NSC652287
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY p53 Other Products
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ALX-430-151-M001   1 mg 75.00 USD Add To Cart
ALX-430-151-M005   5 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C14H12O3S2
MW: 292.4
CAS NUMBER: 213261-59-7
PURITY: ≥98%
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Soluble in 100% ethanol (1mg/ml), DMSO (20mg/ml), dimethyl formamide (30mg/ml); 0.5mg/ml soluble in a 1:1 solution of dimethyl formamide: PBS (pH 7.2) (dilute the dimethyl formamide solution with PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least two years after receipt when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.

Product Description
Inhibitor of p53/HDM2 interaction. Activator of p53 function in tumors. Potently inhibits the growth of a variety of  cancer cell lines in the submicromolar range. It has been suggested that RITA selectively targets cells expressing p53 by other mechanisms than direct binding to the N-terminal domain of p53 [4].
Product Specific Literature References
[1] DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells: W. Nieves-Neira, et al.; Mol. Pharmacol. 56, 478 (1999) Abstract; Full Text
[2] Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism: M.I. Rivera, et al.; Biochem. Pharmacol. 57, 1283 (1999) Abstract
[3] Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors: N. Issaeva, et al.; Nat. Med. 10, 1321 (2004) Abstract
[4] NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro: M. Krajewski, et al.; Nat. Med. 11, 1135 (2005) Abstract
Further Categories Containing This Product:
Antitumor Agents (Apoptosis Inducers)
 
 
ALX-350-121 Revised 14-Mar-08
Rocaglamide
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SYNONYMS Rocaglamide A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - NF-kB Pathway Inhibitors
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ALX-350-121-C100   100 µg 220.00 USD Add To Cart
Product Specification
FORMULA: C29H31NO7
MW: 505.6
CAS NUMBER: 84573-16-0
SOURCE/HOST: Isolated from Aglaia sp.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white sticky solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Immunosuppressant. Potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. In contrast to the immunosuppressant cyclosporin A (Prod. No. ALX-380-002), rocaglamide does not inhibit calcineurin phosphatase activity. Induces apoptosis.
Product Specific Literature References
X-ray crystal structure of rocaglamide, a novel antileukemic 1H-cyclopenta-(b)-benzofuran from Aglaia elliptofolia: M.L. King, et al.; J. C. S. Chem. Commun. 20, 1150 (1982)
Cyclopenta[b]benzofurans from Aglaia species with pronounced antifungal activity against rice blast fungus (Pyricularia grisea): D. Engelmeier, et al.; J. Agric. Food Chem. 48, 1400 (2000)
Insecticidal rocaglamide derivatives from Aglaia spectabilis (Meliaceae): C. Schneider, et al.; Phytochemistry 54, 731 (2000)
New insecticidal rocaglamide derivatives and related compounds from Aglaia oligophylla: M. Dreyer, et al.; J. Nat. Prod. 64, 415 (2001)
Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada: Chaidir, et al.; J. Nat. Prod. 64, 1216 (2001) Abstract
Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells: B. Baumann, et al.; J. Biol. Chem. 277, 44791 (2002) Abstract; Full Text
Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells: P. Proksch, et al.; J. Immunol. 174, 7075 (2005) Abstract; Full Text
Potential of cyclopenta[b]benzofurans from Aglaia species in cancer chemotherapy: S. Kim, et al.; Anticancer Agents Med. Chem. 6, 319 (2006)
Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata: P. Chumkaew, et al.; Chem. Pharm. Bull. 54, 1344 (2006)
The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities: J.Y. Zhu, et al.; Int. J. Cancer 121, 1839 (2007) Abstract
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Further Categories Containing This Product:
TNF-alpha & TNF Receptors Other Products • Nuclear Factor of Activated T Cells [NF-AT] • Other Natural Products - DNA Regulation / Transcription • Natural Products - Immunomodulators • Natural Products - Chemopreventive Agents • Natural Products - Apoptosis Inducers & Inhibitors • NF-kB Pathway Inhibitors
 
 
ALX-350-343 Revised 14-Nov-07
Roquefortine E
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-350-343-M001   1 mg 195.00 USD Add To Cart
Product Specification
FORMULA: C27H31N5O2
MW: 457.6
CAS NUMBER: 871982-52-4
SOURCE/HOST: Isolated from Gymnoascus reesii MST-FP1700.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Analog of roquefortine C (Prod. No. ALX-350-342). Selective, albeit weakly active antitumor agent.
Product Specific Literature References
Roquefortine E, a diketopiperazine from an Australian isolate of Gymnoascus reessii: B. Clark, et al.; J. Nat. Prod. 68, 1661 (2005) Abstract
Further Categories Containing This Product:
Alkaloids
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
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SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985) Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992) Abstract
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998) Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003) Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003) Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004) Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004) Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006) Abstract
Further Categories Containing This Product:
T Cell Regulation Other Products • Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products - Anti-inflammatory Agents • Polyphenols Other Products • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents
 
 
ALX-380-120 Revised 08-Apr-08
Rubiginone D2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-120-M001   1 mg 100.00 USD Add To Cart
ALX-380-120-M005   5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C20H16O6
MW: 352.3
SOURCE/HOST: Isolated from Streptomyces sp. (strain Gö N1/5).
PURITY: ≥98% (HPLC)